Screening for Diguanylate Cyclase (DGC) Inhibitors Mitigating Bacterial Biofilm Formation [PDF]
Frontiers in Chemistry, 2020 The majority of bacteria in the natural environment organize themselves into communal biofilms. Biofilm formation benefits bacteria conferring resistance to harmful molecules (e.g., antibiotics, disinfectants, and host immune factors) and coordinating ...
Kyu Hong Cho +2 more
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Biotechnology Reports, 2015 Cyclic-diGMP is a bacterial messenger that regulates many physiological processes, including many attributed to pathogenicity. Bacteria synthesize cyclic-diGMP from GTP using diguanylate cyclases; its hydrolysis is catalyzed by phosphodiesterases.
Natasha M. Nesbitt +3 more
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Evaluation and characterization of the predicted diguanylate cyclase‐encoding genes in Pseudomonas aeruginosa [PDF]
MicrobiologyOpen, 2020 Opportunistic pathogen Pseudomonas aeruginosa can cause acute and chronic infections in humans. It is notorious for its resistance to antibiotics due to the formation of biofilms.
Pramod Bhasme +5 more
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Design of novel hybrid secondary metabolite targets to diguanylate cyclase of Acinetobacter baumannii. [PDF]
FEMS Microbes, 2021 AbstractBiofilm formation in bacteria is a resistance determinant and is positively regulated by cyclic diguanylate signaling. This signaling is a near universal signaling, and c-di-GMP produced by diguanylate cyclase (DGC) in this signaling is involved in different bacterial behaviors.
Tiwari M, Joshi R, Tiwari V.
europepmc +5 more sources
Flagellar Stators Activate a Diguanylate Cyclase To Inhibit Flagellar Stators [PDF]
J Bacteriol, 2019 The bacterial secondary metabolite cyclic di-GMP is a widespread, cytoplasmic signal that promotes a physiological transition in which motility is inhibited and biofilm formation is activated. A paper published in this issue (A. E. Baker, S. S. Webster, A. Diepold, S. L. Kuchma, E.
Kearns DB.
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Distinct chromophore-protein environments enable asymmetric activation of a bacteriophytochrome-activated diguanylate cyclase. [PDF]
J Biol Chem, 2020 Sensing of red and far-red light by bacteriophytochromes involves intricate interactions between their bilin chromophore and the protein environment. The light-triggered rearrangements of the cofactor configuration and eventually the protein conformation enable bacteriophytochromes to interact with various protein effector domains for biological ...
Buhrke D +5 more
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Phosphorylation-independent regulation of the diguanylate cyclase WspR.
PLoS Biology, 2008 Environmental signals that trigger bacterial pathogenesis and biofilm formation are mediated by changes in the level of cyclic dimeric guanosine monophosphate (c-di-GMP), a unique eubacterial second messenger.
Nabanita De +5 more
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A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus. [PDF]
PLoS Genetics, 2016 Generally, the second messenger bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) regulates the switch between motile and sessile lifestyles in bacteria. Here, we show that c-di-GMP is an essential regulator of multicellular development in the social bacterium ...
Dorota Skotnicka +8 more
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Diguanylate Cyclases in Vibrio cholerae: Essential Regulators of Lifestyle Switching [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components—both proteinaceous and non-proteinaceous, the key to the ...
Sumit Biswas +2 more
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Regulation of Protein Secretion Systems Mediated by Cyclic Diguanylate in Plant-Interacting Bacteria [PDF]
Frontiers in Microbiology, 2019 The ubiquitous second messenger cyclic diguanylate (c-di-GMP) is involved in the regulation of different processes in bacteria. In phytopathogens, intracellular fluctuations in the concentration of this molecule contribute to the lifestyle switching from
Francisco Javier López-Baena +2 more
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