Results 51 to 60 of about 3,994 (169)

Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells

Frontiers in Cellular Neuroscience, 2017
Glioblastoma (GBM) is the most advanced and aggressive form of gliomas. Dihydroartemisinin (DHA) has been shown to exhibit anti-tumor activity in various cancer cells.
Chengbin Qu, Chengbin Qu, Chengbin Qu, Jun Ma, Jun Ma, Jun Ma, Xiaobai Liu, Xiaobai Liu, Xiaobai Liu, Yixue Xue, Yixue Xue, Yixue Xue, Jian Zheng, Jian Zheng, Jian Zheng, Libo Liu, Libo Liu, Libo Liu, Jing Liu, Jing Liu, Jing Liu, Zhen Li, Zhen Li, Zhen Li, Lei Zhang, Lei Zhang, Lei Zhang, Yunhui Liu, Yunhui Liu, Yunhui Liu   +29 more
doaj   +1 more source

Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway

Open Medicine, 2023
Dihydroartemisinin (DHA) has been found to inhibit the expression of von Willebrand factor (VWF), a marker of endothelial cell injury, but its mechanism in cerebral ischemia/reperfusion (I/R) injury remains obscure.
Duan Qi, Wu Junxia
doaj   +1 more source

RETRACTED: Dihydroartemisinin Suppresses the Tumorigenesis and Cycle Progression of Colorectal Cancer by Targeting CDK1/CCNB1/PLK1 Signaling

Frontiers in Oncology, 2021
Dihydroartemisinin (DHA), a well-known antimalarial drug, has been widely investigated for its antitumor effects in multiple malignancies. However, its effects and regulatory mechanisms in colorectal cancer (CRC) are still unproved.
You-Cai Yi, Rui Liang, Xiao-Yu Chen, Hui-Ning Fan, Ming Chen, Jing Zhang, Jin-Shui Zhu   +6 more
doaj   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Dihydroartemisinin as a Sensitizing Agent in Cancer Therapies

OncoTargets and Therapy, 2021
Cancer is one of the major threats to human health. Although humans have struggled with cancer for decades, the efficacy of treatments for most tumors is still very limited. Dihydroartemisinin (DHA) is a derivative of artemisinin, a first-line antimalarial drug originally developed in China.
Qingrong Li, Qiang Ma, Jibing Cheng, Xi Zhou, Wenjie Pu, Xiaowu Zhong, Xiaolan Guo   +6 more
openaire   +4 more sources

Dihydroartemisinin Sensitizes Esophageal Squamous Cell Carcinoma to Cisplatin by Inhibiting Sonic Hedgehog Signaling

Frontiers in Cell and Developmental Biology, 2020
Platinum-based regimens have been routinely used in the clinical treatment of patients with esophageal squamous cell carcinoma (ESCC). However, administration of these drugs is frequently accompanied by drug resistance.
Wei Cui, Tingting Fang, Zhaoheng Duan, Dongfang Xiang, Yanxia Wang, Mengsi Zhang, Fangzheng Zhai, Xiang Cui, Lang Yang   +8 more
doaj   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin [PDF]

The Korean Journal of Parasitology, 2005
Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective.
Seokjoon, Lee, Sangtae, Oh, Gab-Man, Park, Tong-Soo, Kim, Jae-Sook, Ryu, Han-Kyu, Choi   +5 more
openaire   +2 more sources

Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis

Frontiers in Molecular Biosciences, 2023
The clinical therapeutics of cervical cancer is limited due to the drug resistance and metastasis of tumor. As a novel target for antitumor therapy, ferroptosis is deemed to be more susceptible for those cancer cells with resistance to apoptosis and ...
Hanqiang Shi, Hanqiang Shi, Lie Xiong, Lie Xiong, Guang Yan, Shuqin Du, Shuqin Du, Jie Liu, Yanbo Shi, Yanbo Shi   +9 more
doaj   +1 more source

Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer

Phytotherapy Research, EarlyView.
Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer. ABSTRACT Dihydroartemisinin (DHA), a bioactive derivative of Artemisia annua L. (AAL), has shown antitumor activity in several malignancies, including non‐small cell lung cancer (NSCLC).
Xiuli Guo, Gan Tao, Mini Zhang, Linzhi Han, Sisi Yan, Chunsheng Wang, Jianguo Zhang, Xiaowan Guo, Kehua Hu, Yan Gong, Qiuji Wu, Conghua Xie   +11 more
wiley   +1 more source