Results 81 to 90 of about 48,162 (258)

Effectiveness and safety of methotrexate in the treatment of mycosis fungoides: Real‐world data from a multicentre study

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 8, Page 1442-1448, August 2025.
Methotrexate (MTX) has been a longstanding therapeutic option for mycosis fungoides (MF); however, data on its real‐world effectiveness remain limited. This study aimed to assess real‐world outcomes of oral MTX in the treatment of MF. Data from five referral centres for cutaneous lymphoma in Greece were retrospectively reviewed with the baseline‐ and ...
Vasiliki Nikolaou, Evdoxia Panou, Antonios Tsimpidakis, Ioannis‐Alexios Koumprentziotis, Aikaterini Patsatsi, Marina Siakantaris, Sabine‐Elke Kruger‐Krasagakis, Leonidas Marinos, Elisavet Georgiou, Kyriaki Lampadaki, Aliki Velissari, Athina‐Ioanna Daponte, Aikaterini Doxastaki, Stella Kaliampou, Aristeidis Vaiopoulos, Iliana Konstandinou, Marios Koumourtzis, Eleftheria Lakiotaki, Vassiliki Pappa, Athanasios Tsamaldoupis, Alexander Stratigos, Evangelia Papadavid   +21 more
wiley   +1 more source

Therapeutic Efficacy of Sulfadoxine-Pyrimethamine and Prevalence of Resistance Markers in Tanzania Prior to Revision of Malaria Treatment Policy: Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Mutations in Monitoring in Vivo Resistance. [PDF]

, 2004
Prior to the 2001 malarial treatment policy change in Tanzania, we conducted trials to assess the efficacy of sulfadoxine-pyrimethamine (SP) and the usefulness of molecular markers in monitoring resistance.
Abdulla, Salim, Beck, Hans-Peter, Kataraihya, Johannes, Lemnge, Martha, Malisa, Allen, Mshinda, Hassan, Mugittu, Kefas, Mwita, Alex, Ndejembi, Modesta, Nkya, Watoky, Premji, Zulfikar   +10 more
core   +1 more source

Is Intralesional Methotrexate an Effective Alternative to Intralesional Triamcinolone in Alopecia Areata? Findings From a Randomized Controlled Trial

Journal of Cosmetic Dermatology, Volume 24, Issue 8, August 2025.
ABSTRACT Background Alopecia areata (AA) is an autoimmune condition resulting in hair loss, sometimes just in small patches but occasionally across larger areas like the entire scalp. For localized AA, treatments often involve injecting corticosteroids, such as triamcinolone acetonide (TrA), directly into the affected areas.
Narges Ghandi, Atiyeh Rashidi, Fatemeh Saberi, Robabeh Abedini, Nasim Tootoonchi, Hanie Babaie   +5 more
wiley   +1 more source

Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]

, 2015
Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core   +2 more sources

PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid

ChemBioChem, Volume 26, Issue 13, July 11, 2025.
Cell‐penetrating peptide (CPP)‐conjugated folic acid mediates efficient internalization of folic acid that is independent of the presence of proton‐coupled folate transporter (PCFT) on the intestinal cells. CPP‐conjugated folic acid demonstrates superior cellular uptake at all studied pH and in the presence of PCFT inhibitors and shows enhanced ...
Vineet Kumar Mishra, Rheal Towner, Juan Carlos Rodriguez‐Lecompte, Marya Ahmed   +3 more
wiley   +1 more source

Effect of Dimerization on Dihydrofolate Reductase Catalysis

Biochemistry, 2013
Dihydrofolate reductase (DHFR) from the hyperthermophile Thermotoga maritima (TmDHFR) forms a very stable homodimer, while DHFRs from other organisms are monomers. We investigated the effect of dimerization on DHFR catalysis by preparing a dimeric variant, Xet-3, of DHFR from Escherichia coli (EcDHFR).
E. Joel Loveridge, Rudolf Konrad Allemann, Louis Y. P. Luk, Jiannan Guo   +3 more
openaire   +6 more sources

On the relationship between thermal stability and catalytic power of enzymes [PDF]

, 2007
The  possible  relationship  between  the  thermal  stability  and  the  catalytic  power  of  enzymes  is  of   great  current  interest.  In  particular,  it  has  been  suggested  that  thermophilic  or  hyperthermophilic   (Tm)   enzymes   have ...
Liu, Hanbin, Messer, Benjamin, Roca, Maite, Warshel, Arieh   +3 more
core   +1 more source

High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics

Advanced Science, Volume 12, Issue 28, July 24, 2025.
The systematic tiling of essential genes’ mRNA here presented, proposes a valuable tool for the identification of novel PNA sequences with antibiotic potential. The high‐throughput synthetic set up opens the door to investigating thousands of sequences in an economic way and ultimately identifies potent antisense oligonucleotides while also giving room
Giorgia Danti, Linda Popella, Jörg Vogel, Hans M. Maric   +3 more
wiley   +1 more source

Tetrahydrobiopterin Uptake in Supplemental Administration: Elevation of Tissue Tetrahydrobiopterin in Mice Following Uptake of the Exogenously Oxidized Product 7,8-Dihydrobiopterin and Subsequent Reduction by an Anti-folate-Sensitive Process

Journal of Pharmacological Sciences, 2004
In order to increase the tissue level of tetrahydrobiopterin (BH4), supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the effectiveness of 6RBH4 was compared with 7,8-dihydrobiopterin (7,8BH2) and sepiapterin by ...
Keiko Sawabe, Kazunori Osuke Wakasugi, Hiroyuki Hasegawa   +2 more
doaj  

Cell-Cycle-Dependent Pharmacology of Methotrexate in HL-60

Journal of Pharmacological Sciences, 2005
The role of the susceptibility of cells and the pharmacokinetics of MTX on the time-dependent change of methotrexate (MTX) pharmacologic action in HL-60 (human leukemia cell) was investigated from the viewpoints of the rhythm of DNA synthesis.
Atsushi Yamauchi, Takanobu Ichimiya, Kouichi Inoue, Yukie Taguchi, Naoya Matsunaga, Satoru Koyanagi, Tatsuo Fukagawa, Hironori Aramaki, Shun Higuchi, Shigehiro Ohdo   +9 more
doaj