Results 81 to 90 of about 5,940 (209)
Allosteric control of cyclic di-GMP signaling [PDF]
, 2006 Cyclic di-guanosine monophosphate is a bacterial second messenger that has been implicated in biofilm formation, antibiotic resistance, and persistence of pathogenic bacteria in their animal host.
Christen, B. +7 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.Database mining using principal component analysis (PCA)‐based clustering enabled discovery of bacterial enzymes capable of catalyzing stereodivergent cyclopropanation of styrene. Statistical analyses of sequence data further revealed characteristic structural properties of these enzymes, highlighting the potential of the bioinformatics tools for ...
Shunsuke Kato +5 more
wiley +1 more source
Roles of the second messenger cyclic di-GMP in environmental adaptation of Sinorhizobium meliloti [PDF]
, 2017 Bacteria have evolved various systems for the integration of environmental signals to rapidly coordinate cellular pathways and adapt to changes in their environment.
Schäper, Simon
core +1 more source
Molecular Oral Microbiology, EarlyView.We report optimization of the Treponema denticola shuttle plasmid system by minimizing its size and by characterizing an array of promoter‐gene constructs for genetic complementation, including the first use in Treponema of a Tet‐inducible system for controlled expression of potentially toxic genes.
M. Paula Goetting‐Minesky +8 more
wiley +1 more source
Characterization of Mycobacterium leprae diguanylate cyclases
, 2016 Mycobacterium leprae is the causative agent of leprosy, which is still a major health problem in several developing countries. Management of leprosy has been challenging because of the long incubation period of the disease and the development of a spectrum of clinical manifestations.
Rotcheewaphan, Suwatchareeporn, author +5 more
openaire +1 more source
Protein Target Highlights in CASP16: Insights From the Structure Providers
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander +34 more
wiley +1 more source
ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa. [PDF]
PLoS Pathogens, 2014 The transcription factor AmrZ regulates genes important for P. aeruginosa virulence, including type IV pili, extracellular polysaccharides, and the flagellum; however, the global effect of AmrZ on gene expression remains unknown, and therefore, AmrZ may ...
Christopher J Jones +10 more
doaj +1 more source
MicrobiologyOpen, Volume 14, Issue 6, December 2025.Numerous studies have reported biofilm formation impairment in Pseudomonas aeruginosa clinical isolates, however, the genetic basis of this phenomenon remains largely unexplored. In this study, we aimed to identify associations between impaired‐biofilm formation and loss‐of‐function mutations in biofilm regulatory and effector genes.
Andrei V. Vvedenskii +5 more
wiley +1 more source
Environmental Microbiology, Volume 27, Issue 11, November 2025.Antibiotic persister cells in Acinetobacter baumannii: review of the molecular mechanisms involved in this physiology, such as toxin/antitoxin, second messengers, SOS response, PAA or membranes; and elimination strategies such as antibiotics or phages.
Delphine Vergoz +3 more
wiley +1 more source
, 2016 The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates many bacterial behaviors and is of key importance for driving the lifestyle switch between motile loner cells and biofilm formers.
Filloux, A, Valentini, M
core +2 more sources