Results 71 to 80 of about 5,940 (209)

High levels of cyclic di-GMP in Klebsiella pneumoniae attenuate virulence in the lung [PDF]

, 2018
The bacterial second messenger bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) has been shown to influence the expression of virulence factors in certain pathogenic bacteria, but little is known about its activity in the increasingly antibiotic-resistant ...
Hunstad, David A, Rosen, David A, Twentyman, Joy   +2 more
core   +2 more sources

Cyclic di-GMP: second messenger extraordinaire [PDF]

, 2017
Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di-GMP).
Jenal, Urs, Lori, Christian, Reinders, Alberto   +2 more
core   +1 more source

Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes

Frontiers in Microbiology, 2022
Pseudomonas aeruginosa is a Gram-negative bacterium that is able to survive and adapt in a multitude of niches as well as thrive within many different hosts. This versatility lies within its large genome of ca. 6 Mbp and a tight control in the expression
Kira Eilers, Joey Kuok Hoong Yam, Richard Morton, Adeline Mei Hui Yong, Jaime Brizuela, Jaime Brizuela, Corina Hadjicharalambous, Corina Hadjicharalambous, Xianghui Liu, Michael Givskov, Michael Givskov, Scott A. Rice, Scott A. Rice, Alain Filloux, Alain Filloux   +14 more
doaj   +1 more source

Causes and biophysical consequences of cellulose production by Pseudomonas fluorescens SBW25 at the air-liquid interface

, 2019
Cellulose over-producing wrinkly spreader mutants of Pseudomonas fluorescens SBW25 have been the focus of much investigation, but conditions promoting the production of cellulose in ancestral SBW25, its effects and consequences have escaped in-depth ...
Ardré, M., Dufour, D., Rainey, P.
core   +1 more source

Surface sensing for biofilm formation in Pseudomonas aeruginosa [PDF]

, 2017
YesAggregating and forming biofilms on biotic or abiotic surfaces are ubiquitous bacterial behaviors under various conditions. In clinical settings, persistent presence of biofilms increases the risks of healthcare-associated infections and imposes ...
Alexander, Ali-Ahmad, Alm, Baker, Baraquet, Baraquet, Barken, Belete, Bernier, Bhagirath, Breidenstein, Buensuceso, Caiazza, Chambonnier, Chua, Crouzet, Davies, De, Dötsch, Fata Moradali, Flemming, Fulcher, Galperin, Guilbaud, Gupta, Gupta, Güvener, Hancock, Heacock-Kang, Heiniger, Hengge, Hickman, Hickman, Hook, Hook, Huangyutitham, Irie, Jain, Johnson, Jones, Kanack, Kong, Kuchma, Kuchma, Kuchma, Kulasekara, Lapouge, Lee, Leighton, Li, Liao, Lin Chua, Luo, McCarter, Merighi, Merritt, Merritt, Mesaros, Mikkelsen, Monds, Moradali, Moscoso, Moscoso, Nadal Jimenez, Oglesby, Olsen, Orans, Patell, Percival, Persat, Poole, Rao, Ribbe, Rodesney, Romling, Rosenthal, Russotto, Siryaporn, Smith, Stewart, Su, Tuson, Ueda, Ueda, Vakulskas, Valentini, van Schaik, Wei, Whitchurch, Whitchurch, Winsor, Wolfgang, Wood, Wood, Yu   +94 more
core   +2 more sources

TheTreponema denticolaDgcA protein (TDE0125) is a functional diguanylate cyclase

Pathogens and Disease, 2021
ABSTRACTPeriodontal disease (PD) is a progressive inflammatory condition characterized by degradation of the gingival epithelium, periodontal ligament, and alveolar bone ultimately resulting in tooth loss. Treponema denticola is a keystone periopathogen that contributes to immune dysregulation and direct tissue destruction.
Dhara T Patel, Nathaniel S O'Bier, Edward J A Schuler, Richard T Marconi   +3 more
openaire   +2 more sources

Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases [PDF]

, 2017
The bacterial second messenger cyclic di-3′,5′-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs)
A Deepthi, A Sundriyal, A Tchigvintsev, A Ueda, A Vagin, A Winkler, AD Tischler, AD Tischler, AJ Schmidt, B Huang, BW Holloway, C Chan, C Romier, CD Boyd, CW Phippen, D Balasubramanian, D Bellini, DA D’Argenio, DJ Hosfield, DL Caly, EF Pettersen, F Rao, F Rao, G Kuppuraj, G Minasov, G Winter, G Winter, GL Winsor, GN Murshudov, H Ceri, H Kulasakara, H Zheng, I Ivanov, ID Hay, J Robert-Paganin, JH Merritt, K Syson, K-H Choi, KD Miner, KM Thormann, M Christen, M Valentini, M Vorachit, MD Winn, MVAS Navarro, MY Galperin, N Barraud, O Kirillina, P Aldridge, P Emsley, P Evans, PD Newell, PR Evans, R Donlan, R Paul, R Simm, R Tamayo, RM Keegan, RP Ryan, RP Ryan, RZ Liao, TRM Barends, TT Hoang, U Römling, V Stelitano, VB Chen, W Grzybkowski, W Kabsch, Y Li, Y Qi, Y Wang   +70 more
core   +2 more sources

Diguanylate cyclase DgcP is involved in plant and human Pseudomonas spp. infections

Environmental microbiology, 2015
Peer ...
Aragon, IM, Faure, E, Filloux, A, Gallegos, M-T, Guery, B, Moscoso, JA, Pérez-Mendoza, D, Ramos, C   +7 more
core   +6 more sources

Characterization of a Diguanylate Cyclase VAGM001033 of Vibrio alginolyticus and Protective Efficacy as a Live Attenuated Vaccine Candidate in Pearl Gentian Grouper

Frontiers in Marine Science, 2022
Vibrio alginolyticus (V. alginolyticus) is one of the important epizootic pathogens in marine animals. VAGM001033 belongs to a diguanylate cyclase, responsible for the synthesis of dimeric guanosine monophosphate (c-di-GMP), a ubiquitous second messenger
Huiming Tan, Fan Da, Guixiang Lin, Xiaoju Wan, Jichang Jian, Jichang Jian, Shuanghu Cai, Shuanghu Cai   +7 more
doaj   +1 more source

Specialized and shared functions of diguanylate cyclases and phosphodiesterases inStreptomycesdevelopment [PDF]

Molecular Microbiology, 2020
AbstractLevels of the second messenger bis-3’-5’-cyclic di-guanosinemonophosphate (c-di-GMP) determine whenStreptomycesinitiate sporulation to survive under adverse conditions. c-di-GMP signals are integrated into the genetic differentiation network by the regulator BldD and the sigma factor σWhiG.
Haist, Julian, Neumann, Sara Alina, Al-Bassam, Mahmoud M, Lindenberg, Sandra, Elliot, Marie A, Tschowri, Natalia   +5 more
openaire   +2 more sources