Results 121 to 130 of about 217,358 (308)

Cloning and expression of ricin a- and b-subunits genes in fusion constructions with dihydrofolate reductase gene in escheriсhia coli.

Тонкие химические технологии, 2007
Recombinant chimeric constructions RTA-DHFR and RTВ-DHFR consisting of ricin Aand B-subunits genes (RTA and RTB) and dihydrofolate reductase (DHFR) gene were cloned and expressed in Escheriсhia coli.
M. А. Gracheva, Z. М. Galushkina, N. N. Poletaeva, L. V. Verhovskaya, V. G. Lunin, V. I. Shvets   +5 more
doaj  

Pyrimido-Pyrimidines: A Novel Class of Dihydrofolate Reductase Inhibitors

Food Technology and Biotechnology, 2009
Inhibitors of dihydrofolate reductase (DHFR), an enzyme that catalyzes 5,6,7,8-tetrahydrofolate synthesis, have been used as antimicrobial as well as antimetabolite drugs for a long time. Although structurally belonging to different classes, the majority
Iva Tatic, Zrinka Ivezic, Sanja Tomic, Jerka Dumic, Mihailo Banjanac   +4 more
doaj  

Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

Scientia Pharmaceutica, 2017
Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for new anti-tuberculosis drugs. Fifteen crystal structures of Mycobacterium tuberculosis DHFR complexed with NADPH and various inhibitors are available in ...
Pimonluck Sittikornpaiboon, Pisanu Toochinda, Luckhana Lawtrakul   +2 more
doaj   +1 more source

Antibacterial Potential of Ximenia americana L. Olacaceae: Molecular Docking, Molecular Dynamics, and ADMET Prediction

Journal of Pharmacy
Introduction:  The devastating effect of persistent and recurrent bacterial infections coupled with antibiotic resistance is a driving force for prospects into alternative antibacterial therapeutics to achieve treatment.
Mubarak Muhammad Dahiru, Abdulazeez Mumsiri Abaka, Ibrahim Ya'u   +2 more
doaj   +1 more source

Control of synthesis of mRNA's for T4 bacteriophage-specific dihydrofolate reductase and deoxycytidylate hydroxymethylase [PDF]

, 1976
H Witmer, Anna Baros, D Ende, M Dosmar
openalex   +1 more source

Trimethoprim resistant dihydrofolate reductases in normal faecal flora isolated in India [PDF]

, 1994
Steven Tait, S. G. B. Amyes
openalex   +1 more source

Translocation arrest by reversible folding of a precursor protein imported into mitochondria [PDF]

, 1989
Passage of precursor proteins through translocation contact sites of mitochondria was investigated by studying the import of a fusion protein consisting of the NH2-terminal 167 amino acids of yeast cytochrome b2 precursor and the complete mouse ...
Guiard, Bernard, Hartl, Franz-Ulrich, Herzog, Volker, Neupert, Walter, Rassow, Joachim, Wienhues, Ulla   +5 more
core  

Genetic Diversity of Dihydropteroate synthetase Gene (dhps) Of Plasmodium vivax in Hormozgan Province, Iran

Iranian Journal of Parasitology, 2016
Background: The present study was formulated in order to determine pol­ymorphism of dihydropteroate synthetase gene (dhps) of Plasmodium vivax (P. vivax) in Hormozgan Province, southern Iran and mutations at codons 382, 383, 512, 553, and 585 associated ...
Somayeh MAGHSOODLOORAD, Ali HAGHIGHI, Khojasteh SHARIFI SARASIABI, Niloofar TAGHIPOOR, Nahid HOSSEINZADEH, Latif GACHKAR, Ehsan NAZEMALHOSSEINI MOJARRAD, Elham MAGHSOODLOORAD   +7 more
doaj  

Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling [PDF]

, 2009
Mark J. Crabtree, Amy L. Tatham, Ashley Hale, Nicholas J. C. King, Keith M. Channon   +4 more
openalex   +1 more source

A single-domain protein catenane of dihydrofolate reductase. [PDF]

Natl Sci Rev, 2023
Fang J, Li T, Lee J, Im D, Xu L, Liu Y, Seo J, Zhang WB.   +7 more
europepmc   +1 more source