Molecular logics in dual sensor regulation of diguanylate cyclase activity-Phosphorylation OR blue-light activation. [PDF]
Protein SciAbstract Bacterial cells use multiple environmental cues to regulate levels of the second messenger cyclic dimeric GMP. This compound influences key lifestyle decisions such as motility, biofilm formation, or virulence. Although many diguanylate cyclases (DGCs) combined with various sensory domains have been studied previously, how distinct inputs are ...
Fuchs M, Winkler A.
europepmc +2 more sources
Diguanylate Cyclase and Phosphodiesterase Interact to Maintain the Specificity of Cyclic Di-GMP Signaling in the Regulation of Antibiotic Synthesis in Lysobacter Enzymogenes. [PDF]
Applied and Environmental Microbiology, 2022 Fengquan Liu, Guoliang Qian, Gaoge Xu
exaly +2 more sources
Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts
Life, 2021 GGDEF-containing proteins respond to different environmental cues to finely modulate cyclic diguanylate (c-di-GMP) levels in time and space, making the allosteric control a distinctive trait of the corresponding proteins.
Federico Mantoni +10 more
doaj +1 more source
Identification of flgZ as a flagellar gene encoding a PilZ domain protein that regulates swimming motility and biofilm formation in Pseudomonas. [PDF]
PLoS ONE, 2014 Diguanylate cyclase and phosphodiesterase enzymatic activities control c-di-GMP levels modulating planktonic versus sessile lifestyle behavior in bacteria.
Francisco Martínez-Granero +8 more
doaj +1 more source
Dynamics-Driven Allosteric Stimulation of Diguanylate Cyclase Activity in a Red Light-Regulated Phytochrome [PDF]
Journal of Biological ChemistryAndreas Winkler +2 more
exaly +2 more sources
GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP
npj Biofilms and Microbiomes, 2022 In bacteria, the monopolar localization of enzymes and protein complexes can result in a bimodal distribution of enzyme activity between the dividing cells and heterogeneity of cellular behaviors.
Tim Rick +12 more
doaj +1 more source
Bacteriophage‐mediated interference of the c‐di‐GMP signalling pathway in Pseudomonas aeruginosa
Microbial Biotechnology, 2021 Summary C‐di‐GMP is a key signalling molecule which impacts bacterial motility and biofilm formation and is formed by the condensation of two GTP molecules by a diguanylate cyclase.
Jeroen De Smet +7 more
doaj +1 more source
Microorganisms, 2023 Expression of rdar (red, dry, and rough) colony morphology-based biofilm formation in Escherichia coli is highly variable. To investigate the molecular mechanisms of semi-constitutive rdar morphotype formation, we compared their cyclic di-GMP turnover ...
Annika Cimdins-Ahne +4 more
doaj +1 more source
Identification of Small-Molecule Modulators of Diguanylate Cyclase by FRET-Based High-Throughput Screening [PDF]
ChemBioChem, 2019 Matthias Christen +2 more
exaly +2 more sources
π-Helix controls activity of oxygen-sensing diguanylate cyclases [PDF]
Bioscience Reports, 2020 Abstract The ability of organisms to sense and adapt to oxygen levels in their environment leads to changes in cellular phenotypes, including biofilm formation and virulence. Globin coupled sensors (GCSs) are a family of heme proteins that regulate diverse functions in response to O2 levels, including modulating synthesis of cyclic ...
Johnnie A. Walker +3 more
openaire +2 more sources