Results 11 to 20 of about 40,793 (179)
A Symphony of Cyclases: Specificity in Diguanylate Cyclase Signaling [PDF]
Annual Review of Microbiology, 2017 Cyclic diguanylate (c-di-GMP) is a near universal signaling molecule produced by diguanylate cyclases that can direct a variety of bacterial behaviors. A major area of research over the last several years has been aimed at understanding how a cell with ...
George A O'Toole
exaly +6 more sources
Phosphorylation-independent regulation of the diguanylate cyclase WspR.
PLoS Biology, 2008 Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second messenger.
Nabanita De +5 more
doaj +5 more sources
Biotechnology Reports, 2015 Cyclic-diGMP is a bacterial messenger that regulates many physiological processes, including many attributed to pathogenicity. Bacteria synthesize cyclic-diGMP from GTP using diguanylate cyclases; its hydrolysis is catalyzed by phosphodiesterases.
Natasha M. Nesbitt +3 more
doaj +4 more sources
Evaluation and characterization of the predicted diguanylate cyclase‐encoding genes in Pseudomonas aeruginosa [PDF]
MicrobiologyOpen, 2020 Opportunistic pathogen Pseudomonas aeruginosa can cause acute and chronic infections in humans. It is notorious for its resistance to antibiotics due to the formation of biofilms.
Pramod Bhasme +5 more
doaj +5 more sources
Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio [PDF]
Nature Communications, 2019 The initiation of prey invasion by the predatory bacterium Bdellovibrio bacteriovorus is governed by the activity of the diguanlylate cyclase DgcB. Here the authors show that the stimulus regulating DgcB activity is a phosphopeptide derived from DgcB ...
Richard W. Meek +3 more
doaj +7 more sources
Structure and signaling mechanism of a zinc-sensory diguanylate cyclase [PDF]
Structure, 2013 Diguanylate cyclases synthesize the second messenger c-di-GMP, which in turn governs a plethora of physiological processes in bacteria. Although most diguanylate cyclases harbor sensory domains, their input signals are largely unknown.
Zähringer, Franziska +14 more
core +8 more sources
Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization [PDF]
Journal of Biological Chemistry, 2007 Diguanylate cyclases (DGCs) are key enzymes of second messenger signaling in bacteria. Their activity is responsible for the condensation of two GTP molecules into the signaling compound cyclic di-GMP.
Abel, Sören +17 more
core +5 more sources
Cooperative substrate binding by a diguanylate cyclase
Journal of Molecular Biology, 2021 XAC0610, from Xanthomonas citri subsp. citri, is a large multi-domain protein containing one GAF (cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA) domain, four PAS (Per-Arnt-Sim) domains and one GGDEF domain.
Oliveira, Maycon C. +5 more
core +4 more sources
The thermosensory diguanylate cyclase (tdcA)
, 2016 Biofilm production in Pseudomonas aeruginosa is regulated by the intracellular secondary messenger cyclic diguanylate (c-di-GMP). C-di-GMP is produced by diguanylate cyclases (DGCs) and degraded by phosphodiesterases (PDEs).
Randall, Trevor Ethan
core +3 more sources
Structural basis of activity and allosteric control of diguanylate cyclase [PDF]
Proceedings of the National Academy of Sciences, 2004 Recent discoveries suggest that a novel second messenger, bis-(3'--
Samoray, D. +20 more
core +7 more sources