Results 31 to 40 of about 3,994 (169)

Effect of dihydroartemisinin on the adhesion, migration, invasion, and epithelial-mesenchymal transition of human hepatocellular carcinoma cells and its mechanism [PDF]

精准医学杂志
Objective To investigate the effect of dihydroartemisinin on the adhesion, migration, invasion, and epithe-lial-mesenchymal transition (EMT) of human hepatocellular carcinoma HCCLM3 cells and to elucidate its mechanism.
ZHU Yanju, ZHOU Jian, FENG Mingming, GUO Shengli
doaj   +1 more source

Design, Synthesis and Anti-Lung Cancer Evaluation of 1, 2, 3-Triazole Tethered Dihydroartemisinin-Isatin Hybrids

Frontiers in Pharmacology, 2021
A series of 1,2,3-triazole tethered dihydroartemisinin-isatin hybrids 8a-c and 9a-k were designed and synthesized. Their antiproliferative activity against A549, doxorubicin-resistant A549 (A549/DOX) as well as cisplatin-resistant A549 (A549/DDP) lung ...
Haodong Hou, Bin Qu, Chen Su, Guihua Hou, Feng Gao   +4 more
doaj   +1 more source

Co-Delivery of Dihydroartemisinin and Indocyanine Green by Metal-Organic Framework-Based Vehicles for Combination Treatment of Hepatic Carcinoma

Pharmaceutics, 2022
Dihydroartemisinin (DHA), a widely used antimalarial agent, has clinical potential for the treatment of hepatic carcinoma. Although chemotherapy is indispensable for tumor therapy, it is generally limited by poor solubility, low efficiency, rapid ...
Yang Chen, Bin Wang, Wenping Chen, Tao Wang, Min Li, Zucheng Shen, Fang Wang, Jing Jia, Fenglan Li, Xiangyu Huang, Junyang Zhuang, Ning Li   +11 more
doaj   +1 more source

A Simplified Liquid Chromatography-Mass Spectrometry Assay for Artesunate and Dihydroartemisinin, Its Metabolite, in Human Plasma

Molecules, 2010
Artesunate (AS) is a potent antimalarial that is used worldwide for the treatment of malaria. A simple method with a total run time of 12 min was developed and validated for the quantification of AS and dihydroartemisinin (DHA), its active metabolite, in
Victor Meléndez, Peter J. Weina, Mark M. Fukuda, Srisombat Wannaying, Robert S. Miller, David Saunders, Apassorn Lim, Nitima Chanarat, Roongnapa Apinan, Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Raveewan Siripokasupkul   +11 more
doaj   +1 more source

Three-Carbon Linked Dihydroartemisinin-Isatin Hybrids: Design, Synthesis and Their Antiproliferative Anticancer Activity

Frontiers in Pharmacology, 2022
Fifteen dihydroartemisinin-isatin hybrids (5a-e and 6a-j) linked with three-carbon were designed, synthesized. The antiproliferative activity against lung cancer cell lines including drug-sensitive A549, doxorubicin-resistant A549 (A549/DOX) and ...
Min Dong, Guili Zheng, Feng Gao, Min Li, Chen Zhong   +4 more
doaj   +1 more source

Dihydroartemisinin: A Potential Natural Anticancer Drug [PDF]

International Journal of Biological Sciences, 2021
Dihydroartemisinin (DHA) is an active metabolite of artemisinin and its derivatives (ARTs), and it is an effective clinical drug widely used to treat malaria. Recently, the anticancer activity of DHA has attracted increasing attention. Nevertheless, there is no systematic summary on the anticancer effects of DHA.
Dai, Xiaoshuo, Zhang, Xiaoyan, Chen, Wei, Chen, Yihuan, Zhang, Qiushuang, Mo, Saijun, Lu, Jing   +6 more
openaire   +2 more sources

Assessment of the effect of dihydroartemisinin-sodium valproate combination on some behavioural activities in mice [PDF]

, 2015
Co-morbidity inevitably warrant occurrence of polypharmacy that may result in interactions or modification of either the therapeutic or toxic effect of any of the drugs employed.
Malami, S, Ya’u, J, Ahmadu, H, Yaro, AH, Idris, AG   +4 more
core   +1 more source

Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy

Drug Delivery, 2020
Dihydroartemisinin (DHA) is a potent anti-cancer drug that has limited clinical applications due to poor water solubility and low bioavailability. We designed a biodegradable poly(ethylene glycol) methyl ether-poly(ε-caprolactone) (MPEG-PCL) micelle ...
Yun Lu, Qian Wen, Jia Luo, Kang Xiong, ZhouXue Wu, BiQiong Wang, Yue Chen, Bo Yang, ShaoZhi Fu   +8 more
doaj   +1 more source

New Uses for Old Drugs: The Tale of Artemisinin Derivatives in the Elimination of Schistosomiasis Japonica in China

Molecules, 2014
Artemisinin (qinghaosu), extracted from the Chinese herb Artemisia annua L. in 1972, and its three major derivatives—artemether, artesunate and dihydroartemisinin—were firstly identified as antimalarials and found active against all species of the ...
Yi-Xin Liu, Wei Wu, Yue-Jin Liang, Zu-Liang Jie, Hui Wang, Wei Wang, Yi-Xin Huang   +6 more
doaj   +1 more source

Therapeutic potential of artemisinin and its derivatives in managing kidney diseases

Frontiers in Pharmacology, 2023
Artemisinin, an antimalarial traditional Chinese herb, is isolated from Artemisia annua. L, and has shown fewer side effects. Several pieces of evidence have demonstrated that artemisinin and its derivatives exhibited therapeutic effects on diseases like
Qi Jin, Tongtong Liu, Danqian Chen, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Ping Li, Yongli Zhan   +8 more
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