Results 81 to 90 of about 217,358 (308)

Metabolite-dependent regulation of gene expression in trypanosoma brucei [PDF]

, 2013
Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans-splicing of large polycistronic ...
Archer, Batey, Besteiro, Birkholtz, Breaker, Carter, Clayton, Coustou, De Gaudenzi, Ebikeme, Fairlamb, Hendriks, Jacob, Jensen, Kabani, Lamour, Mangold, Martinez-Calvillo, Nguyen, Perez-Leal, Persson, Phillips, Stuart, Veitch, Vincent, Ward, Willert, Willert, Willert, Wirtz, Wurst, Wurst, Xiao, Xiao, Zhang   +34 more
core   +1 more source

Preservation of Protein Dynamics in Dihydrofolate Reductase Evolution*

Journal of Biological Chemistry, 2013
Background: “Humanized” mutants of bacterial dihydrofolate reductase were examined to relate protein dynamics with enzyme evolution. Results: Effects on enzyme dynamics alter the catalyzed C-H→C step, but the nature of that step was retained along ...
K. Francis, Vanja Stojković, A. Kohen
semanticscholar   +1 more source

A comprehensive overview of yeast libraries and their role in advancing cell biology

The FEBS Journal, EarlyView.
Systematic, genome‐wide yeast mutant libraries have revolutionized systems and cell biology. By allowing high‐throughput interrogation of every gene and protein, they have defined gene essentiality, charted protein localization, illuminated function, mapped interactions, and more.
Din Baruch, Maya Schuldiner, Ofir Klein
wiley   +1 more source

Inhibition of Leishmania Major PTR1 Gene Expression by Anti-sense in Escherichia Coli [PDF]

Iranian Journal of Public Health, 2012
Background:Protozoa related to Trypanosome family including Leishmania,synthesize enzymes to escape from drug therapy.One of them is PTR1 that its enzymatic activity is similar to dihydrofolate reductase(DHFR)Dihydrofolate reductase - thymidylate ...
M Mohebali, F Mahboudi, A Haghighi, M Bandehpour, F Kheirandish, B Kazemi   +5 more
doaj   +2 more sources

Genetics of human neural tube defects [PDF]

, 2009
Neural tube defects (NTDs) are common, severe congenital malformations whose causation involves multiple genes and environmental factors. Although more than 200 genes are known to cause NTDs in mice, there has been rather limited progress in delineating ...
A. J. Copp, Au, Beaudin, Beaudin, Bennett, Birn, Blom, Boyles, Brody, Brown, Carmichael, Carroll, Carroll, Chen, Chen, Chen, Christensen, Christensen, Cockroft, Copp, Copp, Dalal, Davidson, De Marco, De Marco, Deak, Deak, Detrait, Doudney, Dunlevy, Dunlevy, Elmore, Enaw, Epstein, Estibeiro, Etheridge, Franke, Frosst, Gelineau-van Waes, Gonzalez-Herrera, Gos, Greene, Greene, Greene, Greene, Gustavsson, Gustavsson, Harris, Harris, Jensen, Jensen, Jensen, Jessen, Joosten, Kennedy, Khandelwal, Kibar, Kibar, Kibar, Kibar, King, Kirke, Krasnow, Lakkis, Li, Li, Lorenz, Lu, Lu, Lu, McEwen, Mills, Mitchell, Molloy, Montcouquiol, Murdoch, Murdoch, Murdoch, N. D.E. Greene, Narimatsu, Neumann, O'Leary, O'leary, Okano, P. Stanier, Park, Parker, Parle-McDermott, Parle-McDermott, Qian, Relton, Relton, Scott, Shang, Shaw, Shields, Smithells, Stamm, Stamm, Steegers-Theunissen, Stegmann, Strutt, Strutt, Stumpf, Swanson, Swanson, Ting, Toepoel, Trembath, van der Linden, van der Linden, van der Linden, van der Linden, van der Put, van Straaten, Vanaerts, vandenBerg, Vieira, Volcik, Wallingford, Wang, Watanabe, Wilding, Wilson, Wu, Zhang, Zhu, Zhu, Zhu, Zhu, Zhu, Zohn   +131 more
core   +2 more sources

CoMFA and CoMSIA Analyses of Pneumocystis carinii Dihydrofolate Reductase, Toxoplasma gondii Dihydrofolate Reductase, and Rat Liver Dihydrofolate Reductase [PDF]

Journal of Medicinal Chemistry, 2005
In a continuing effort to develop potent and selective dihydrofolate reductase (DHFR) inhibitors against opportunistic pathogens, we developed three-dimensional quantitative structure-activity relationship (3D QSAR) models for the inhibitory activity against Pneumocystis carinii (pc) DHFR, Toxoplasma gondii (tg) DHFR, and rat liver DHFR, using a data ...
Aleem, Gangjee, Xin, Lin
openaire   +2 more sources

Increased Dynamic Effects in a Catalytically Compromised Variant of Escherichia coli Dihydrofolate Reductase

Journal of the American Chemical Society, 2013
Isotopic substitution (15N, 13C, 2H) of a catalytically compromised variant of Escherichia coli dihydrofolate reductase, EcDHFR-N23PP/S148A, has been used to investigate the effect of these mutations on catalysis.
J. Ruiz-Pernía, Louis Y. P. Luk, Rafael García-Meseguer, S. Martí, E. Loveridge, I. Tuñón, V. Moliner, R. Allemann   +7 more
semanticscholar   +1 more source

Erythrocyte Membrane Protein 3 (EMAP3) Is Exposed on the Surface of the Plasmodium berghei Infected Red Blood Cell

Molecular Microbiology, EarlyView.
Erythrocyte membrane protein 3 (EMAP3) is a novel Plasmodium berghei protein that is trafficked to the outer membrane surface of the infected red blood cell (iRBC). EMAP3 is not critical for parasite growth or sequestration but offers a new scaffold for displaying Plasmodium falciparum proteins on iRBCs.
Sophia Raine C. Hernandez, Ravish Rashpa, Thorey K. Jonsdottir, Martina S. Paoletta, Josy ter Beek, María Rayón Díaz, Jelte M. M. Krol, Severine Chevalley‐Maurel, Takahiro Ishizaki, Ronnie P.‐A. Berntsson, Chris J. Janse, Blandine Franke‐Fayard, Mathieu Brochet, Ellen S. C. Bushell   +13 more
wiley   +1 more source

Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance [PDF]

, 2004
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Atzori, C, Benfield, T, Crothers, KA, Haung, L, Helweg-Larsen, J, Miller, R, Rabodonirina, M   +6 more
core   +2 more sources

Exploring the Potential and Evaluating Hydrocarbon Degradation by Novel Antarctic Dietzia and Pusillimonas Isolates From a Pristine Environment

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
The Antarctic Dietzia and Pusillimonas isolates were tested for bioremediation applications. Genomic analyses revealed the potential to degrade complex organic compounds, potential virulence factors and resistance genes. Physiological assays showed a wide range of adaptation to abiotic factors and sensitivity to different groups of antibiotics ...
Tomasz Krucoń, Julia Karbowska, Wiktoria Pietrowicz, Robert Stasiuk, Łukasz Drewniak   +4 more
wiley   +1 more source