Results 91 to 100 of about 40,793 (179)

The MarR Family Transcriptional Regulator EmrR Negatively Regulates the Type III Secretion System (T3SS) and Positively Modulates Pathogenicity in Dickeya oryzae

Molecular Plant Pathology, Volume 27, Issue 4, April 2026.
This study revealed that the transcriptional regulator EmrR in Dickeya oryzae modulates virulence by regulating hrpL expression and c‐di‐GMP levels. It affects motility, biofilm formation, cellulase production and pathogenicity. EMSA and footprinting confirmed EmrR binds directly to the promoter of its target operon.
Mingfa Lv, Wenqi Huang, Ziwei Meng, Xiaojing Fan, Peng Li, Zeling Xu, Shaohua Chen, Xiaoyuan Chen, Jianuan Zhou, Lianhui Zhang, Yingying Cheng, Tao Zhuo, Ming Hu   +12 more
wiley   +1 more source

A diguanylate cyclase regulates motility and biofilm formation in Bordetella bronchiseptica mediated by a GGDEF-EAL protein [PDF]

, 2019
Bordetella bronchiseptica is a bacterium that causes respiratory infections in a variety of mammalian hosts. We have already described c-di-GMP role in motility and biofilm formation. We previously showed that over expressing BdcA (Bordetella diguanylate
Zacca, F., Sisti, Federico, Fernández, Julieta, Gutiérrez, M. P., Belhart, K.   +4 more
core  

Expanded Functional Characterization and Optimization of Protein Expression in Treponema denticola Shuttle Plasmids

Molecular Oral Microbiology, Volume 41, Issue 2, Page 69-84, April 2026.
We report optimization of the Treponema denticola shuttle plasmid system by minimizing its size and by characterizing an array of promoter‐gene constructs for genetic complementation, including the first use in Treponema of a Tet‐inducible system for controlled expression of potentially toxic genes.
M. Paula Goetting‐Minesky, Valentina Godovikova, Prakaimuk Saraithong, Alexander H. Rickard, Brigette R. Crawley, Sara M. Agolli, Reagan L. Boyce, Trishna L. Appaji, J. Christopher Fenno   +8 more
wiley   +1 more source

Function, localization and regulation of the Pseudomonas aeruginosa diguanylate cyclase response regulator WspR [PDF]

, 2013
Thesis (Ph.D.)--University of Washington, 2013WspR is a hybrid response regulator-diguanylate cyclase that is phosphorylated by the Wsp signal transduction complex in response to growth of Pseudomonas aeruginosa on surfaces. Active WspR produces c-di-GMP,
Huangyutitham, Varisa
core  

ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.

PLoS Pathogens, 2014
The transcription factor AmrZ regulates genes important for P. aeruginosa virulence, including type IV pili, extracellular polysaccharides, and the flagellum; however, the global effect of AmrZ on gene expression remains unknown, and therefore, AmrZ may ...
Christopher J Jones, David Newsom, Benjamin Kelly, Yasuhiko Irie, Laura K Jennings, Binjie Xu, Dominique H Limoli, Joe J Harrison, Matthew R Parsek, Peter White, Daniel J Wozniak   +10 more
doaj   +1 more source

Bacterial Microbiome Composition and Functional Potentials Across Digestive Regions of Wild New Zealand Abalone (Haliotis iris)

New Zealand Journal of Marine and Freshwater Research, Volume 60, Issue 1, March 2026.
Abalone are valuable commercial marine gastropods, supporting both aquaculture and fishery markets. An important ecological aspect of their survival and physiological performance in a given habitat is a complex and balanced symbiotic relationship with microbes in their digestive system.
Jinchen Guo, Andrea C. Alfaro, Leonie Venter, Donnabella C. Lacap‐Bugler   +3 more
wiley   +1 more source

Identification of an interaction between diguanylate cyclase CdgB and a putative interacting partner (PIP) in Streptomyces

Streptomyces is a group of filamentous bacteria, best known to produce diverse clinically important antibiotics. This group has a complex life cycle regulated by 3’-5’-cyclic diguanylic acid (c-diGMP).
Prada Mora, Juanita
core   +1 more source

Analysis of CdgC as the major diguanylate cyclase in S. venezuelae

, 2021
The proliferation of Gram-positive soil bacteria Streptomyces is temporally and genetically coordinated with a complex developmental life cycle, including three main stages of differentiation: vegetative hyphal growth, formation of aerial mycelium and sporulation.
openaire   +1 more source

Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates

npj Biofilms and Microbiomes
Cyclic diguanylate (c-di-GMP) is a central biofilm regulator in Pseudomonas aeruginosa, where increased intracellular levels promote biofilm formation and antibiotic tolerance.
Yu-Ming Cai, Feng Hong, Amber De Craemer, Jacob George Malone, Aurélie Crabbé, Tom Coenye   +5 more
doaj   +1 more source

A GGDEF and EAL domain-containing protein in Pseudomonas syringae pv. actinidiae regulates virulence via its diguanylate cyclase activity

Phytopathology Research
Kiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), poses a severe threat to the global kiwifruit industry, highlighting the urgent need to elucidate its pathogenic mechanisms. Cyclic diguanylate monophosphate (c-di-GMP)
Yudi Wang, Mingming Yang, Jinfang Zhou, Xianwei Xie, Jiabing Ma, Yao Wang, Xihui Shen, Lili Huang   +7 more
doaj   +1 more source