Results 41 to 50 of about 3,994 (169)

Bioequivalence of Two Intravenous Artesunate Products with Its Active Metabolite Following Single and Multiple Injections

Pharmaceuticals, 2011
In animal species and humans, artesunate (AS) undergoes extensive and complex biotransformation to an active metabolite, dihydroartemisinin (DHA). The bioequivalence of two intravenous AS pharmaceutical products with 5% NaHCO3 (China Formulation) or 0.3 ...
Qigui Li, Lisa Xie, Peter Weina, Victor Melendez   +3 more
doaj   +1 more source

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.

, 2006
In Rwanda, amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) is the current first-line treatment for malaria, introduced in 2001 as an interim strategy before the future deployment of an artemisinin-based combination treatment (ACT).
Karema, Corine, Ngamije, D., D'Alessandro, U., Fanello, C. I., van Doren, W., Karema, C., Fanello, Caterina I, Fanello, Caterina I., D'Alessandro, Umberto, Van Overmeir, C., d' Alessandro, Umberto, van Geertruyden, Jean-Pierre, Ngamije, Daniel, van Overmeir, Chantal, van Doren, Walli, Van Geertruyden, J. P.   +15 more
core   +1 more source

Design, Synthesis and Evaluation of the Antibacterial Enhancement Activities of Amino Dihydroartemisinin Derivatives

Molecules, 2013
Artemisinin (ART) and its derivatives artesunate (AS), dihydroartemisinin (DHA) are a group of drugs containing a sesquiterpene lactone used to treat malaria.
Dacheng Yang, Jingfang Wang, Wei Peng, Bin Li, Wenying Xian, Xichun Pan, Jian Liu, Chong Wu, Hong Zhou   +8 more
doaj   +1 more source

Human Telomerase Reverse Transcriptase as a Therapeutic Target of Dihydroartemisinin for Esophageal Squamous Cancer

Frontiers in Pharmacology, 2021
Objective: To elucidate the oncogenic role of human telomerase reverse transcriptase (hTERT) in esophageal squamous cancer and unravel the therapeutic role and molecular mechanism of dihydroartemisinin (DHA) by targeting hTERT.Methods: The expression of ...
Qingrong Li, Qingrong Li, Qingrong Li, Qiang Ma, Qiang Ma, Qiang Ma, Lei Xu, Chuanli Gao, Chuanli Gao, Chuanli Gao, Lihua Yao, Lihua Yao, Lihua Yao, Jilin Wen, Jilin Wen, Jilin Wen, Miyuan Yang, Miyuan Yang, Miyuan Yang, Jibing Cheng, Jibing Cheng, Jibing Cheng, Xi Zhou, Xi Zhou, Xi Zhou, Jiang Zou, Jiang Zou, Jiang Zou, Xiaowu Zhong, Xiaowu Zhong, Xiaowu Zhong, Xiaolan Guo, Xiaolan Guo, Xiaolan Guo   +33 more
doaj   +1 more source

Dihydroartemisinin-Loaded Chitosan Nanoparticles Inhibit the Rifampicin-Resistant Mycobacterium tuberculosis by Disrupting the Cell Wall

Frontiers in Microbiology, 2021
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is a deadly infection, and increasing resistance worsens an already bad scenario. In this work, a new nanomedicine antibacterial agent, based on dihydroartemisinin (DHA) and chitosan (CS), has ...
Xiujuan Gu, Xiujuan Gu, Qi Cheng, Ping He, Yan Zhang, Zhengfang Jiang, Yali Zeng   +6 more
doaj   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Dihydroartemisinin induces pyroptosis and regulates apoptosis-associated speck-like protein methylation in prostate cancer cells

陆军军医大学学报, 2022
Objective To investigate the effect of dihydroartemisinin (DHA) on pyroptosis in prostate cancer (PCa) cells and the underlying possible mechanism. Methods PCa cell lines PC-3 and DU145 were divided into control group and DHA treatment group (50 μmol/L ...
ZHOU Sijie, LIU Sihao, YANG Jiaxin, HUANG Yanping   +3 more
doaj   +1 more source

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

Tafenoquine co-administered with dihydroartemisinin–piperaquine for the radical cure of Plasmodium vivax malaria (INSPECTOR): a randomised, placebo-controlled, efficacy and safety study [PDF]

, 2023
Background: Tafenoquine, co-administered with chloroquine, is approved for the radical cure (prevention of relapse) of Plasmodium vivax malaria. In areas of chloroquine resistance, artemisinin-based combination therapies are used to treat malaria.
J Kevin Baird, Stephan Duparc, Lenny L Ekawati, Justin A Green, Instiaty Instiaty, Hema Sharma, Ana Martin, Lionel K Tan, Inge Sutanto, Rintis Noviyanti, Siôn Jones, Navin Goyal, Catur Bidik Prasetya, Katie Rolfe, Yulia Widya Santy, Alessandro Berni, Iqbal Elyazar, Jörg-Peter Kleim, Maxine Taylor, Decy Subekti, Ari Winasti Satyagraha, Chelzie Crenna-Darusallam, Amin Soebandrio, Waras Budiman, Soroy Lardo, Eve Cedar, Krisin Chand, Kim Fletcher, Disala Fernando   +28 more
core   +1 more source

Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda.

PLoS Medicine
BackgroundTo mitigate adverse consequences of malaria in pregnancy, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine.
Abel Kakuru, Jimmy Kizza, Miriam Aguti, Harriet Adrama, John Ategeka, Peter Olwoch, Miriam Nakalembe, Joaniter I Nankabirwa, Bishop Opira, Nida Ozarslan, Anju Ranjit, Erin Dela Cruz, Tamara D Clark, Michelle E Roh, Stephanie L Gaw, Prasanna Jagannathan, Philip J Rosenthal, Moses R Kamya, Grant Dorsey   +18 more
doaj   +1 more source