Results 11 to 20 of about 11,186 (206)

Pilot study: bioequivalence of dihydroartemisinin in dihydroartemisinin-piperaquine tablet generic formulation in healthy Indonesian volunteers. [PDF]

Nagoya journal of medical science, 2023
Bioequivalence test should be carried out for copy medicine, including dihydroartemisinin-piperaquine (DHP), which is used to treat critical diseases requiring medication. To predict the bioequivalence of film coated DHP generic tablets compared to the reference, a randomized controlled trial, single blind, single dose cross over design, two sequences,
Isnawati, Ani, Gitawati, Retno, Alegantina, Sukmayati, Setyorini, Herni Asih   +3 more
openaire   +3 more sources

The pharmaceutical death-ride of dihydroartemisinin [PDF]

Malaria Journal, 2010
In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies. However, experimental testing demonstrates that, due to its intrinsic chemical instability, dihydroartemisinin is not suitable to ...
Jansen Frans, Frans Jansen, Frans Herwig Jansen   +2 more
openaire   +5 more sources

Application of the Triazolization Reaction to Afford Dihydroartemisinin Derivatives with Anti-HIV Activity

Molecules, 2017
Artemisinin and synthetic derivatives of dihydroartemisinin are known to possess various biological activities. Post-functionalization of dihydroartemisinin with triazole heterocycles has been proven to lead to enhanced therapeutic potential.
Sampad Jana, Shabina Iram, Joice Thomas, Muhammad Qasim Hayat, Christophe Pannecouque, Wim Dehaen   +5 more
doaj   +3 more sources

Reappraising the cardiosafety of dihydroartemisinin-piperaquine [PDF]

The Lancet Infectious Diseases, 2018
The arsenal of efficacious drugs for the treatment of malaria remains small and is clearly insufficient to tackle the global burden of malaria, with more than 216 million clinical episodes and nearly half a million deaths annually.1 Among the new antimalarials that have been developed in the past decade, the artemisinin-based combination ...
Millat Martínez, Pere, Bassat Orellana, Quique   +1 more
openaire   +5 more sources

Mechanisms of Dihydroartemisinin and Dihydroartemisinin/Holotransferrin Cytotoxicity in T-Cell Lymphoma Cells [PDF]

PLOS ONE, 2015
The validated therapeutic effects of dihydroartemisinin (DHA) in solid tumors have encouraged us to explore its potential in treating T-cell lymphoma. We found that Jurkat cells (a T-cell lyphoma cell line) were sensitive to DHA treatment with a IC50 of dihydroartemisinin.
Qiuyan Wang, Shaoling Wu, Xindong Zhao, Chunting Zhao, Hongguo Zhao, Lanfen Huo   +5 more
openaire   +5 more sources

Dihydroartemisinin–Piperaquine for the Prevention of Malaria in Pregnancy [PDF]

New England Journal of Medicine, 2016
Intermittent treatment with sulfadoxine-pyrimethamine is widely recommended for the prevention of malaria in pregnant women in Africa. However, with the spread of resistance to sulfadoxine-pyrimethamine, new interventions are needed.We conducted a double-blind, randomized, controlled trial involving 300 human immunodeficiency virus (HIV)-uninfected ...
Kakuru, Abel, Jagannathan, Prasanna, Muhindo, Mary K, Natureeba, Paul, Awori, Patricia, Nakalembe, Miriam, Opira, Bishop, Olwoch, Peter, Ategeka, John, Nayebare, Patience, Clark, Tamara D, Feeney, Margaret E, Charlebois, Edwin D, Rizzuto, Gabrielle, Muehlenbachs, Atis, Havlir, Diane V, Kamya, Moses R, Dorsey, Grant   +17 more
openaire   +6 more sources

The inhibitory effect of dihydroartemisinin on the growth of neuroblastoma cells [PDF]

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To evaluate the inhibitory effect of dihydroartemisinin on neuroblastoma cell line SH-SY5Y, explore the possible mechanism of dihydroartemisinin against neuroblastoma cells.
Ling Qi, Yang Yang, Yu-Cui Liu, Tian-Xin Zhu, Song Jin, Lin Zang, Yu-Ying Zhang, Kuang Ren   +7 more
doaj   +2 more sources

Dihydroartemisinin-cyclodextrin complexation: Solubility and stability

Archives of Pharmacal Research, 2009
Dihydroartemisinin (DHA) is a major metabolite of artemisinin and its derivatives, including arteether, artemether, and artesunate. To improve the solubility and stability of poorly soluble DHA, we prepared inclusion complexes with hydroxypropyl-beta-cyclodextrin (HPbetaCD) and recrystalized DHA to study its thermal stability.
Ansari, M., Iqbal, I., Sunderland, Bruce
openaire   +4 more sources

Assessment of the neurotoxicity of oral dihydroartemisinin in mice

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2002
High doses of the oil-soluble antimalarial artemisinin derivatives artemether and arteether, given by intramuscular injection to experimental mammals, produce an unusual pattern of selective damage to brainstem centres predominantly involved in auditory processing and vestibular reflexes.
Nontprasert, A, Pukrittayakamee, S, Prakongpan, S, Supanaranond, W, Looareesuwan, S, White, N   +5 more
openaire   +3 more sources

Effect of Food on the Pharmacokinetics of Piperaquine and Dihydroartemisinin

Clinical Drug Investigation, 2015
Piperaquine-dihydroartemisinin combination therapy has established efficacy for the treatment of malaria; however, a more comprehensive understanding of the pharmacokinetic properties and factors contributing to inter- and intra-individual variability is critical to optimize clinical use.
Reuter, S., Evans, A., Shakib, S., Lungershausen, Y., Francis, B., Valentini, G., Bacchieri, A., Ubben, D., Pace, S.   +8 more
openaire   +5 more sources