Results 71 to 80 of about 3,724 (177)

Characterization of Mycobacterium leprae diguanylate cyclases

, 2016
Mycobacterium leprae is the causative agent of leprosy, which is still a major health problem in several developing countries. Management of leprosy has been challenging because of the long incubation period of the disease and the development of a spectrum of clinical manifestations.
Rotcheewaphan, Suwatchareeporn, author, Belisle, John T., advisor, Borlee, Brad R., committee member, Brennan, Patrick J., committee member, Jackson, Mary, committee member, Prenni, Jessica E., committee member   +5 more
openaire   +1 more source

Expanded Functional Characterization and Optimization of Protein Expression in Treponema denticola Shuttle Plasmids

Molecular Oral Microbiology, Volume 41, Issue 2, Page 69-84, April 2026.
We report optimization of the Treponema denticola shuttle plasmid system by minimizing its size and by characterizing an array of promoter‐gene constructs for genetic complementation, including the first use in Treponema of a Tet‐inducible system for controlled expression of potentially toxic genes.
M. Paula Goetting‐Minesky, Valentina Godovikova, Prakaimuk Saraithong, Alexander H. Rickard, Brigette R. Crawley, Sara M. Agolli, Reagan L. Boyce, Trishna L. Appaji, J. Christopher Fenno   +8 more
wiley   +1 more source

A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus.

PLoS Genetics, 2016
Generally, the second messenger bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) regulates the switch between motile and sessile lifestyles in bacteria. Here, we show that c-di-GMP is an essential regulator of multicellular development in the social bacterium ...
Dorota Skotnicka, Gregory T Smaldone, Tobias Petters, Eleftheria Trampari, Jennifer Liang, Volkhard Kaever, Jacob G Malone, Mitchell Singer, Lotte Søgaard-Andersen   +8 more
doaj   +1 more source

Regulation of Protein Secretion Systems Mediated by Cyclic Diguanylate in Plant-Interacting Bacteria

Frontiers in Microbiology, 2019
The ubiquitous second messenger cyclic diguanylate (c-di-GMP) is involved in the regulation of different processes in bacteria. In phytopathogens, intracellular fluctuations in the concentration of this molecule contribute to the lifestyle switching from
Francisco Javier López-Baena, Jose María Vinardell, Carlos Medina   +2 more
doaj   +1 more source

Population Genomics of Microbial Biostalactites: Non-recombinogenic Genome Islands and Microdiversification by Transposons

Frontiers in Microbiology, 2022
Intrapopulation genetic variability in prokaryotes is receiving increasing attention thanks to improving sequencing methods; however, the ability to distinguish intrapopulation variability from species clusters or initial stages of gene flow barrier ...
Kateřina Burkartová, Jiří Dresler, Jakub Rídl, Jakub Rídl, Lukáš Falteisek   +4 more
doaj   +1 more source

Bacterial Microbiome Composition and Functional Potentials Across Digestive Regions of Wild New Zealand Abalone (Haliotis iris)

New Zealand Journal of Marine and Freshwater Research, Volume 60, Issue 1, March 2026.
Abalone are valuable commercial marine gastropods, supporting both aquaculture and fishery markets. An important ecological aspect of their survival and physiological performance in a given habitat is a complex and balanced symbiotic relationship with microbes in their digestive system.
Jinchen Guo, Andrea C. Alfaro, Leonie Venter, Donnabella C. Lacap‐Bugler   +3 more
wiley   +1 more source

An evolutionary optimization of a rhodopsin-based phototrophic metabolism in Escherichia coli

Microbial Cell Factories, 2017
Background The expression of the Gloeobacter rhodopsin (GR) in a chemotrophic Escherichia coli enables the light-driven phototrophic energy generation. Adaptive laboratory evolution has been used for acquiring desired phenotype of microbial cells and for
Hyun Aaron Kim, Hyun Ju Kim, Jihoon Park, Ah Reum Choi, Kyoo Heo, Haeyoung Jeong, Kwang-Hwan Jung, Yeong-Jae Seok, Pil Kim, Sang Jun Lee   +9 more
doaj   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Diguanylate Cyclases Control Magnesium-Dependent Motility ofVibrio fischeri [PDF]

Journal of Bacteriology, 2006
ABSTRACTFlagellar biogenesis and hence motility ofVibrio fischeridepends upon the presence of magnesium. In the absence of magnesium, cells contain few or no flagella and are poorly motile or nonmotile. To dissect the mechanism by which this regulation occurs, we screened transposon insertion mutants for those that could migrate through soft agar ...
Therese M, O'Shea, Adam H, Klein, Kati, Geszvain, Alan J, Wolfe, Karen L, Visick   +4 more
openaire   +2 more sources

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di‐GMP‐Specific EAL Phosphodiesterases

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
The A526V substitution, previously not recognised to affect the functionality of the EAL domain, downregulates the apparent catalytic activity of the PAS‐GGDEF‐EAL ZMO1055 phosphodiesterase and other GGDEF‐EAL proteins. Substitution of A526, which is conserved among homologues, with amino acids with longer aliphatic side chains than valine, reverts to ...
Lian‐Ying Cao, Xue Zhang, Feng‐wu Bai, Ute Römling   +3 more
wiley   +1 more source