Results 81 to 90 of about 35,352 (121)

Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates

npj Biofilms and Microbiomes
Cyclic diguanylate (c-di-GMP) is a central biofilm regulator in Pseudomonas aeruginosa, where increased intracellular levels promote biofilm formation and antibiotic tolerance.
Yu-Ming Cai, Feng Hong, Amber De Craemer, Jacob George Malone, Aurélie Crabbé, Tom Coenye   +5 more
doaj   +1 more source

A GGDEF and EAL domain-containing protein in Pseudomonas syringae pv. actinidiae regulates virulence via its diguanylate cyclase activity

Phytopathology Research
Kiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), poses a severe threat to the global kiwifruit industry, highlighting the urgent need to elucidate its pathogenic mechanisms. Cyclic diguanylate monophosphate (c-di-GMP)
Yudi Wang, Mingming Yang, Jinfang Zhou, Xianwei Xie, Jiabing Ma, Yao Wang, Xihui Shen, Lili Huang   +7 more
doaj   +1 more source

Identification of two different chemosensory pathways in representatives of the genus Halomonas

BMC Genomics, 2018
Background Species of the genus Halomonas are salt-tolerant organisms that have a versatile metabolism and can degrade a variety of xenobiotic compounds, utilizing them as their sole carbon source.
Ana Florencia Gasperotti, María Victoria Revuelta, Claudia Alicia Studdert, María Karina Herrera Seitz   +3 more
doaj   +1 more source

BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation

mBio, 2017
The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria.
Ricardo N. Moreira, Clémentine Dressaire, Susana Barahona, Lisete Galego, Volkhard Kaever, Urs Jenal, Cecília M. Arraiano   +6 more
doaj   +1 more source

Identification of an interaction between diguanylate cyclase CdgB and a putative interacting partner (PIP) in Streptomyces

Streptomyces is a group of filamentous bacteria, best known to produce diverse clinically important antibiotics. This group has a complex life cycle regulated by 3’-5’-cyclic diguanylic acid (c-diGMP).
Prada Mora, Juanita
core   +1 more source

An investigation of the response of a model class IIIA Adenyly Cyclase to carbon dioxide [PDF]

, 2009
Adenylyl cyclase catalyses the conversion of adenosine triphosphate into 3’,5'-cyclic adenosine monophosphate and pyrophosphate. Adenylyl cyclases are grouped into six distinct Classes based on amino acid sequence similarity.
Holliday, Phillip
core  

Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio

Nature Communications, 2019
The initiation of prey invasion by the predatory bacterium Bdellovibrio bacteriovorus is governed by the activity of the diguanlylate cyclase DgcB. Here the authors show that the stimulus regulating DgcB activity is a phosphopeptide derived from DgcB ...
Richard W. Meek, Ian T. Cadby, Patrick J. Moynihan, Andrew L. Lovering   +3 more
doaj   +1 more source

Contribution of Physical Interactions to Signaling Specificity between a Diguanylate Cyclase and Its Effector

mBio, 2015
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger that controls multiple cellular processes. c-di-GMP networks have up to dozens of diguanylate cyclases (DGCs) that synthesize c-di-GMP along with many c-di-GMP-responsive target proteins that ...
Kurt M. Dahlstrom, Krista M. Giglio, Alan J. Collins, Holger Sondermann, George A. O’Toole   +4 more
doaj   +1 more source

Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin [PDF]

, 2010
Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional
Mohammed, Hesham Hamada Taha
core   +1 more source

A diguanylate cyclase regulates motility and biofilm formation in Bordetella bronchiseptica mediated by a GGDEF-EAL protein [PDF]

, 2019
Bordetella bronchiseptica is a bacterium that causes respiratory infections in a variety of mammalian hosts. We have already described c-di-GMP role in motility and biofilm formation. We previously showed that over expressing BdcA (Bordetella diguanylate
Zacca, F., Sisti, Federico, Fernández, Julieta, Gutiérrez, M. P., Belhart, K.   +4 more
core