Results 141 to 150 of about 148,764 (203)

Assessment of dihydropyrimidine dehydrogenase dimer formation in human liver samples

Dihydropyrimidine dehydrogenase deficiency is a rare inheritable genetic disorder that increases the risk of severe to life-threatening toxicity following treatment of the anticancer drug 5-fluorouracil. Pre-screening patients with a panel of variants in
Machado, Ashton Jacob
core  

Real-World Impact of an In-House Dihydropyrimidine Dehydrogenase (<i>DPYD</i>) Genotype Test on Fluoropyrimidine Dosing, Toxicities, and Hospitalizations at a Multisite Cancer Center. [PDF]

JCO Precis Oncol
Nguyen DG, Morris SA, Hamilton A, Kwange SO, Steuerwald N, Symanowski J, Moore DC, Hanson S, Mroz K, Lopes KE, Larck C, Musselwhite L, Kadakia KC, Kadakia KC, Koya B, Chai S, Osei-Boateng K, Kalapurakal S, Swift K, Hwang J, Patel JN.   +20 more
europepmc   +1 more source

Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis. [PDF]

Br J Cancer
Le Teuff G, Cozic N, Boyer JC, Boige V, Diasio RB, Taieb J, Meulendijks D, Palles C, Schwab M, Deenen M, Largiadèr CR, Marinaki A, Jennings BA, Wettergren Y, Di Paolo A, Gross E, Budai B, Ackland SP, van Kuilenburg ABP, McLeod HL, Milano G, Thomas F, Loriot MA, Kerr D, Schellens JHM, Laurent-Puig P, Shi Q, Pignon JP, Etienne-Grimaldi MC, FUSAFE collaborative group.   +29 more
europepmc   +1 more source

Studies on Bacterial Dihydropyrimidine Dehydrogenases

Studies on Bacterial Dihydropyrimidine Dehydrogenases
openaire   +1 more source

Subcellular Localization of Dihydropyrimidine Dehydrogenase

Biological Chemistry, 1997
Although dihydropyrimidine dehydrogenase (DPD) has been purified and characterized from liver tissues of various mammals conflicting data exist on its subcellular localization. To determine the localization of DPD we prepared crude subcellular fractions of a rat liver homogenate by means of differential centrifugation.
van Kuilenburg, A. B., van Lenthe, H., Wanders, R. J., van Gennip, A. H.   +3 more
openaire   +6 more sources

Dihydropyrimidine dehydrogenase deficiency and acute neurological presentation

Journal of Inherited Metabolic Disease, 2003
AbstractDihydropyrimidine dehydrogenase (DPD) deficiency has been linked to 5‐fluorouracil toxicity, but patients may present a wide clinical spectrum. We describe a 1‐year‐old Tunisian girl with a dramatic onset of neurological symptoms suggesting the possible triggering role of environmental factors.
FIUMARA, Agata, VAN KUILEBURG ABP, CARUSO U, NUCIFORA C, MARZULLO E, BARONE, RITA MARIA ELISA, MELI C, VAN GENNIP H.   +7 more
openaire   +4 more sources

Head imaging abnormalities in dihydropyrimidine dehydrogenase deficiency

Journal of Inherited Metabolic Disease, 2004
AbstractSummary: Dihydropyrimidine dehydrogenase (DPD) deficiency is a rare autosomal recessive disorder of pyrimidine metabolism. Patients may present with a wide range of neurological symptoms during the first years of life. Head imaging abnormalities have been reported only rarely and include diffuse cerebral atrophy and white‐matter hyperintensity.
Enns, G. M., Barkovich, A. J., van Kuilenburg, A. B. P., Manning, M., Sanger, T., Witt, D. R., van Gennip, A. H.   +6 more
openaire   +4 more sources

Dihydropyrimidine Dehydrogenase Gene as a Major Predictor of Severe 5-Fluorouracil Toxicity

Pharmacogenomics, 2011
The importance of polymorphisms in the dihydropyrimidine dehydrogenase (DPD) gene (DPYD) for the prediction of severe toxicity in 5-fluorouracil (5-FU) based chemotherapy has been controversially debated. As a key enzyme in the catabolism of 5-FU, DPD is
Carlo Largiadèr, Ursula Amstutz
exaly   +2 more sources