Results 1 to 10 of about 3,994 (169)

Effects of Dietary Dihydroartemisinin on Growth Performance, Meat Quality, and Antioxidant Capacity in Broiler Chickens

Poultry Science
This study aimed to investigate the effects of dietary dihydroartemisinin on the growth performance, meat quality, and antioxidant capacity of broiler chickens.
Hao Zhang, Jingfei Zhang, Xiaoxiao Pu
exaly   +4 more sources

Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. [PDF]

PLoS ONE, 2012
Artemisinin and its main active metabolite dihydroartemisinin, clinically used antimalarial agents with low host toxicity, have recently shown potent anticancer activities in a variety of human cancer models.
Qian Ba, Naiyuan Zhou, Juan Duan, Tao Chen, Miao Hao, Xinying Yang, Junyang Li, Jun Yin, Ruiai Chu, Hui Wang   +9 more
doaj   +2 more sources

The inhibitory effect of dihydroartemisinin on the growth of neuroblastoma cells

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To evaluate the inhibitory effect of dihydroartemisinin on neuroblastoma cell line SH-SY5Y, explore the possible mechanism of dihydroartemisinin against neuroblastoma cells.
Ling Qi, Yang Yang, Yu-Cui Liu, Tian-Xin Zhu, Song Jin, Lin Zang, Yu-Ying Zhang, Kuang Ren   +7 more
doaj   +2 more sources

Estimation of dihydroartemisinin in human plasma using a highly sensitive LTQ Orbitrap mass spectrometer with Xcalibur software

Frontiers in Pharmacology, 2023
Background: Artemether (ARM), the O-methyl ether prodrug of dihydroartemisinin (DHA), is considered a first-line antimalarial agent. Artemether is extensively metabolized in vivo to its active metabolite DHA, and therefore its determination offers ...
Tareq Abu-Izneid, Muhammad Abbas, David G. Watson, Yasar Shah, Sayyed I. Shah, Fazli Khuda   +5 more
doaj   +1 more source

Dihydroartemisinin Exerts Antifibrotic and Anti-Inflammatory Effects in Graves’ Ophthalmopathy by Targeting Orbital Fibroblasts

Frontiers in Endocrinology, 2022
Graves’ ophthalmopathy (GO) is a common orbital disease that threatens visual function and appearance. Orbital fibroblasts (OFs) are considered key target and effector cells in GO.
Shenglan Yang, Xing Wang, Wei Xiao, Zhihui Xu, Huijing Ye, Xiaotong Sha, Huasheng Yang   +6 more
doaj   +1 more source

Targeted Lipid Nanoparticles Encapsulating Dihydroartemisinin and Chloroquine Phosphate for Suppressing the Proliferation and Liver Metastasis of Colorectal Cancer

Frontiers in Pharmacology, 2021
Antimalarial drugs Dihydroartemisinin (DHA) and chloroquine phosphate (CQ) exhibit evident anti-cancer activity, particularly as combination therapy. DHA and CQ combination therapy has been proved to exhibit higher cytotoxic effect in tumor cells and ...
Jianqing Peng, Jianqing Peng, Qin Wang, Qin Wang, Jia Zhou, Jia Zhou, Shuli Zhao, Shuli Zhao, Pan Di, Pan Di, Yan Chen, Yan Chen, Ling Tao, Ling Tao, Qianming Du, Qianming Du, Xiangchun Shen, Xiangchun Shen, Yi Chen, Yi Chen   +19 more
doaj   +1 more source

Application of the Triazolization Reaction to Afford Dihydroartemisinin Derivatives with Anti-HIV Activity

Molecules, 2017
Artemisinin and synthetic derivatives of dihydroartemisinin are known to possess various biological activities. Post-functionalization of dihydroartemisinin with triazole heterocycles has been proven to lead to enhanced therapeutic potential.
Sampad Jana, Shabina Iram, Joice Thomas, Muhammad Qasim Hayat, Christophe Pannecouque, Wim Dehaen   +5 more
doaj   +1 more source

Eliminating Radiation Resistance of Non-Small Cell Lung Cancer by Dihydroartemisinin Through Abrogating Immunity Escaping and Promoting Radiation Sensitivity by Inhibiting PD-L1 Expression

Frontiers in Oncology, 2020
Radiation resistance is linked to immune escaping and radiation sensitivity. In this study, we found that the PD-L1 expressions of non-killed tumor cells in NSCLC were enhanced after radiotherapy, and dihydroartemisinin (DHA) could synergistically ...
Hai Zhang, Fei Zhou, Yingying Wang, Huikang Xie, Shilan Luo, Lu Meng, Bin Su, Ying Ye, Kailiang Wu, Yaping Xu, Xiaomei Gong   +10 more
doaj   +1 more source

Combined Transcriptome and Proteome Profiling for Role of pfEMP1 in Antimalarial Mechanism of Action of Dihydroartemisinin

Microbiology Spectrum, 2021
Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in countries of endemicity.
Lina Chen, Zhongyuan Zheng, Hui Liu, Xi Wang, Shuiqing Qu, Yuanmin Yang, Shuoqiu Deng, Yu Zhang, Liu Tuo, Yongdan Zhao, Yujie Li   +10 more
doaj   +1 more source

Development of R8 modified epirubicin–dihydroartemisinin liposomes for treatment of non-small-cell lung cancer

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Presently, there are no few anticancer drugs that have been used clinically due to their poor targeting ability, short half-life period, non-selective distributions, generation of vasculogenic mimicry (VM) channels, high metastasis, and high recurrence ...
Jing-Jing Liu, Wei Tang, Min Fu, Xiao-Qing Gong, Liang Kong, Xue-Min Yao, Ming Jing, Fu-Yi Cai, Xue-Tao Li, Rui-Jun Ju   +9 more
doaj   +1 more source