Results 51 to 60 of about 48,162 (258)

Genetics of human neural tube defects [PDF]

, 2009
Neural tube defects (NTDs) are common, severe congenital malformations whose causation involves multiple genes and environmental factors. Although more than 200 genes are known to cause NTDs in mice, there has been rather limited progress in delineating ...
A. J. Copp, Au, Beaudin, Beaudin, Bennett, Birn, Blom, Boyles, Brody, Brown, Carmichael, Carroll, Carroll, Chen, Chen, Chen, Christensen, Christensen, Cockroft, Copp, Copp, Dalal, Davidson, De Marco, De Marco, Deak, Deak, Detrait, Doudney, Dunlevy, Dunlevy, Elmore, Enaw, Epstein, Estibeiro, Etheridge, Franke, Frosst, Gelineau-van Waes, Gonzalez-Herrera, Gos, Greene, Greene, Greene, Greene, Gustavsson, Gustavsson, Harris, Harris, Jensen, Jensen, Jensen, Jessen, Joosten, Kennedy, Khandelwal, Kibar, Kibar, Kibar, Kibar, King, Kirke, Krasnow, Lakkis, Li, Li, Lorenz, Lu, Lu, Lu, McEwen, Mills, Mitchell, Molloy, Montcouquiol, Murdoch, Murdoch, Murdoch, N. D.E. Greene, Narimatsu, Neumann, O'Leary, O'leary, Okano, P. Stanier, Park, Parker, Parle-McDermott, Parle-McDermott, Qian, Relton, Relton, Scott, Shang, Shaw, Shields, Smithells, Stamm, Stamm, Steegers-Theunissen, Stegmann, Strutt, Strutt, Stumpf, Swanson, Swanson, Ting, Toepoel, Trembath, van der Linden, van der Linden, van der Linden, van der Linden, van der Put, van Straaten, Vanaerts, vandenBerg, Vieira, Volcik, Wallingford, Wang, Watanabe, Wilding, Wilson, Wu, Zhang, Zhu, Zhu, Zhu, Zhu, Zhu, Zohn   +131 more
core   +2 more sources

Genomic Insights Into a Strong Biofilm‐Forming Enterococcus faecalis MTR_EFS01 Strain Isolated From a Shrimp in Bangladesh

Animal Research and One Health, EarlyView.
This study characterizes a multidrug‐resistant and strong biofilm‐forming Enterococcus faecalis strain obtained from a shrimp sample in Bangladesh. ABSTRACT Enterococcus faecalis is known for its ability to form strong biofilms and its role as an opportunistic pathogen. In this study, we screened and characterized a multidrug‐resistant (MDR) and strong
Md. Ashek Ullah, Md. Saiful Islam, Md. Liton Rana, Jayedul Hassan, Md. Tanvir Rahman   +4 more
wiley   +1 more source

Polimorfismo de deleção de 19 pares de bases do gene dihidrofolato redutase (DHFR): risco materno para síndrome de Down e metabolismo do folato [PDF]

, 2010
CONTEXT AND OBJECTIVE: Polymorphisms in genes involved in folate metabolism may modulate the maternal risk of Down syndrome (DS). This study evaluated the influence of a 19-base pair (bp) deletion polymorphism in intron-1 of the dihydrofolate reductase ...
BISELLI, Joice Matos, CARVALHO, Valdemir Melechco, EBERLIN, Marcos Nogueira, GOLONI-BERTOLLO, Eny Maria, HADDAD, Renato, MENDES, Cristiani Cortez, PAVARINO-BERTELLI, Érika Cristina, RICCIO, Maria Francesca, VANNUCCHI, Hélio, ZAMPIERI, Bruna Lancia   +9 more
core   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Computer simulation of protein systems [PDF]

, 1984
Ligand binding to dihydrofolate reductase (DHFR) is discussed. This is an extremely important enzyme, as it is the target of several drugs (inhibitors) which are used clinically as antibacterials, antiprotozoals and in cancer chemotherapy. DHFR catalyzes
Dauber-Osguthorpe, P., Hagler, A. T., Kitson, D. H., Osguthorpe, D. J., Wolff, J.   +4 more
core   +1 more source

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, EarlyView.
SLIPT‐PM enables the translocation of tag‐fused proteins from the cytoplasm to the plasma membrane using a synthetic self‐localizing ligand. This user‐friendly system permits reversible control of diverse signaling pathways. This concept article highlights the key features and current applications of SLIPT‐PM as a powerful tool in chemical and ...
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source

Effect of Sunflower (Helianthus annuus L.) Seeds Treatment by Diode Laser Radiation in Seedlings and Calli Growth

مجلة مركز بحوث التقنيات الاحيائية, 2015
The effect of the exposure of sunflower (Helianthus annuus L.) seeds to red light laser radiation with 650 nm 50 mw/cm2 by diode laser in germination and growth of seedlings and calli had been studied.
Sara N. Ghanem Ghanem, Sajida A. Abood Abood   +1 more
doaj   +1 more source

Divergent evolution of protein conformational dynamics in dihydrofolate reductase. [PDF]

, 2013
Molecular evolution is driven by mutations, which may affect the fitness of an organism and are then subject to natural selection or genetic drift. Analysis of primary protein sequences and tertiary structures has yielded valuable insights into the ...
Bhabha, Gira, Dyson, H Jane, Ekiert, Damian C, Godzik, Adam, Jennewein, Madeleine, Kroon, Gerard, Tuttle, Lisa M, Wilson, Ian A, Wright, Peter E, Zmasek, Christian M   +9 more
core   +2 more sources

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Type 2 antifolates in the chemotherapy of falciparum malaria

Journal of the Brazilian Chemical Society, 2002
About 40% of the world population is exposed to malaria, which results in the death of over 2 million people per year in Africa, Latin America, Southern Asia and Oceania.
Delfino Reinaldo T., Santos-Filho Osvaldo A., Figueroa-Villar José D.   +2 more
doaj