Results 1 to 10 of about 8,294 (131)

Targeting the NR3C1-ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer. [PDF]

Cancer Sci
The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Yang J, Chen P, Zheng Y, Shi F, Wang M, Xu L, Wei X, Wang X.   +7 more
europepmc   +2 more sources

Development of a Disease-Specific Virtual Malaria Population for Physiologically-Based Pharmacokinetic Modeling. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Malaria remains a major global health challenge, with an urgent need for new therapies to combat the evolving resistance to anti‐malarial treatments. Physiologically‐based pharmacokinetic (PBPK) modeling offers a promising approach to accurately predict PK, optimize dosing strategies, reduce development time and cost, and de‐risk the ...
Ding J, Pei Q, Hoglund RM, Tarning J.
europepmc   +2 more sources

Effects of dietary dihydroartemisinin on growth performance, meat quality, and antioxidant capacity in broiler chickens

Poultry Science
This study aimed to investigate the effects of dietary dihydroartemisinin on the growth performance, meat quality, and antioxidant capacity of broiler chickens.
Hao Zhang, Jingfei Zhang
exaly   +3 more sources

Development of R 8 modified epirubicin–dihydroartemisinin liposomes for treatment of non-small-cell lung cancer

Artificial Cells, Nanomedicine and Biotechnology, 2019
Presently, there are no few anticancer drugs that have been used clinically due to their poor targeting ability, short half-life period, non-selective distributions, generation of vasculogenic mimicry (VM) channels, high metastasis, and high recurrence ...
Xuetao Li, Rui-Jun Ju
exaly   +3 more sources

Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda. [PDF]

PLoS Medicine
BackgroundTo mitigate adverse consequences of malaria in pregnancy, the World Health Organization recommends intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine.
Abel Kakuru, Jimmy Kizza, Miriam Aguti, Harriet Adrama, John Ategeka, Peter Olwoch, Miriam Nakalembe, Joaniter I Nankabirwa, Bishop Opira, Nida Ozarslan, Anju Ranjit, Erin Dela Cruz, Tamara D Clark, Michelle E Roh, Stephanie L Gaw, Prasanna Jagannathan, Philip J Rosenthal, Moses R Kamya, Grant Dorsey   +18 more
doaj   +2 more sources

Artemisia annua and A. afra Teas, Artemisinin, and Dihydroartemisinin Differentially Regulate ROS and Fibrosis-Associated Phenotypes in Human Dermal Fibroblasts [PDF]

Molecules
Fibrosis is driven by persistent fibroblast activation, oxidative stress, myofibroblast differentiation, and extracellular matrix remodeling, yet available antifibrotic therapies remain limited.
Samuel Isife, Trevor Bush, Isha Medasani, Melissa Towler, Pamela Weathers   +4 more
doaj   +2 more sources

The effects of polysaccharides from Inonotus obliquus, artemisinin, and dihydroartemisinin on the reproductive system of male mice infected with Neospora caninum [PDF]

Frontiers in Veterinary Science
The present study investigated the protective effects of Inonotus obliquus polysaccharides (IOPs), artemisinin, and dihydroartemisinin (DHA) on Neospora caninum-induced damage of the reproductive system in male BALB/c mice.
Jianhao Zhao, Fanglin Zhao, Yang Liang, Zhenyu Wang, Pengfei Min, Yixuan Jin, Lu Li, Zhen Ma, Yang Wang, Xin Zhang, Siyuan Han, Lijun Jia   +11 more
doaj   +2 more sources

Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy

Drug Delivery, 2020
Dihydroartemisinin (DHA) is a potent anti-cancer drug that has limited clinical applications due to poor water solubility and low bioavailability. We designed a biodegradable poly(ethylene glycol) methyl ether-poly(ε-caprolactone) (MPEG-PCL) micelle ...
Biqiong Wang, Shaozhi Fu, Zhouxue Wu
exaly   +2 more sources

Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. [PDF]

PLoS ONE, 2012
Artemisinin and its main active metabolite dihydroartemisinin, clinically used antimalarial agents with low host toxicity, have recently shown potent anticancer activities in a variety of human cancer models.
Qian Ba, Naiyuan Zhou, Juan Duan, Tao Chen, Miao Hao, Xinying Yang, Junyang Li, Jun Yin, Ruiai Chu, Hui Wang   +9 more
doaj   +1 more source

Design, Synthesis and Anti-Lung Cancer Evaluation of 1, 2, 3-Triazole Tethered Dihydroartemisinin-Isatin Hybrids

Frontiers in Pharmacology, 2021
A series of 1,2,3-triazole tethered dihydroartemisinin-isatin hybrids 8a-c and 9a-k were designed and synthesized. Their antiproliferative activity against A549, doxorubicin-resistant A549 (A549/DOX) as well as cisplatin-resistant A549 (A549/DDP) lung ...
Haodong Hou, Bin Qu, Chen Su, Guihua Hou, Feng Gao   +4 more
doaj   +1 more source