Results 41 to 50 of about 11,186 (206)

Nanostructured Dihydroartemisinin Plus Epirubicin Liposomes Enhance Treatment Efficacy of Breast Cancer by Inducing Autophagy and Apoptosis

Nanomaterials, 2018
The heterogeneity of breast cancer and the development of drug resistance are the relapse reasons of disease after chemotherapy. To address this issue, a combined therapeutic strategy was developed by building the nanostructured dihydroartemisinin plus ...
Ying-Jie Hu, Jing-Ying Zhang, Qian Luo, Jia-Rui Xu, Yan Yan, Li-Min Mu, Jing Bai, Wan-Liang Lu   +7 more
doaj   +1 more source

Simple field assays to check quality of current artemisinin-based antimalarial combination formulations. [PDF]

, 2009
INTRODUCTION: Malaria continues to be one of the major public health problems in Africa, Asia and Latin America. Artemisinin derivatives (ARTs; artesunate, artemether, and dihydroartemisinin) derived from the herb, Artemisia annua, are the most effective
Ioset, Jean-Robert, Kaur, Harparkash, Harparkash Kaur, Kaur Harparkash, Jean-Robert Ioset, Ioset Jean-Robert   +5 more
core   +2 more sources

Effect of dihydroartemisinin on the adhesion, migration, invasion, and epithelial-mesenchymal transition of human hepatocellular carcinoma cells and its mechanism [PDF]

精准医学杂志
Objective To investigate the effect of dihydroartemisinin on the adhesion, migration, invasion, and epithe-lial-mesenchymal transition (EMT) of human hepatocellular carcinoma HCCLM3 cells and to elucidate its mechanism.
ZHU Yanju, ZHOU Jian, FENG Mingming, GUO Shengli
doaj   +1 more source

Nevirapine-Based Antiretroviral Therapy Impacts Artesunate and Dihydroartemisinin Disposition in HIV-Infected Nigerian Adults

AIDS Research and Treatment, 2012
Background. Nevirapine- (NVP-) based antiretroviral therapy (ART) and artesunate-amodiaquine are frequently coprescribed in areas of HIV and malaria endemicity. We explored the impact of this practice on artesunate and dihydroartemisinin pharmacokinetics.
Fatai A. Fehintola, Kimberly K. Scarsi, Qing Ma, Sunil Parikh, Gene D. Morse, Babafemi Taiwo, Ibrahim Tope Akinola, Isaac F. Adewole, Niklas Lindegardh, Aphiradee Phakderaj, Oladosu Ojengbede, Robert L. Murphy, Olusegun O. Akinyinka, Francesca T. Aweeka   +13 more
doaj   +1 more source

Estimation of dihydroartemisinin in human plasma using a highly sensitive LTQ Orbitrap mass spectrometer with Xcalibur software

Frontiers in Pharmacology, 2023
Background: Artemether (ARM), the O-methyl ether prodrug of dihydroartemisinin (DHA), is considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its active metabolite DHA, and therefore its determination offers ...
Tareq Abu-Izneid, Muhammad Abbas, David G. Watson, Yasar Shah, Sayyed I. Shah, Fazli Khuda   +5 more
doaj   +1 more source

Dihydroartemisinin: A Potential Natural Anticancer Drug [PDF]

International Journal of Biological Sciences, 2021
Dihydroartemisinin (DHA) is an active metabolite of artemisinin and its derivatives (ARTs), and it is an effective clinical drug widely used to treat malaria. Recently, the anticancer activity of DHA has attracted increasing attention. Nevertheless, there is no systematic summary on the anticancer effects of DHA.
Dai, Xiaoshuo, Zhang, Xiaoyan, Chen, Wei, Chen, Yihuan, Zhang, Qiushuang, Mo, Saijun, Lu, Jing   +6 more
openaire   +2 more sources

Prospective observational study to evaluate the clinical safety of the fixed-dose artemisinin-based combination Eurartesim® (dihydroartemisinin/piperaquine), in public health facilities in Burkina Faso, Mozambique, Ghana, and Tanzania. [PDF]

, 2015
BACKGROUND: The World Health Organization recommends artemisinin-based combination (ACT) for the treatment of uncomplicated malaria. Post-licensure safety data on newly registered ACT is critical for evaluating their risk/benefit profile in malaria ...
Abdulla, Salim, Halidou, Tinto, Ogutu, Bernhards, Mulokozi, Abdunoor, Yawson, Abena, Adjuik, Martin, Baiden, Rita, Owusu-Agyei, Seth, Akparibo, Raymond, Valea, Innocent, Gyapong, Margaret, Macete, Eusebio, Sevene, Esperanca, Smith, Peter, Binka, Fred, Adjei, Alex, Osei, Isaac, Compaoré, Guillaume, Upunda, Gabriel Leonard, Oduro, Abraham, Sie, Ali   +20 more
core   +1 more source

Design, Synthesis, and Mechanism of Dihydroartemisinin–Coumarin Hybrids as Potential Anti-Neuroinflammatory Agents

Molecules, 2019
Cancer patients frequently suffer from cancer-related fatigue (CRF), which is a complex syndrome associated with weakness and depressed mood. Neuroinflammation is one of the major inducers of CRF.
Haonan Yu, Zhuang Hou, Xiaoguang Yang, Yanhua Mou, Chun Guo   +4 more
doaj   +1 more source

Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma

Frontiers in Pharmacology, 2020
Osteosarcoma cellular iron concentration is higher than that in normal bone cells and other cell types. High levels of cellular iron help catalyze the Fenton reaction to produce reactive oxygen species (ROS), which promotes cancer cell proliferation ...
Ying Shen, Ying Shen, Ying Shen, Bin Zhang, Bin Zhang, Bin Zhang, Yanwei Su, Yanwei Su, Yanwei Su, Shaikh Atik Badshah, Shaikh Atik Badshah, Xiaofei Wang, Xin Li, Xin Li, Xin Li, Yanru Xue, Yanru Xue, Yanru Xue, Li Xie, Li Xie, Zhe Wang, Zhe Wang, Zhouqi Yang, Zhouqi Yang, Ge Zhang, Peng Shang, Peng Shang   +26 more
doaj   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]

, 2010
The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Färnert, Anna, Zul Premji, Mårtensson, A, Annerberg, A, Mårtensson, Andreas, Annerberg, A., Andreas Mårtensson, Martensson, A., Bjorkman, A., Ngasala, B., Lindegårdh, N, Hietala, Sofia Friberg, Ngasala, B, Ashton, M., Dahlström, S, Gil, P, Friberg Hietala, Sofia,, Björkman, A, Premji, Z., Björkman, Anders, Sofia Friberg Hietala, Premji, Zul, Farnert, A., Dahlström, Sabina, Hietala, SF, Anna Annerberg, Annerberg, Anna, Anders Björkman, Anna Färnert, Pedro Gil, Lindegårdh, Niklas, Ashton, M, Ngasala, Billy, Michael Ashton, Färnert, A, Niklas Lindegårdh, Dahlstrom, S., Gil, P., Billy Ngasala, Lindegardh, N., Ashton, Michael, Gil, J. P., Premji, Z, Gil, Pedro, Hietala, S.F., Ashton, Michael,, Sabina Dahlström   +46 more
core   +1 more source