Results 71 to 80 of about 3,994 (169)

Comparative efficacy of dihydroartemisinin, chloroquine and combination of dihydroartemisinin and chloroquine or mefloquine in mice infected with <i>Plasmodium berghei</i>

, 2006
Comparative efficacy of dihydroartemisinin alone, chloroquine alone, combination of dihydroartemisinin plus mefloquine and combination of dihydroartemisinin plus chloroquine was evaluated in mice.
Aina, OO, OO Aina, PM Emeka, A Akintonwa, Agomo, PU, Akintonwa, A, Emeka, PM, PU Agomo   +7 more
core   +1 more source

Metabolite Profile and Biological Activities of Zanthoxylum nemorale: A Metabolomic and Multivariate Statistical Analysis Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
An integrated LC‐HRMS metabolomics and bioactivity approach reveals the chemical diversity and biological potential of Zanthoxylum nemorale. Extraction solvent and plant organ markedly influence metabolite profiles and bioactivity, with methanolic extracts exhibiting pronounced antioxidant and antibacterial activities, particularly against Gram ...
Victor S. A. de Lira, Floricéa M. Araújo, Rodrigo N. Santos, Lourdes C. Souza‐Neta, Leonardo Zambotti‐Villela, Pio Colepicolo, Lidyanne Y. S. Aona, Paulo R. Ribeiro   +7 more
wiley   +1 more source

Design, Synthesis, and Mechanism of Dihydroartemisinin–Coumarin Hybrids as Potential Anti-Neuroinflammatory Agents

Molecules, 2019
Cancer patients frequently suffer from cancer-related fatigue (CRF), which is a complex syndrome associated with weakness and depressed mood. Neuroinflammation is one of the major inducers of CRF.
Haonan Yu, Zhuang Hou, Xiaoguang Yang, Yanhua Mou, Chun Guo   +4 more
doaj   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma

Frontiers in Pharmacology, 2020
Osteosarcoma cellular iron concentration is higher than that in normal bone cells and other cell types. High levels of cellular iron help catalyze the Fenton reaction to produce reactive oxygen species (ROS), which promotes cancer cell proliferation ...
Ying Shen, Ying Shen, Ying Shen, Bin Zhang, Bin Zhang, Bin Zhang, Yanwei Su, Yanwei Su, Yanwei Su, Shaikh Atik Badshah, Shaikh Atik Badshah, Xiaofei Wang, Xin Li, Xin Li, Xin Li, Yanru Xue, Yanru Xue, Yanru Xue, Li Xie, Li Xie, Zhe Wang, Zhe Wang, Zhouqi Yang, Zhouqi Yang, Ge Zhang, Peng Shang, Peng Shang   +26 more
doaj   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, Volume 7, Issue 5, October 2026.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Effects of dihydroartemisinin on the gut microbiome of mice

Molecular Medicine Reports, 2020
Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin, which has been found to exhibit a broad range of biological activities, excluding antimalarial effects; however its effects on the gut microbiota remain poorly understood. The present study aimed to investigate the effects of DHA on the gut microbiome in mice and to determine its ...
Yanyan Liu, Yanhong Yang, Yuting Lei, Lanxiang Yang, Xueying Zhang, Jian Yuan, Zili Lei   +6 more
openaire   +3 more sources

Human fortilin is a molecular target of dihydroartemisinin [PDF]

FEBS Letters, 2008
Dehydroartemisinin (DHA) is an effective anti‐malaria agent. Fortilin is an anti‐apoptotic molecule overexpressed in many human cancers. Here, we show that DHA binds human fortilin, increases the ubiquitination of fortilin, shortens fortilin's half‐life in a proteasome‐dependent fashion, and reduces cellular levels of fortilin in varieties of cells ...
Fujita, Takayuki, Felix, Kumar, Pinkaew, Decha, Hutadilok-Towatana, Nongporn, Liu, Zhihe, Fujise, Ken   +5 more
openaire   +2 more sources

Iron Homeostasis and Liver Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Iron is an essential micronutrient whose ability to cycle between ferric (Fe3+) and ferrous (Fe2+) states makes it crucial for physiological processes, including oxygen transport, DNA synthesis, and oxidative phosphorylation. However, because both deficiency and excess can cause severe pathology, precise regulation is critical. The liver plays
Peng Yang, Zhitian Shi, Qin Huang, Zhihong Tu, Yue Sun, Lin Wang, Yonglong Wei   +6 more
wiley   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source