Results 51 to 60 of about 23,186 (181)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

StabLyzeGraph: High‐throughput screening of combinatorial mutations using graph neural networks

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a broad range of applications such as atomic structure determination, discovery of therapeutic molecules, biomanufacturing, diagnostic reagents, industrial biocatalysis, etc.
Muhammad Waqas, Benito Natale, Michele Roggia, Prasenjit Prasad Saha, Mauro Mileni, Sandro Cosconati   +5 more
wiley   +1 more source

INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME

Vitae, 2009
Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful ...
Diego A. ZABALA, Bibiana ECAVARRÍA, Alejandro MARTÍNEZ   +2 more
doaj  

Asymmetric Negishi and Kumada Couplings

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
This review summarizes asymmetric Negishi and Kumada cross‐coupling reactions from the 1980s through 2025. It examines enantioselective and enantiospecific transformations catalyzed by nickel, palladium, and cobalt complexes , highlighting ligand design, mechanistic insights, and applications in constructing complex chiral molecules and natural ...
Rui‐Heng Wang, Aishun Ding, Ramon Rios
wiley   +1 more source

Flipping the Switch: Next‐Generation Chemo‐Optogenetics for Reversible Control of Biological Systems

ChemPhotoChem, Volume 10, Issue 3, March 2026.
Next‐generation chemo‐optogenetic systems use photoswitchable molecular glues for reversible, repeatable light control of protein proximity, enabling precise spatiotemporal modulation of signaling, organelle dynamics, and protein stability—opening avenues for in vivo studies and therapeutic applications.
Laura K. Herzog, Jun Zhang, Yao‐Wen Wu
wiley   +1 more source

Trans‐Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids

MedComm, Volume 7, Issue 3, March 2026.
Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni, Chenyin Cao, Yanlin Tian, Jinming Mu, He Tian, Zehua Wang, Shaohua Zhang, Mingjun Cao, Yuntian Yang, Wei Ling Florence Lim, Jingkang Cui, Huan Sun, Huan Miao, Yuan Wang, Jie Du, Timothy Kwok, Huan Chen, Sin Man Lam, Guanghou Shui   +18 more
wiley   +1 more source

Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction

Redox Biology, 2019
Hypertension and abdominal aortic aneurysm (AAA) are severe cardiovascular diseases with incompletely defined molecular mechanisms. In the current study we generated dihydrofolate reductase (DHFR) knockout mice for the first time to examine its potential
Qiang Li, Ji Youn Youn, Kin Lung Siu, Priya Murugesan, Yixuan Zhang, Hua Cai   +5 more
doaj   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

NOX isoforms in the development of abdominal aortic aneurysm

Redox Biology, 2017
Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently established a causal role of uncoupled eNOS in this severe human disease.
Kin Lung Siu, Qiang Li, Yixuan Zhang, Jun Guo, Ji Youn Youn, Jie Du, Hua Cai   +6 more
doaj   +1 more source

Society for Maternal‐Fetal Medicine Consult Series #76: Cancer in pregnancy

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Approximately one in 1000 pregnancies is complicated by the diagnosis of cancer each year, and the incidence of cancer among reproductive‐age individuals is increasing. Management of a pregnant person with cancer can be complex and warrants a multidisciplinary approach to care.
Society for Maternal‐Fetal Medicine (SMFM), Moti Gulersen, Clarissa Bonanno, Justin S. Brandt, Stephanie Pierce, Elyce H. Cardonick, SMFM Publications Committee   +6 more
wiley   +1 more source