Results 21 to 30 of about 11,186 (206)
Molecular evidence of incipient speciation within Anopheles gambiae s.s. in West Africa [PDF]
, 2001 We karyotyped and identified by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis Anopheles gambiae s.s. samples collected in several African countries. The data show the existence of two non-panmictic molecular forms,
Akogbeto, M +6 more
core +5 more sources
Pharmaceutics, 2022 Dihydroartemisinin (DHA), a widely used antimalarial agent, has clinical potential for the treatment of hepatic carcinoma. Although chemotherapy is indispensable for tumor therapy, it is generally limited by poor solubility, low efficiency, rapid ...
Yang Chen +11 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Fifteen dihydroartemisinin-isatin hybrids (5a-e and 6a-j) linked with three-carbon were designed, synthesized. The antiproliferative activity against lung cancer cell lines including drug-sensitive A549, doxorubicin-resistant A549 (A549/DOX) and ...
Min Dong +4 more
doaj +1 more source
Therapeutic potential of artemisinin and its derivatives in managing kidney diseases
Frontiers in Pharmacology, 2023 Artemisinin, an antimalarial traditional Chinese herb, is isolated from Artemisia annua. L, and has shown fewer side effects. Several pieces of evidence have demonstrated that artemisinin and its derivatives exhibited therapeutic effects on diseases like
Qi Jin +8 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Objective: To elucidate the oncogenic role of human telomerase reverse transcriptase (hTERT) in esophageal squamous cancer and unravel the therapeutic role and molecular mechanism of dihydroartemisinin (DHA) by targeting hTERT.Methods: The expression of ...
Qingrong Li +33 more
doaj +1 more source
Frontiers in Microbiology, 2021 Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is a deadly infection, and increasing resistance worsens an already bad scenario. In this work, a new nanomedicine antibacterial agent, based on dihydroartemisinin (DHA) and chitosan (CS), has ...
Xiujuan Gu +6 more
doaj +1 more source
Resistance to Dihydroartemisinin
Emerging Infectious Diseases, 2007 The original title of our article was “Lack of Plasmodium falciparum in Vitro and Genomic Resistance to Dihydroartemisinin in Travelers Returning to France from Africa.” EID’s shortening of the title (1) led to the perception that the letter title was misleading, but it was not on purpose.
Sandrine Cojean +8 more
openaire +3 more sources
A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru [PDF]
, 2007 Background. Multi-drug resistant falciparum malaria is an important health problem in the Peruvian Amazon region. We carried out a randomised open label clinical trial comparing mefloquine-artesunate, the current first line treatment in this region, with
Casapia, M +49 more
core +1 more source
陆军军医大学学报, 2022 Objective To investigate the effect of dihydroartemisinin (DHA) on pyroptosis in prostate cancer (PCa) cells and the underlying possible mechanism. Methods PCa cell lines PC-3 and DU145 were divided into control group and DHA treatment group (50 μmol/L ...
ZHOU Sijie +3 more
doaj +1 more source
Resistance to Dihydroartemisinin
Emerging Infectious Diseases, 2006 To the Editor: The emergence of widespread resistance to chloroquine and sulfadoxine-pyrimethamine in Africa has caused a sharp rise in deaths from malaria. The World Health Organization therefore urgently recommends replacement of these drugs, particularly with combinations that include an artemisinin compound (AC) (1). In 2006, although >40 countries
Sandrine Cojean +3 more
openaire +3 more sources