Results 121 to 130 of about 48,162 (258)

Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction

Redox Biology, 2019
Hypertension and abdominal aortic aneurysm (AAA) are severe cardiovascular diseases with incompletely defined molecular mechanisms. In the current study we generated dihydrofolate reductase (DHFR) knockout mice for the first time to examine its potential
Qiang Li, Ji Youn Youn, Kin Lung Siu, Priya Murugesan, Yixuan Zhang, Hua Cai   +5 more
doaj  

Crystal structure of dihydrofolate reductase from the emerging pathogenic fungus Candida auris. [PDF]

Acta Crystallogr D Struct Biol, 2023
Kirkman T, Sketcher A, de Morais Barroso V, Ishida K, Tosin M, Dias MVB.   +5 more
europepmc   +1 more source

Polymorphism of Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Genes Among Pregnant Women with Falciparum Malaria in Banjar District, South Kalimantan Province, Indonesia [PDF]

, 2012
Pregnant women are highly vulnerable to malaria infection in its endemic areas, particularly infection by Plasmodium falciparum that can cause premature, low birth weight, severe anemia in pregnant women, and death.
Basuki, S. (Sukmawati), Budiono, B. (Budiono), Dachlan, Y. P. (Yoes), Fitriah, F. (Fitriah), Riyanto, S. (Sugeng), Sulistyawati, S. (Sriwijayanti), Uemura, H. (Haruki)   +6 more
core  

INCREASED DIHYDROFOLATE REDUCTASE SYNTHESIS IN DIPLOCOCCUS PNEUMONIAE FOLLOWING TRANSLATABLE ALTERATION OF THE STRUCTURAL GENE. II. INDIVIDUAL AND DUAL EFFECTS ON THE PROPERTIES AND RATE OF SYNTHESIS OF THE ENZYME

, 1969
Francis M. Sirotnak, Sandra L Hachtel, Wendy A. Williams   +2 more
openalex   +2 more sources

Elongation Factor P Modulates the Incorporation of Structurally Diverse Noncanonical Amino Acids into Escherichia coli Dihydrofolate Reductase. [PDF]

J Am Chem Soc, 2023
Daskalova SM, Dedkova LM, Maini R, Talukder P, Bai X, Chowdhury SR, Zhang C, Nangreave RC, Hecht SM.   +8 more
europepmc   +1 more source

Dihydrofolate Reductase from a Resistant Subline of the L1210 Lymphoma

, 1967
John P. Perkins, Brian L. Hillcoat, Joseph R. Bertino   +2 more
openalex   +1 more source

NOX isoforms in the development of abdominal aortic aneurysm

Redox Biology, 2017
Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently established a causal role of uncoupled eNOS in this severe human disease.
Kin Lung Siu, Qiang Li, Yixuan Zhang, Jun Guo, Ji Youn Youn, Jie Du, Hua Cai   +6 more
doaj  

Methotrexate binding to dihydrofolate reductase [PDF]

Nature, 1980
P. Charlton, Douglas W. Young, Gordon C. K. Roberts, James Feeney, Berry Birdsall   +4 more
openaire   +3 more sources

Differentiating Properties of the Dihydrofolate Reductases of Amethopterin-resistant Streptococcus faecalis/Ak and the Sensitive Parent Strain

, 1966
A Albrecht, Jane L. Palmer, Dorris J. Hutchison   +2 more
openalex   +1 more source

The design and optimisation of novel human dihydrofolate reductase inhibitors for the management of proliferative disease [PDF]

, 2015
Tetrahydrofolate (THF) mediates DNA and RNA synthesis through production of purine and thymidylate precursors. During this process THF is reduced to the inactive dihydrofolate (DHF) and recycled back to the active DHF via a redox reaction, catalysed by ...
Portelli, Graziella, Shoemake, Claire
core