Results 11 to 20 of about 3,724 (177)

A Symphony of Cyclases: Specificity in Diguanylate Cyclase Signaling [PDF]

Annual Review of Microbiology, 2017
Cyclic diguanylate (c-di-GMP) is a near universal signaling molecule produced by diguanylate cyclases that can direct a variety of bacterial behaviors. A major area of research over the last several years has been aimed at understanding how a cell with dozens of diguanylate cyclases can deploy a given subset of them to produce a desired phenotypic ...
George A O´Toole
exaly   +6 more sources

Phosphorylation-independent regulation of the diguanylate cyclase WspR.

PLoS Biology, 2008
Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second messenger.
Nabanita De, Michelle Pirruccello, Petya Violinova Krasteva, Narae Bae, Rahul Veera Raghavan, Holger Sondermann   +5 more
doaj   +5 more sources

Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate

Biotechnology Reports, 2015
Cyclic-diGMP is a bacterial messenger that regulates many physiological processes, including many attributed to pathogenicity. Bacteria synthesize cyclic-diGMP from GTP using diguanylate cyclases; its hydrolysis is catalyzed by phosphodiesterases.
Natasha M. Nesbitt, Dhruv P. Arora, Roger A. Johnson, Elizabeth M. Boon   +3 more
doaj   +4 more sources

Evaluation and characterization of the predicted diguanylate cyclase‐encoding genes in Pseudomonas aeruginosa [PDF]

MicrobiologyOpen, 2020
Opportunistic pathogen Pseudomonas aeruginosa can cause acute and chronic infections in humans. It is notorious for its resistance to antibiotics due to the formation of biofilms.
Pramod Bhasme, Qing Wei, Anming Xu, Syed Tatheer Alam Naqvi, Di Wang, Luyan Z. Ma   +5 more
doaj   +5 more sources

Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio [PDF]

Nature Communications, 2019
The initiation of prey invasion by the predatory bacterium Bdellovibrio bacteriovorus is governed by the activity of the diguanlylate cyclase DgcB. Here the authors show that the stimulus regulating DgcB activity is a phosphopeptide derived from DgcB ...
Richard W. Meek, Ian T. Cadby, Patrick J. Moynihan, Andrew L. Lovering   +3 more
doaj   +7 more sources

Structure and Signaling Mechanism of a Zinc-Sensory Diguanylate Cyclase [PDF]

Structure, 2013
Diguanylate cyclases synthesize the second messenger c-di-GMP, which in turn governs a plethora of physiological processes in bacteria. Although most diguanylate cyclases harbor sensory domains, their input signals are largely unknown. Here, we demonstrate that diguanylate cyclase DgcZ (YdeH) from Escherichia coli is regulated allosterically by zinc ...
Zähringer, Franziska, Lacanna, Egidio, Jenal, Urs, Schirmer, Tilman, Boehm, Alex   +4 more
core   +8 more sources

Diguanylate Cyclase Activation: It Takes Two [PDF]

Structure, 2007
Characterization of an activated diguanylate cyclase reported in this issue of Structure by Wassmann et al. (2007) reveals how phosphorylation promotes dimerization necessary for synthesis of the second messenger c-di-GMP, establishes the catalytic mechanism, and identifies a widely conserved mode of product inhibition.
Stock, Ann M.
openaire   +2 more sources

Activation of the Diguanylate Cyclase PleD by Phosphorylation-mediated Dimerization [PDF]

Journal of Biological Chemistry, 2007
Diguanylate cyclases (DGCs) are key enzymes of second messenger signaling in bacteria. Their activity is responsible for the condensation of two GTP molecules into the signaling compound cyclic di-GMP. Despite their importance and abundance in bacteria, catalytic and regulatory mechanisms of this class of enzymes are poorly understood.
Paul, Ralf, Abel, Sören, Wassmann, Paul, Beck, Andreas, Heerklotz, Heiko, Jenal, Urs   +5 more
openaire   +5 more sources

The importance of conserved amino acids in heme-based globin-coupled diguanylate cyclases.

PLoS ONE, 2017
Globin-coupled diguanylate cyclases contain globin, middle, and diguanylate cyclase domains that sense O2 to synthesize c-di-GMP and regulate bacterial motility, biofilm formation, and virulence.
Xuehua Wan, Jennifer A Saito, James S Newhouse, Shaobin Hou, Maqsudul Alam   +4 more
doaj   +2 more sources

The thermosensory diguanylate cyclase (tdcA)

, 2016
Biofilm production in Pseudomonas aeruginosa is regulated by the intracellular secondary messenger cyclic diguanylate (c-di-GMP). C-di-GMP is produced by diguanylate cyclases (DGCs) and degraded by phosphodiesterases (PDEs). C-di-GMP controls motility, biofilm formation and virulence factor production in many bacteria.
Randall, Trevor Ethan
openaire   +3 more sources