Results 11 to 20 of about 3,994 (169)

The pharmaceutical death-ride of dihydroartemisinin [PDF]

Malaria Journal, 2010
In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies. However, experimental testing demonstrates that, due to its intrinsic chemical instability, dihydroartemisinin is not suitable to ...
Jansen Frans, Frans Jansen, Frans Herwig Jansen   +2 more
openaire   +5 more sources

Choreoathetosis – an unusual adverse effect of dihydroartemisinin-piperaquine: a case report

Journal of Medical Case Reports, 2017
Background Dihydroartemisinin-piperaquine is a combination of dihydroartemisinin and piperaquine which is highly effective in the treatment of uncomplicated falciparum malaria. Its adverse effects are generally tolerable and temporary.
Benjamin Momo Kadia, Christian Morfaw, Armelle Corrine Gounoue Simo   +2 more
doaj   +2 more sources

Mechanisms of Dihydroartemisinin and Dihydroartemisinin/Holotransferrin Cytotoxicity in T-Cell Lymphoma Cells [PDF]

PLOS ONE, 2015
The validated therapeutic effects of dihydroartemisinin (DHA) in solid tumors have encouraged us to explore its potential in treating T-cell lymphoma. We found that Jurkat cells (a T-cell lyphoma cell line) were sensitive to DHA treatment with a IC50 of dihydroartemisinin.
Qiuyan Wang, Shaoling Wu, Xindong Zhao, Chunting Zhao, Hongguo Zhao, Lanfen Huo   +5 more
openaire   +5 more sources

Reappraising the cardiosafety of dihydroartemisinin-piperaquine [PDF]

The Lancet Infectious Diseases, 2018
The arsenal of efficacious drugs for the treatment of malaria remains small and is clearly insufficient to tackle the global burden of malaria, with more than 216 million clinical episodes and nearly half a million deaths annually.1 Among the new antimalarials that have been developed in the past decade, the artemisinin-based combination ...
Millat Martínez, Pere, Bassat Orellana, Quique   +1 more
openaire   +5 more sources

Nevirapine-Based Antiretroviral Therapy Impacts Artesunate and Dihydroartemisinin Disposition in HIV-Infected Nigerian Adults

AIDS Research and Treatment, 2012
Background. Nevirapine- (NVP-) based antiretroviral therapy (ART) and artesunate-amodiaquine are frequently coprescribed in areas of HIV and malaria endemicity. We explored the impact of this practice on artesunate and dihydroartemisinin pharmacokinetics.
Fatai A. Fehintola, Kimberly K. Scarsi, Qing Ma, Sunil Parikh, Gene D. Morse, Babafemi Taiwo, Ibrahim Tope Akinola, Isaac F. Adewole, Niklas Lindegardh, Aphiradee Phakderaj, Oladosu Ojengbede, Robert L. Murphy, Olusegun O. Akinyinka, Francesca T. Aweeka   +13 more
doaj   +2 more sources

Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine [PDF]

Malaria Journal, 2010
Background Artemether-lumefantrine is one of the most widely used anti-malarial drug combinations in the world with excellent tolerability and cure rates in adult and paediatric patients with uncomplicated falciparum malaria. The aim of this study was to
Tarning Joel, Najmi Muzammil H, Ali Shabana, Lindegardh Niklas   +3 more
doaj   +2 more sources

Dihydroartemisinin Suppresses Proliferation of Oral Squamous Cell Carcinoma Cells by Promoting Autophagy

Zhongliu Fangzhi Yanjiu
Objective To investigate the effect of dihydroartemisinin (DHC) on the proliferation capacity of human oral squamous carcinoma cells and its mechanism of action.
ZHANG Dan, ZHANG Hao, HE Li
doaj   +2 more sources

Correction: Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia [PDF]

, 2023
Correction to: "Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection ...
Solomon, Hiwot, Hwang, Jimee, Zhou, Zhiyong, Teka, Hiwot, Murphy, Matthew, Tasew, Geremew, Ezema, Bryan, Abera, Adugna, Tadesse, Mekonnen, Minta, Anna A., Assefa, Ashenaf, Sime, Heven, Girma, Samuel, Tadesse, Yehualashet, Bekele, Worku, Mohammed, Hussein, Dilu, Dereje, Svigel, Samaly Souza, Moriarty, Leah F., Anand, Anjoli, Haile, Mebrahtom, Alemayehu, Bereket Hailegiorgis, Etana, Kebede, Woyessa, Adugna   +23 more
core   +1 more source

Resistance to Dihydroartemisinin

Emerging Infectious Diseases, 2006
To the Editor: The emergence of widespread resistance to chloroquine and sulfadoxine-pyrimethamine in Africa has caused a sharp rise in deaths from malaria. The World Health Organization therefore urgently recommends replacement of these drugs, particularly with combinations that include an artemisinin compound (AC) (1). In 2006, although >40 countries
Cojean, Sandrine, Hubert, Veronique, Le Bras, Jacques, Durand, Remy   +3 more
openaire   +4 more sources

A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru [PDF]

, 2007
Background. Multi-drug resistant falciparum malaria is an important health problem in the Peruvian Amazon region. We carried out a randomised open label clinical trial comparing mefloquine-artesunate, the current first line treatment in this region, with
Casapia, M, Bernasconi, Andrea, Torres, Kathy, Grande, Tanilu, Erhart, Annette, Llanos-Cuentas, A., Umberto D'Alessandro, D'Alessandro Umberto, Caterina Fanello, Torres, K., Christopher Delgado, Grande, T., Casapia Martin, Casapia, M., D'Alessandro, U., Delgado, C, Fanello, C., Grande, T, Llanos-Cuentas Alejandro, Gamboa Dioni, Delgado Christopher, Erhart, A., Bernasconi, A., Tanilu Grande, Torres Kathy, Martin Casapia, Delgado, Christopher, Erhart, A, Fanello Caterina, Torres, K, Llanos-Cuentas, A, Andrea Bernasconi, Llanos-Cuentas, Alejandro, Delgado, C., Gamboa, Dioni, Bernasconi Andrea, Gamboa, D, Fanello, C, Fanello, Caterina, Gamboa, D., Bernasconi, A, Kathy Torres, Casapia, Martin, Alejandro Llanos-Cuentas, D'Alessandro, Umberto, Dioni Gamboa, Annette Erhart, D'Alessandro, U, Grande Tanilu, Erhart Annette   +49 more
core   +1 more source