Results 101 to 110 of about 148,764 (203)

Impact of renal impairment on dihydropyrimidine dehydrogenase (DPD) phenotyping. [PDF]

ESMO Open, 2023
Royer B, Launay M, Ciccolini J, Derain L, Parant F, Thomas F, Guitton J.   +6 more
europepmc   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.

, 2018
The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to guide dosing of fluoropyrimidines (5-fluorouracil and capecitabine ...
Schellens, Jan H M, Swen, Jesse J, McLeod, Howard L, Caudle, Kelly E, Klein, Teri E, Schwab, Matthias, Offer, Steven M, Barbarino, Julia, Amstutz, Ursula, Henricks, Linda M, Diasio, Robert B   +10 more
core   +1 more source

The prognostic and therapeutic significance of biological molecular markers in human anorectal carcinomas treated with 5'fluorouracil chemoradiation. [PDF]

, 2005
Advances in tumour biology have led to studies of new biological markers, which may predict treatment response and clinical outcome independently of standard clinicopathological variables.
Mawdsley, S.K.V.
core  

Facile one-pot three-component synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thiones under ultrasonic irradiation

, 2019
We developed a facile one-pot procedure for the synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-thione under ultrasonic irradiation. The method is based on a three components reaction of aldehydes, ketones, and thiourea under basic conditions ...
Heba A. Hassan (7200470), Gamal El-Din A. Abuo-Rahma (7200473), Shymaa A. Abbass (7200464), Gamal A. I. Moustafa (7200467)   +3 more
core   +1 more source

Gastrointestinal Cancers with Consideration of DPD and UGT1A1 Plasma Levels: Chemotherapy-Related Toxicity

Life
Unpredictable, dose-limiting toxicity remains a challenge in cancer treatment. We evaluated dihydropyrimidine dehydrogenase (DPD) and UDP-glucuronosyltransferase 1A1 (UGT1A1) plasma levels in the context of chemotherapy-induced toxicity and disease ...
Velko Minchev, Hristo Tsankov, Bozil Robev, Martin Takov, Stefan Federchev, Kalina Kamenova, Lozan Todorov, Liliya Atanasova, Nadya Hristova-Avakumova, Rumen Nikolov, Pavlina Gateva, Vanyo Mitev   +11 more
doaj   +1 more source

The Evaluation of Dihydropyrimidine Dehydrogenase Enzyme Level in the Serum of Colorectal Cancer Iraqi Males on Fluoropyrimidine-Based Chemotherapy (Capecitabine). [PDF]

Cureus, 2023
Challoob MA, Mohammed NS.
europepmc   +1 more source

Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese

Dihydropyrimidine dehydrogenase (DPD) is the enzyme catalyzing the first step of pyrimidine metabolism. To date, genetic polymorphisms of pyrimidine-synthesizing enzymes have been reported to be associated with the risk of malignant lymphoma or colon ...
Hamajima, Nobuyuki, Kagami, Yoshitoyo, Yamamura, Yoshitaka, Shinoda, Masayuki, Iwata, Hiroji, Suyama, Motokazu, Hishida, Asahi, Hatooka, Shunzo, Mitsudomi, Tetsuya, Yamamoto, Kazuhito, Tamakoshi, Akiko, Ogura, Michinori, Tajima, Kazuo, Kato, Tomoyuki, Naito, Mariko, Tanaka, Daisuke, Matsuo, Keitaro   +16 more
core  

A pilot study using immunohistochemical staining to characterize dihydropyrimidine dehydrogenase expression in keratinocyte neoplasms. [PDF]

JAAD Int, 2023
Ikediobi O, Sui JY, Kellogg C, Mares AR, Takashima S, Bertini JD, Daniels B, Hinds B, Sun BK.   +8 more
europepmc   +1 more source

Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine-induced toxicity in an Asian population. [PDF]

Cancer Med, 2023
Kanai M, Kawaguchi T, Kotaka M, Manaka D, Hasegawa J, Takagane A, Munemoto Y, Kato T, Eto T, Touyama T, Matsui T, Shinozaki K, Matsumoto S, Mizushima T, Mori M, Sakamoto J, Ohtsu A, Yoshino T, Saji S, Matsuda F.   +19 more
europepmc   +1 more source

Dihydropyrimidine Dehydrogenase Deficiency [PDF]

, 2020
openaire   +1 more source