Results 71 to 80 of about 11,186 (206)

Choreoathetosis – an unusual adverse effect of dihydroartemisinin-piperaquine: a case report

Journal of Medical Case Reports, 2017
Background Dihydroartemisinin-piperaquine is a combination of dihydroartemisinin and piperaquine which is highly effective in the treatment of uncomplicated falciparum malaria. Its adverse effects are generally tolerable and temporary.
Benjamin Momo Kadia, Christian Morfaw, Armelle Corrine Gounoue Simo   +2 more
doaj   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Design, Synthesis, and Evaluation of New 1,4‐Naphthoquinone‐1,2,3‐triazoles as Antimalarial Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Compound 9g, a 1,4‐naphthoquinone‐1,2,3‐triazole derivative, exhibited potent activity against P. falciparum 3D7 and in silico analysis revealed strong interactions with 1J3 and 1LDG targets, while MD simulations confirmed the stability of the ligand‐3FGO complex.
Lina Rezainia, Mohammad Hosein Sayahi, Eisa Kaveh Vernousfaderani, Seyedeh Sara Mirfazli, Mohammad Hossein Morshedsolouk, Navid Dastyafteh, Mehdi Nateghpour, Leila Farivar, Mina Saeedi, Haleh Hanifian, Mahdi Mohebali, Seyedeh Mana Shafiee, Gholamreza Hassanpour, Mohammad Mahdavi   +13 more
wiley   +1 more source

Lactoferrin and Nanotechnology: New Insights Into Glioblastoma Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Current glioblastoma multiforme (GBM) management primarily relies on surgery, chemotherapy, and radiotherapy; however, therapeutic efficacy remains limited due to tumor invasiveness and restricted drug penetration across the blood–brain barrier. Lactoferrin (LF), an iron‐binding glycoprotein with receptor‐mediated transport capability, has emerged as a
Atena Abed, Javad Amini Mahabadi
wiley   +1 more source

Human fortilin is a molecular target of dihydroartemisinin [PDF]

FEBS Letters, 2008
Dehydroartemisinin (DHA) is an effective anti‐malaria agent. Fortilin is an anti‐apoptotic molecule overexpressed in many human cancers. Here, we show that DHA binds human fortilin, increases the ubiquitination of fortilin, shortens fortilin's half‐life in a proteasome‐dependent fashion, and reduces cellular levels of fortilin in varieties of cells ...
Fujita, Takayuki, Felix, Kumar, Pinkaew, Decha, Hutadilok-Towatana, Nongporn, Liu, Zhihe, Fujise, Ken   +5 more
openaire   +2 more sources

Pharmacokinetic and Pharmacodynamic Characteristics of a new Pediatric Formulation of Artemether-Lumefantrine in African Children with Uncomplicated Plasmodium Falciparum Malaria. [PDF]

, 2011
The pharmacokinetic and pharmacodynamic properties of a new pediatric formulation of artemether-lumefantrine, dispersible tablet, were determined within the context of a multicenter, randomized, parallel-group study.
Lyimo, John, Tekete, Mamadou, Abdulla, Salim, Salim Abdulla, Bassat, Quique, Abdoulaye A. Djimdé, Mandomando, Inacio, Gilbert Lefèvre, Lefèvre, Gilbert, null null, Djimdé, Abdoulaye A, Mamadou Tekete, Borrmann, Steffen, John Lyimo, Quique Bassat, Steffen Borrmann, Inacio Mandomando   +16 more
core   +1 more source

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Resistance to venetoclax has become a critical bottleneck limiting its long‐term clinical benefits. A thorough understanding of the underlying resistance mechanisms and the development of novel strategies to overcome resistance are central to improving survival outcomes in elderly AML patients. Abstract To date, the treatment of acute myeloid leukaemia
Jinlin Zhang, Jile Liu, Mohan Zhao, Xiaoyu Zhang, Linlin Liu, Mengnan Li, Changze Cao, Rui Zhang, Mingfeng Zhao   +8 more
wiley   +1 more source

Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria. [PDF]

, 2007
Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited.
Singhasivanon, P, Price, R N, Peto, L, Mytton, O T, La, Y, Ashley, E A, Ashley, EA, Hae, R, Mytton, OT, Price, RN, White, NJ, White, Nicholas, Nosten, F, White, N J   +13 more
core  

A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia. [PDF]

, 2007
OBJECTIVES: To compare the efficacy and tolerability of dihydroartemisinin-piperaquine (DHA-PQP) with that of a 3-day regimen of mefloquine and artesunate (MAS3) for the treatment of uncomplicated falciparum malaria in Cambodia.
D. Socheat, Van Herp, M, Nong, S, Goubert, L, Ashley, E A, M. Van Herp, S. Nong, E. A. Ashley, Brockman, A., Uong, S, L. Goubert, Goubert, L., Socheat, D, Van Damme, W., W. Van Damme, Chan, S, Van Herp, M., Uong, S., B. Janssens, S. Chan, A. Brockman, Van Damme, W, Socheat, D., Brockman, A, Ashley, E. A., S. Uong, Janssens, B., Janssens, B, Chan, S.   +28 more
core   +1 more source

Efficacy of dihydroartemisinin/piperaquine in patients with noncomplicated Plasmodium falciparum malaria in Yaoundé, Cameroon

, 2021
International audienceBackground: Dihydroartemisinin/piperaquine is increasingly used for the treatment of uncomplicated Plasmodium falciparum malaria in Africa.
Lanot, Thomas, Ayong, Lawrence, Iriart, Xavier, Morlais, Isabelle, Menard, Sandie, Khim, Nimol, Gandia, Peggy, Witkowski, Benoit, Nsango, Sandrine, Abega, Francis, Srun, Sreynet, Mairet-Khedim, Mélissa, Otam, Laure, Berry, Antoine, Roesch, Camille, Ngou, Christelle   +15 more
core   +1 more source