Results 81 to 90 of about 3,724 (177)
Molecular Plant Pathology, Volume 27, Issue 2, February 2026.Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Dhirendra Niroula +3 more
wiley +1 more source
Frontiers in Microbiology, 2018 Pseudomonas aeruginosa causes many biofilm infections, and the rugose small-colony variants (RSCVs) of this bacterium are important for infection. We found here that inactivation of PA2444, which we determined to be a serine hydroxymethyltransferase ...
Mingming Pu +4 more
doaj +1 more source
Protein Target Highlights in CASP16: Insights From the Structure Providers
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander +34 more
wiley +1 more source
Synthesis of Triazole-Linked Analogues of c-di-GMP and Their Interactions with Diguanylate Cyclase [PDF]
Journal of Medicinal Chemistry, 2015 Cyclic di-GMP (c-di-GMP) is a widespread second messenger that plays a key role in bacterial biofilm formation. The compound's ability to assume multiple conformations allows it to interact with a diverse set of target macromolecules. Here, we analyzed the binding mode of c-di-GMP to the allosteric inhibitory site (I-site) of diguanylate cyclases (DGCs)
FERNICOLA, SILVIA +11 more
openaire +4 more sources
BioMed Research International, Volume 2026, Issue 1, 2026.This review explores the role of Pseudomonas aeruginosa biofilms in cystic fibrosis (CF) pathogenesis. Biofilms, the main bacterial lifestyle in CF lungs, are key in therapy failure, immune evasion, and chronic infection persistence. This review examines biofilm structure, emphasizing extracellular polymeric substances (Psl, Pel, alginate, eDNA) and ...
Luis Ángel Núñez-García +4 more
wiley +1 more source
, 2022 Electroactive bacteria have a wide range of applications, including electricity production, bioremediation, and the sensing of toxic compounds. Bacterial biofilm formation is often mediated by the second messenger cyclic guanosine monophosphate (c-di-GMP)
Francesca Formicola +6 more
core +1 more source
Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes.
PLoS Pathogens, 2014 We characterized key components and major targets of the c-di-GMP signaling pathways in the foodborne pathogen Listeria monocytogenes, identified a new c-di-GMP-inducible exopolysaccharide responsible for motility inhibition, cell aggregation, and ...
Li-Hong Chen +7 more
doaj +1 more source
The Diverse Roles of the Histone‐Like Nucleoid Structuring (H‐NS) Protein in Vibrio parahaemolyticus
Genetics Research , Volume 2026, Issue 1, 2026.The histone‐like nucleoid structuring (H‐NS) protein is a global transcriptional regulator critical for bacterial genome organization and gene expression. In Vibrio parahaemolyticus, H‐NS represses virulence factors such as thermostable direct hemolysin (TDH), type III secretion systems (T3SS1/T3SS2), and type VI secretion systems (T6SS1/T6SS2).
Hao Tang, Yiquan Zhang, Richa Sharma
wiley +1 more source
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.Leptospira interrogans serovar Hardjo and Leptospira borgpetersenii serovar Hardjo are major bovine‐ and ovine‐adapted pathogens that differ markedly in genome content. To investigate early events during host exposure, we compared the survival of both species using an ovine peritoneal dialysis membrane chamber (DMC) model, which exposes leptospires to ...
Klaudia Dubniewicz +8 more
wiley +1 more source
MicrobiologyOpen, Volume 14, Issue 6, December 2025.Numerous studies have reported biofilm formation impairment in Pseudomonas aeruginosa clinical isolates, however, the genetic basis of this phenomenon remains largely unexplored. In this study, we aimed to identify associations between impaired‐biofilm formation and loss‐of‐function mutations in biofilm regulatory and effector genes.
Andrei V. Vvedenskii +5 more
wiley +1 more source