Results 31 to 40 of about 35,352 (121)

Screening for Diguanylate Cyclase (DGC) Inhibitors Mitigating Bacterial Biofilm Formation

Frontiers in Chemistry, 2020
The majority of bacteria in the natural environment organize themselves into communal biofilms. Biofilm formation benefits bacteria conferring resistance to harmful molecules (e.g., antibiotics, disinfectants, and host immune factors) and coordinating ...
Kyu Hong Cho, R. Grant Tryon, Jeong-Ho Kim   +2 more
doaj   +1 more source

Structure and signaling mechanism of a zinc-sensory diguanylate cyclase [PDF]

, 2013
Diguanylate cyclases synthesize the second messenger c-di-GMP, which in turn governs a plethora of physiological processes in bacteria. Although most diguanylate cyclases harbor sensory domains, their input signals are largely unknown.
Zähringer, Franziska, Schirmer, Tilman, Boehm, Alex, Lacanna, Egidio, Jenal, Urs   +4 more
core   +1 more source

Specific Control of Pseudomonas aeruginosa Surface-Associated Behaviors by Two c-di-GMP Diguanylate Cyclases

mBio, 2010
The signaling nucleotide cyclic diguanylate (c-di-GMP) regulates the transition between motile and sessile growth in a wide range of bacteria. Understanding how microbes control c-di-GMP metabolism to activate specific pathways is complicated by the ...
Judith H. Merritt, Dae-Gon Ha, Kimberly N. Cowles, Wenyun Lu, Diana K. Morales, Joshua Rabinowitz, Zemer Gitai, George A. O’Toole   +7 more
doaj   +1 more source

Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes

Frontiers in Microbiology, 2022
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in the expression
Kira Eilers, Joey Kuok Hoong Yam, Richard Morton, Adeline Mei Hui Yong, Jaime Brizuela, Jaime Brizuela, Corina Hadjicharalambous, Corina Hadjicharalambous, Xianghui Liu, Michael Givskov, Michael Givskov, Scott A. Rice, Scott A. Rice, Alain Filloux, Alain Filloux   +14 more
doaj   +1 more source

Bacterial cyclic diguanylate signaling networks sense temperature

, 2021
Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, we identify a thermosensory diguanylate cyclase (TdcA) that modulates temperature-dependent motility, biofilm development ...
Singh, Manu, Nicolas Fournier, Julie Groizeleau, Justin L. MacCallum, Joe Jonathan Harrison, Jennings, Laura K., Good, Nathan M., Ian A. Lewis, Weerayuth Kittichotirat, Singletary, Larissa A., Ann Karen Cornelia Brassinga, Ayush Kumar, MacCallum, Justin L., Lou, Yuefei, Maria Silvina Stietz, Rich, Jacquelyn D., Bryan G. Yipp, Stietz, Maria Silvina, Bumgarner, Roger E., Hynes, Michael F., Trevor E. Randall, Fournier, Nicolas, Kumar, Ayush, Elise Granton, Groves, Ryan A., Yipp, Bryan G., Randall, Trevor E., Katherine Leblanc, Fanny Liu, Kittichotirat, Weerayuth, Boo Shan Tseng, Parsek, Matthew R., Jacquelyn D. Rich, Roger E. Bumgarner, Fiona S. L. Brinkman, Brinkman, Fiona S.L., Tseng, Boo Shan, Yuefei Lou, Laura K. Jennings, Emily Au, Winsor, Geoffrey L., Matthew R. Parsek, Au, Emily, Almblad, Henrik, Nathan M. Good, Larissa A. Singletary, Groizeleau, Julie, Henrik Almblad, Michael F. Hynes, Manu Singh, Harrison, Joe Jonathan, Liu, Fanny, Brassinga, Ann Karen Cornelia, Leblanc, Katherine, Lewis, Ian A., Geoffrey L. Winsor, Granton, Elise, Tara M. L. Winstone, Winstone, Tara M.L., Ryan A. Groves   +59 more
core   +1 more source

Cyclic‐di‐GMP signalling and biofilm‐related properties of the Shiga toxin‐producing 2011 German outbreak Escherichia coli O104:H4

EMBO Molecular Medicine, 2014
In 2011, nearly 4,000 people in Germany were infected by Shiga toxin (Stx)‐producing Escherichia coli O104:H4 with > 22% of patients developing haemolytic uraemic syndrome (HUS).
Anja M Richter, Tatyana L Povolotsky, Lothar H Wieler, Regine Hengge   +3 more
doaj   +1 more source

Characterization of a Diguanylate Cyclase VAGM001033 of Vibrio alginolyticus and Protective Efficacy as a Live Attenuated Vaccine Candidate in Pearl Gentian Grouper

Frontiers in Marine Science, 2022
Vibrio alginolyticus (V. alginolyticus) is one of the important epizootic pathogens in marine animals. VAGM001033 belongs to a diguanylate cyclase, responsible for the synthesis of dimeric guanosine monophosphate (c-di-GMP), a ubiquitous second messenger
Huiming Tan, Fan Da, Guixiang Lin, Xiaoju Wan, Jichang Jian, Jichang Jian, Shuanghu Cai, Shuanghu Cai   +7 more
doaj   +1 more source

Cooperative substrate binding by a diguanylate cyclase

, 2021
XAC0610, from Xanthomonas citri subsp. citri, is a large multi-domain protein containing one GAF (cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA) domain, four PAS (Per-Arnt-Sim) domains and one GGDEF domain.
Oliveira, Maycon C., Andrade, Maxuel O., Teixeira, Raphael D., Pinheiro, Glaucia M. S., Ramos, Carlos H. I., Farah, Chuck S.   +5 more
core   +2 more sources

Diguanylate Cyclases in Vibrio cholerae: Essential Regulators of Lifestyle Switching

Frontiers in Cellular and Infection Microbiology, 2020
Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components—both proteinaceous and non-proteinaceous, the key to the ...
Sumit Biswas, Om Prakash Chouhan, Divya Bandekar   +2 more
doaj   +1 more source

A horizontally transferred bacterial gene for pantothenic acid biosynthesis regulates diapause and reproduction in the spider mite Amphitetranychus viennensis

Insect Science, EarlyView.
A bacterial‐derived AvPBL gene encoding a pantothenate‐β‐alanine ligase was identified in Amphitetranychus viennensis. RNAi silencing of AvPBL reduced pantothenic acid production, impairing reproduction and diapause induction, while pantothenic acid supplementation rescued these phenotypes.
Meibin Liu, Yifei Wang, Yikang Ren, Fan Yang, Meifeng Ren, Qin Yu, Xuguo Zhou, Zezhong Yang, Jing Yang   +8 more
wiley   +1 more source