Thermoregulation of Biofilm Formation in Burkholderia pseudomallei Is Disrupted by Mutation of a Putative Diguanylate Cyclase. [PDF]
J Bacteriol, 2017 Plumley BA +9 more
europepmc +1 more source
Genetic dissection of Escherichia coli's master diguanylate cyclase DgcE: Role of the N-terminal MASE1 domain and direct signal input from a GTPase partner system. [PDF]
PLoS Genet, 2019 Pfiffer V +3 more
europepmc +1 more source
Correction: The Diguanylate Cyclase HsbD Intersects with the HptB Regulatory Cascade to Control Pseudomonas aeruginosa Biofilm and Motility. [PDF]
PLoS Genet, 2016 Valentini M +4 more
europepmc +1 more source
The diguanylate cyclase GcpA inhibits the production of pectate lyases via the H-NS protein and RsmB regulatory RNA in Dickeya dadantii. [PDF]
Mol Plant Pathol, 2018 Yuan X +7 more
europepmc +1 more source
Matrix Polysaccharides and SiaD Diguanylate Cyclase Alter Community Structure and Competitiveness of Pseudomonas aeruginosa during Dual-Species Biofilm Development with Staphylococcus aureus. [PDF]
mBio, 2018 Chew SC +9 more
europepmc +1 more source
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Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase
Analytical Biochemistry, 2009The cyclic dinucleotide c-di-GMP is a widespread bacterial messenger molecule with potential application as a therapeutic agent for treating bacterial infection. Current enzymatic synthesis of c-di-GMP using mesophilic diguanylate cyclase (DGC) proteins suffers from low production yield due to protein instability and strong product inhibition.
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Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase
Bioorganic & Medicinal Chemistry, 2010Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of
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Shigella flexneri Diguanylate Cyclases Regulate Virulence
Journal of Bacteriology, 2021The intracellular human pathogen Shigella causes dysentery, resulting in as many as one million deaths per year. Currently, there is no approved vaccine for the prevention of shigellosis, and the incidence of antimicrobial resistance among Shigella species is on the rise.
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Cooperative Substrate Binding by a Diguanylate Cyclase
Journal of Molecular Biology, 2015XAC0610, from Xanthomonas citri subsp. citri, is a large multi-domain protein containing one GAF (cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA) domain, four PAS (Per-Arnt-Sim) domains and one GGDEF domain. This protein has a demonstrable in vivo and in vitro diguanylate cyclase (DGC) activity that leads to the production of cyclic di ...
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Structural analysis of an oxygen-regulated diguanylate cyclase
Acta Crystallographica Section D Biological Crystallography, 2015Cyclic di-GMP is a bacterial second messenger that is involved in switching between motile and sessile lifestyles. Given the medical importance of biofilm formation, there has been increasing interest in understanding the synthesis and degradation of cyclic di-GMPs and their regulation in various bacterial pathogens.
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