Results 71 to 80 of about 35,352 (121)

Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes.

PLoS Pathogens, 2014
We characterized key components and major targets of the c-di-GMP signaling pathways in the foodborne pathogen Listeria monocytogenes, identified a new c-di-GMP-inducible exopolysaccharide responsible for motility inhibition, cell aggregation, and ...
Li-Hong Chen, Volkan K Köseoğlu, Zehra T Güvener, Tanya Myers-Morales, Joseph M Reed, Sarah E F D'Orazio, Kurt W Miller, Mark Gomelsky   +7 more
doaj   +1 more source

Structural basis of activity and allosteric control of diguanylate cyclase [PDF]

, 2004
Recent discoveries suggest that a novel second messenger, bis-(3'--
Samoray, D., Jenal, U., Schirmer, T., Amiot, N. C., Giese, B., Chan, C., Paul, R.   +6 more
core   +1 more source

Bacterial Microbiome Composition and Functional Potentials Across Digestive Regions of Wild New Zealand Abalone (Haliotis iris)

New Zealand Journal of Marine and Freshwater Research, Volume 60, Issue 1, March 2026.
Abalone are valuable commercial marine gastropods, supporting both aquaculture and fishery markets. An important ecological aspect of their survival and physiological performance in a given habitat is a complex and balanced symbiotic relationship with microbes in their digestive system.
Jinchen Guo, Andrea C. Alfaro, Leonie Venter, Donnabella C. Lacap‐Bugler   +3 more
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Structural biology of bacterial response regulator proteins and their complexes with cognate ligands [PDF]

, 2009
Two bacterial response regulator systems were studied in this thesis. NMR spectroscopy and X-ray crystallography were used to determine the structures of both domains of the antibiotic sensor TipAL, as well as of the c-di-GMP receptor PA4608, in ...
Allan, Martin Georg
core   +1 more source

Distinct strategies of diguanylate cyclase domain proteins on inhibition of virulence and interbacterial competition by agrobacteria

mBio
Diguanylate cyclases (DGCs) synthesize bis-(3′,5′)-cyclic diguanylic acid (c-di-GMP), a critical bacterial second messenger that coordinates diverse biological processes.
Xuan Lai, Manda Yu, Chiu-Ping Cheng, Erh-Min Lai   +3 more
doaj   +1 more source

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di‐GMP‐Specific EAL Phosphodiesterases

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
The A526V substitution, previously not recognised to affect the functionality of the EAL domain, downregulates the apparent catalytic activity of the PAS‐GGDEF‐EAL ZMO1055 phosphodiesterase and other GGDEF‐EAL proteins. Substitution of A526, which is conserved among homologues, with amino acids with longer aliphatic side chains than valine, reverts to ...
Lian‐Ying Cao, Xue Zhang, Feng‐wu Bai, Ute Römling   +3 more
wiley   +1 more source

ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.

PLoS Pathogens, 2014
The transcription factor AmrZ regulates genes important for P. aeruginosa virulence, including type IV pili, extracellular polysaccharides, and the flagellum; however, the global effect of AmrZ on gene expression remains unknown, and therefore, AmrZ may ...
Christopher J Jones, David Newsom, Benjamin Kelly, Yasuhiko Irie, Laura K Jennings, Binjie Xu, Dominique H Limoli, Joe J Harrison, Matthew R Parsek, Peter White, Daniel J Wozniak   +10 more
doaj   +1 more source

Heterologous complementation analysis in E. coli of the diguanylate cyclase activity from single GGDEF domains encoded by At. caldus genes.

, 2015
The ability of GGDEF-domain proteins to synthesize c-di-GMP and to induce a Red phenotype on a Congo red agar plate (A) by the E. coli MG1655 wild type strain (1), AM70 diguanylate cyclase null-mutant strain (2) and E.
Douglas E. Rawlings (481576), Lina Ruiz (692628), Matías Castro (4865401), Shelly M. Deane (692627), Nicolas Guiliani (692629)   +4 more
core   +1 more source

Folding of the transcription factor Brinker and interactions of the bacterial second messenger c-di-GMP studied by NMR [PDF]

, 2013
Nuclear magnetic resonance (NMR) spectroscopy is a technique, which allows the non-invasive investigation of structures, dynamics and interactions of biomolecules.
Gentner, Martin
core   +1 more source