Bacterial rotary export ATPases are allosterically regulated by the nucleotide second messenger cyclic-di-GMP [PDF]
, 2015 The widespread second messenger molecule cyclic di-GMP (cdG) regulates the transition from motile and virulent lifestyles to sessile, biofilm-forming ones in a wide range of bacteria. Many pathogenic and commensal bacterial-host interactions are known to
Abel +89 more
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A novel c-di-GMP signal system regulates biofilm formation in Pseudomonas aeruginosa
Microbial Cell, 2020 The bacterial second messenger cyclic-di-GMP (c-di-GMP) controls biofilm formation and other phenotypes relevant to pathogenesis. The human pathogen Pseudomonas aeruginosa encodes 17 diguanylate cyclase (DGCs) proteins which are required for c-di-GMP ...
Gukui Chen, Haihua Liang
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Progress in understanding of the molecular basis underlying functional diversification of cyclic di-nucleotide turnover proteins [PDF]
, 2016 Cyclic di-GMP was the first cyclic di-nucleotide second messenger described, presaging the discovery of additional cyclic di-nucleotide messengers in bacteria and eukaryotes.
Dow, J. Maxwell +2 more
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Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain. [PDF]
PLoS ONE, 2013 Pseudomonas aeruginosa is responsible for a plethora of biofilm mediated chronic infections among which cystic fibrosis pneumonia is the most frightening. The long-term survival strategy of P.
Giorgio Giardina +6 more
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A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa [PDF]
, 2018 Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms in natural environments and in host–pathogen interactions.
Cutruzzolà, F. +8 more
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Nucleotide second messengers in bacterial decision making [PDF]
, 2020 Since the initial discovery of bacterial nucleotide second messengers (NSMs), we have made huge progress towards understanding these complex signalling networks. Many NSM networks contain dozens of metabolic enzymes and binding targets, whose activity is
Malone, Jacob, Thompson, Catriona
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Activation of the Diguanylate Cyclase PleD by Phosphorylation-mediated Dimerization [PDF]
Journal of Biological Chemistry, 2007 Diguanylate cyclases (DGCs) are key enzymes of second messenger signaling in bacteria. Their activity is responsible for the condensation of two GTP molecules into the signaling compound cyclic di-GMP. Despite their importance and abundance in bacteria, catalytic and regulatory mechanisms of this class of enzymes are poorly understood.
Paul, Ralf +5 more
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Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of
mBio, 2011 Proteins that metabolize or bind the nucleotide second messenger cyclic diguanylate regulate a wide variety of important processes in bacteria. These processes include motility, biofilm formation, cell division, differentiation, and virulence.
Assaf Levi +3 more
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Cyanobacteriochrome SesA Is a Diguanylate Cyclase That Induces Cell Aggregation in Thermosynechococcus [PDF]
Journal of Biological Chemistry, 2014 Cyanobacteria have unique photoreceptors, cyanobacteriochromes, that show diverse spectral properties to sense near-UV/visible lights. Certain cyanobacteriochromes have been shown to regulate cellular phototaxis or chromatic acclimation of photosynthetic pigments.
Gen Enomoto +5 more
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mBio, 2016 Cell division arrest is a universal checkpoint in response to environmental assaults that generate cellular stress. In bacteria, the cyclic di-GMP (c-di-GMP) signaling network is one of several signal transduction systems that regulate key processes in ...
Hyo Kyung Kim, Rasika M. Harshey
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