Results 91 to 100 of about 148,764 (203)

Successful use of uridine triacetate (Vistogard) three weeks after capecitabine in a patient with homozygous dihydropyrimidine dehydrogenase mutation: A case report and review of the literature

, 2017
5-fluorouracil and capecitabine are chemotherapeutic agents commonly used to treat solid malignancies. Increased susceptibility to 5-fluorouracil or capecitabine, caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, or other genetic
Yi-Kong Keung, David Yu, Mira Zurayk, Eddie HL Hu   +3 more
core   +1 more source

Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

Acta Pharmaceutica Sinica B, 2016
The expression of phase-I drug metabolizing enzymes in liver changes dramatically during postnatal liver maturation. Farnesoid X receptor (FXR) is critical for bile acid and lipid homeostasis in liver.
Lai Peng, Stephanie Piekos, Grace L. Guo, Xiao-bo Zhong   +3 more
doaj   +1 more source

Diagnosis of dihydropyrimidine dehydrogenase deficiency in a neonate with thymine-uraciluria

, 2003
Dihydropyrimidine dehydrogenase deficiency is an inborn error of pyrimidine metabolism characterised by thymine-uraciluria, convulsive disorders and developmental delay in paediatric patients, and an increased risk of toxicity from 5-fluorouracil ...
Shek, CC, Lam, CW, Chan, AYW, Au, KM, Lai, CK, Yuen, YP   +5 more
core  

Identification and tissue-specific expression of a NADH-dependent activity of dihydropyrimidine dehydrogenase in man

, 1996
Homogenates of human liver and human fibroblasts were able to convert thymine into dihydrothymine in the presence of NADH whereas almost no NADH-dependent activity could be detected in human lymphocytes.
van Kuilenburg, A. B., van Lenthe, H., van Gennip, A. H.   +2 more
core  

Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11[beta]-hydroxysteroid dehydrogenase 1 [PDF]

, 2008
Intracellular glucocorticoid reactivation is catalyzed by 11[beta]-hydroxysteroid dehydrogenase 1 (11[beta]-HSD1), which functions predominantly as a reductase in cells expressing hexose-6-phosphate dehydrogenase (H6PDH).
Alex Odermatt, Nashev, L. G., Chandsawangbhuwana, C., Lyubomir G. Nashev, Balazs, Z., Michael E. Baker, Baker, M. E., Odermatt, A., Charlie Chandsawangbhuwana, Zoltán Balázs   +9 more
core  

5-Fluorouracil Neurotoxicity in a Patient With Normal Dihydropyrimidine Dehydrogenase Activity. [PDF]

Cureus, 2023
Natarajan U, Onyechi A, Ohemeng-Dapaah J.   +2 more
europepmc   +1 more source

Prognostic relevance of thymidine phosphorylase-, dihydropyrimidine dehydrogenase- and thymidylate synthase-expression for nodal-negative colorectal carcinomas.

, 2009
In dieser retrospektiven Studie wurde an einem Kollektiv nodal-negativer colorectaler Carcinome die prognostischen Bedeutung von Thymidylat Synthase, Thymidin Phosphorylase und Dihydropyrimidin Dehydrogenase untersucht.
Schreglmann, Joachim Paul
core  

Partial protein binding of uracil and thymine affects accurate dihydropyrimidine dehydrogenase (DPD) phenotyping [PDF]

Fluorouracil is among the most used antimetabolite drugs for the chemotherapeutic treatment of various types of gastrointestinal malignancies. Dihydropyrimidine dehydrogenase (DPYD) genotyping prior to fluorouracil treatment is considered standard ...
Deenen, Maarten J., Deenen, M.J., van den Wildenberg, Sebastian A.H.; id_orcid, Dongen, J.L.J. van, Streng, A.S., Wildenberg, S.A.H. van den, Scharnhorst, V., Brunsveld, L., Scharnhorst, Volkher, Broeren, Maarten A.C., van de Kerkhof, Daan, Genet, S.A.A.M., Broeren, M.A.C., Genet, Sylvia A.A.M., Streng, Alexander S., Kerkhof, D. van de, van Dongen, Joost L.J., Brunsveld, Luc; id_orcid   +17 more
core   +1 more source

Hypogeusia and hyposmia with topical 5-fluorouracil treatment

JAAD Case Reports, 2020
Auston Gillis, BS, Lindsay Eminger, MD
doaj   +1 more source

Mutational spectrum of dihydropyrimidine dehydrogenase gene (DPYD) in the Tunisian population.

, 2007
Dihydropyrimidine dehydrogenase enzyme (DPD) deficiency is a pharmacogenetic syndrome leading to severe side-effects in patients receiving therapies containing the anticancer drug 5-fluorouracil (5-FU).
Ben Fredj, R;Gross, E;Chouchen, L;B'Chir, F;Ben Ahmed, S;Neubauer, S;Kiechle, M;Saguem, S
core   +1 more source