Results 91 to 100 of about 5,655 (194)

An evolutionary optimization of a rhodopsin-based phototrophic metabolism in Escherichia coli

Microbial Cell Factories, 2017
Background The expression of the Gloeobacter rhodopsin (GR) in a chemotrophic Escherichia coli enables the light-driven phototrophic energy generation. Adaptive laboratory evolution has been used for acquiring desired phenotype of microbial cells and for
Hyun Aaron Kim, Hyun Ju Kim, Jihoon Park, Ah Reum Choi, Kyoo Heo, Haeyoung Jeong, Kwang-Hwan Jung, Yeong-Jae Seok, Pil Kim, Sang Jun Lee   +9 more
doaj   +1 more source

The Diguanylate Cyclase SadC Is a Central Player in Gac/Rsm-Mediated Biofilm Formation in Pseudomonas aeruginosa

, 2014
Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen and a threat for immune-compromised and Cystic Fibrosis patients. It is responsible for acute and chronic infections and can switch between these lifestyles upon taking an informed ...
Filloux, A, Hui, K, Jaeger, T, Jenal, U, Moscoso, JA, Valentini, M   +5 more
core   +2 more sources

The thermosensory diguanylate cyclase (tdcA)

, 2016
Biofilm production in Pseudomonas aeruginosa is regulated by the intracellular secondary messenger cyclic diguanylate (c-di-GMP). C-di-GMP is produced by diguanylate cyclases (DGCs) and degraded by phosphodiesterases (PDEs). C-di-GMP controls motility, biofilm formation and virulence factor production in many bacteria.
openaire   +2 more sources

Pseudomonas aeruginosa Biofilms in Cystic Fibrosis: Interactions, Methods, and Therapeutic Strategies

BioMed Research International, Volume 2026, Issue 1, 2026.
This review explores the role of Pseudomonas aeruginosa biofilms in cystic fibrosis (CF) pathogenesis. Biofilms, the main bacterial lifestyle in CF lungs, are key in therapy failure, immune evasion, and chronic infection persistence. This review examines biofilm structure, emphasizing extracellular polymeric substances (Psl, Pel, alginate, eDNA) and ...
Luis Ángel Núñez-García, Carlos Córdova-Fletes, María Carmen Barboza-Cerda, Elvira Garza-González, Baisakhi Banerjee   +4 more
wiley   +1 more source

The Diverse Roles of the Histone‐Like Nucleoid Structuring (H‐NS) Protein in Vibrio parahaemolyticus

Genetics Research , Volume 2026, Issue 1, 2026.
The histone‐like nucleoid structuring (H‐NS) protein is a global transcriptional regulator critical for bacterial genome organization and gene expression. In Vibrio parahaemolyticus, H‐NS represses virulence factors such as thermostable direct hemolysin (TDH), type III secretion systems (T3SS1/T3SS2), and type VI secretion systems (T6SS1/T6SS2).
Hao Tang, Yiquan Zhang, Richa Sharma
wiley   +1 more source

High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity [PDF]

, 2016
The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs).
Aragon, Barahona, Baraquet, Berendsen, Boller, Burdette, Cao, Chinchilla, Clarke, Dangl, Dasgupta, Dong, Engl, Felix, Forsyth, Gal, Gomez-Gomez, Goymer, Guttman, Hann, Heese, Hengge, Hickman, Hickman, Jackson, Kazmierczak, Kovach, Kulasakara, Kunze, Lacombe, Lee, Li, Loon, Loper, Loper, Lugtenberg, Macho, Malone, Marino, Matilla, Miya, Newell, Nuhse, Peart, Pel, Perez-Mendoza, Plotnikova, Robleto, Rossez, Roux, Schulze, Schwessinger, Segonzac, Spangler, Starkey, Sun, Torres, Van Wees, Wang, Willmann, Winsor, Xin, Yan, Zamioudis, Zeng, Zhang, Zipfel, Zipfel, Zipfel   +68 more
core   +1 more source

Serine Hydroxymethyltransferase ShrA (PA2444) Controls Rugose Small-Colony Variant Formation in Pseudomonas aeruginosa

Frontiers in Microbiology, 2018
Pseudomonas aeruginosa causes many biofilm infections, and the rugose small-colony variants (RSCVs) of this bacterium are important for infection. We found here that inactivation of PA2444, which we determined to be a serine hydroxymethyltransferase ...
Mingming Pu, Lili Sheng, Sooyeon Song, Ting Gong, Thomas K. Wood   +4 more
doaj   +1 more source

Intact and mutated Shigella diguanylate cyclases increase c-di-GMP

Journal of Biological Chemistry
The intracellular human pathogen Shigella invades the colonic epithelium to cause disease. Prior to invasion, this bacterium navigates through different environments within the human body, including the stomach and the small intestine. To adapt to changing environments, Shigella uses the bacterial second messenger cyclic di-GMP (c di-GMP) signaling ...
Ruchi Ojha, Stefanie Krug, Prentiss Jones, Benjamin J. Koestler   +3 more
openaire   +2 more sources

Divergent Fates of Hardjo Leptospires: Early Transcriptomic Response of Leptospira interrogans in an Ovine Dialysis Membrane Chamber Model

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Leptospira interrogans serovar Hardjo and Leptospira borgpetersenii serovar Hardjo are major bovine‐ and ovine‐adapted pathogens that differ markedly in genome content. To investigate early events during host exposure, we compared the survival of both species using an ovine peritoneal dialysis membrane chamber (DMC) model, which exposes leptospires to ...
Klaudia Dubniewicz, Laura Pardyak, Patrycja Walczak, Agnieszka Pietsch-Fulbiszewska, Artur Gurgul, Igor Jasielczuk, Tomasz Szmatoła, Zbigniew J. Arent, Yong-guo Cao   +8 more
wiley   +1 more source

Genetic Determinants Associated With the Biofilm Formation Impairment in Pseudomonas aeruginosa Clinical Isolates

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Numerous studies have reported biofilm formation impairment in Pseudomonas aeruginosa clinical isolates, however, the genetic basis of this phenomenon remains largely unexplored. In this study, we aimed to identify associations between impaired‐biofilm formation and loss‐of‐function mutations in biofilm regulatory and effector genes.
Andrei V. Vvedenskii, Alina S. Ivkina, Dmitry N. Konanov, Tatiana A. Savinova, Ludmila S. Fedorova, Elena N. Ilina   +5 more
wiley   +1 more source