Phosphorylation-independent regulation of the diguanylate cyclase WspR.
PLoS Biology, 2008 Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second messenger.
Nabanita De +5 more
doaj +6 more sources
Evaluation and characterization of the predicted diguanylate cyclase‐encoding genes in Pseudomonas aeruginosa [PDF]
MicrobiologyOpen, 2020 Opportunistic pathogen Pseudomonas aeruginosa can cause acute and chronic infections in humans. It is notorious for its resistance to antibiotics due to the formation of biofilms.
Pramod Bhasme +5 more
doaj +5 more sources
A Symphony of Cyclases: Specificity in Diguanylate Cyclase Signaling. [PDF]
Annu Rev Microbiol, 2017 Cyclic diguanylate (c-di-GMP) is a near universal signaling molecule produced by diguanylate cyclases that can direct a variety of bacterial behaviors. A major area of research over the last several years has been aimed at understanding how a cell with dozens of diguanylate cyclases can deploy a given subset of them to produce a desired phenotypic ...
Dahlstrom KM, O'Toole GA.
europepmc +6 more sources
Biotechnology Reports, 2015 Cyclic-diGMP is a bacterial messenger that regulates many physiological processes, including many attributed to pathogenicity. Bacteria synthesize cyclic-diGMP from GTP using diguanylate cyclases; its hydrolysis is catalyzed by phosphodiesterases.
Natasha M. Nesbitt +3 more
doaj +3 more sources
Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa [PDF]
eLife, 2021 Cyclic-di-guanosine monophosphate (c-di-GMP) is an important effector associated with acute-chronic infection transition in Pseudomonas aeruginosa. Previously, we reported a signaling network SiaABCD, which regulates biofilm formation by modulating c-di ...
Gukui Chen +10 more
doaj +2 more sources
Distinct strategies of diguanylate cyclase domain proteins on inhibition of virulence and interbacterial competition by agrobacteria [PDF]
mBioDiguanylate cyclases (DGCs) synthesize bis-(3′,5′)-cyclic diguanylic acid (c-di-GMP), a critical bacterial second messenger that coordinates diverse biological processes.
Xuan Lai +3 more
doaj +2 more sources
A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus. [PDF]
PLoS Genetics, 2016 Generally, the second messenger bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) regulates the switch between motile and sessile lifestyles in bacteria. Here, we show that c-di-GMP is an essential regulator of multicellular development in the social bacterium ...
Dorota Skotnicka +8 more
doaj +4 more sources
Diguanylate Cyclases in Vibrio cholerae: Essential Regulators of Lifestyle Switching [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components—both proteinaceous and non-proteinaceous, the key to the ...
Sumit Biswas +2 more
doaj +3 more sources
Activation of the Diguanylate Cyclase PleD by Phosphorylation-mediated Dimerization [PDF]
Journal of Biological Chemistry, 2007 Diguanylate cyclases (DGCs) are key enzymes of second messenger signaling in bacteria. Their activity is responsible for the condensation of two GTP molecules into the signaling compound cyclic di-GMP. Despite their importance and abundance in bacteria, catalytic and regulatory mechanisms of this class of enzymes are poorly understood.
Paul, Ralf +5 more
openaire +5 more sources
Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio [PDF]
Nature Communications, 2019 The initiation of prey invasion by the predatory bacterium Bdellovibrio bacteriovorus is governed by the activity of the diguanlylate cyclase DgcB. Here the authors show that the stimulus regulating DgcB activity is a phosphopeptide derived from DgcB ...
Richard W. Meek +3 more
doaj +2 more sources