Results 21 to 30 of about 217,358 (308)
International Journal of Mycobacteriology, 2016 Objectives/Background: Dihydrofolate reductase (DHFR) is one of the validated drug targets in Mycobacterium tuberculosis (Mtb) infection. DHFR inhibitors have been used to treat various life-threatening diseases such as cancer, malaria, and several ...
Mymoona Akhter
doaj +1 more source
A designed phenylalanyl-tRNA synthetase variant allows efficient in vivo incorporation of aryl ketone functionality into proteins [PDF]
, 2002 Incorporation of non-natural amino acids into proteins in vivo expands the scope of protein synthesis and design. p-Acetylphenylalanine was incorporated into recombinant dihydrofolate reductase (DHFR) in Escherichia coli via a computationally designed ...
Carrico, Isaac S. +4 more
core +2 more sources
Journal of Medicinal Chemistry, 2019 A safer treatment for toxoplasmosis would be achieved by improving the selectivity and potency of dihydrofolate reductase (DHFR) inhibitors, such as pyrimethamine (1), for Toxoplasma gondii DHFR ( TgDHFR) relative to human DHFR ( hDHFR).
Allen T. Hopper +8 more
semanticscholar +1 more source
Mining electron density for functionally relevant protein polysterism in crystal structures. [PDF]
, 2010 This review focuses on conceptual and methodological advances in our understanding and characterization of the conformational heterogeneity of proteins.
Fraser, James S, Jackson, Colin J
core +3 more sources
A trimethoprim derivative impedes antibiotic resistance evolution
Nature Communications, 2021 The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al.
Madhu Sudan Manna +15 more
doaj +1 more source
A novel bicyclic 2,4-diaminopyrimidine inhibitor of Streptococcus suis dihydrofolate reductase [PDF]
PeerJ, 2021 Streptococcus suis is a Gram-positive bacterial pathogen of pigs and an emerging zoonotic pathogen. It has become increasingly resistant to multiple classes of antibiotics.
Warangkhana Songsungthong +5 more
doaj +2 more sources
A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer*
Journal of Biological Chemistry, 2017 Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate. An increase in the cellular expression level of DHFR is one of the mechanisms of tumor resistance to methotrexate.
Masataka Nakano +3 more
semanticscholar +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 2016 In Iran, both Plasmodium vivax and P. falciparum malaria have been detected, but P. vivax is the predominant species. Point mutations in dihydrofolate reductase (dhfr) gene in both Plasmodia are the major mechanisms of pyrimethamine resistance.
Khojasteh SHARIFI-SARASIABI +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang +6 more
wiley +2 more sources
Scientific Reports, 2018 Malaria, caused by parasites of the genus Plasmodium, leads to over half a million deaths per year, 90% of which are caused by Plasmodium falciparum. P. vivax usually causes milder forms of malaria; however, P.
E. Bilsland +12 more
semanticscholar +1 more source