Results 31 to 40 of about 15,827 (239)

Distinction of Drug-Induced Liver Injury From Autoimmune Hepatitis in Patients With Acute Liver Injury: Proposal of a Combination of Diagnostic Scores

Gastro Hep Advances, 2023
Background and Aims: Acute liver injury (ALI) due to autoimmune hepatitis (AIH) can be treated by immunosuppression. In contrast, idiosyncratic drug-induced liver injury (DILI) had a poor prognosis.
Keisuke Kakisaka, Nobuaki Nakayama, Kotaro Kumagai, Takuro Hisanaga, Takayuki Kondo, Toru Setsu, Shunsuke Sato, Yohei Kooka, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Hidekatsu Kuroda, Akio Miyasaka, Ryuzo Abe, Taka-aki Nakada, Yoshihiro Ikura, Kenichi Harada, Takuya Genda, Shuji Terai, Naoya Kato, Taro Takami, Akio Ido, Satoshi Mochida, Takayuki Matsumoto, Atsushi Tanaka   +24 more
doaj   +1 more source

Lessons Learnt Delivering a Novel Infectious Diseases National Training Programme to Timor-Leste’s Primary Care Workforce

Annals of Global Health
Background and Objectives: Timor-Leste is a lower-middle-income country in Southeast Asia. To control the significant local threat from infectious diseases, it is imperative to strengthen the knowledge and practice capabilities of the primary care ...
Robert Hammond, Antonito Hornay Cabral, Jeremy Beckett, Xhian Meng Quah, Natarajan Rajaraman, Sanjay Mathew, Amrutha Gopalakrishnan, Mariano Pereira, Manuel Natercio Noronha, Bernardo Pinto, João de Jesus Arcanjo, Celia Gusmao dos Santos, Telma Joana Corte-Real de Oliveira, Ingrid Bucens, Charlotte Hall   +14 more
doaj   +1 more source

Exploratory Study of Autoantibody Profiling in Drug‐Induced Liver Injury with an Autoimmune Phenotype

Hepatology Communications, 2020
Drug‐induced liver injury (DILI) sometimes presents with an autoimmune hepatitis‐like phenotype (AI‐DILI), and it is challenging to distinguish it from de novo autoimmune hepatitis (AIH).
Craig Lammert, Chengsong Zhu, Yun Lian, Indu Raman, George Eckert, Quan‐Zhen Li, Naga Chalasani   +6 more
doaj   +1 more source

Management of drug-induced liver injury in people with HIV treated for tuberculosis: 2024 update

Southern African Journal of HIV Medicine
No abstract available.
Tom Boyles, Rebecca H. Berhanu, Neliswa Gogela, Hannah Gunter, Tamsin Lovelock, Ndiviwe Mphothulo, Arifa Parker, Helena Rabie, Lauren Richards, Phumla Sinxadi, Camilla Wattrus, Mahomed-Yunus Moosa   +11 more
doaj   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Investigating Mitochondrial Viscosity in Ferroptosis‐Mediated Drug‐Induced Liver Injury using a Double‐Targeted Strategy

Advanced Science, EarlyView.
Utilizing a mitochondrial double‐targeted strategy, a novel near‐infrared fluorescent probe (FTZ‐2) is established for monitoring viscosity variations in ferroptosis‐mediated drug‐induced liver injury. In summary, this work provided a practical strategy for the early diagnosis and evaluation of liver injury.
Yongqing Zhou, Yan Wang, Bing Huang, Hosoowi Lee, Mei Yan, Juyoung Yoon   +5 more
wiley   +1 more source

The Incidence and Risk Factor Analysis of Drug Induced Liver Injury (Dili) in a Surabaya Hospital

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2018
The research has been conducted on the incident and analysis of risk factors drug liver injury (DILI) in a Surabaya Hospital. The aim of this study was to determine the incident of DILI, know which drugs cause DILI, and see the association of risk ...
Sherly Tandi Arrang, Widyati Widyati
doaj   +1 more source

Bismuth subcitrate, metronidazole and tetracycline – a rare cause of drug-induced liver injury

European Journal of Case Reports in Internal Medicine, 2023
Drug-induced liver injury (DILI) is a liver condition caused by any drug or toxic substance. The spectrum of DILI manifestations can range from asymptomatic elevation of liver enzymes to acute liver failure.
Carina Silva, Susana Merim, Rita Sevivas, João Mota, Alexandra Leitão   +4 more
doaj   +1 more source

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2

Advanced Science, EarlyView.
Domestication of Tartary buckwheat is selected for a salt tolerance mechanism involving the magnesium transporter FtMGT2. Its expression is controlled by the FtAGL16‐FtMYB15L module, which is stabilized under salt stress through a competitive interaction that blocks its degradation by the E3 ligase FtBRG1, ultimately boosting Na⁺ efflux and plant ...
Xiang Lu, Yuqi He, Wenfeng Weng, Zebin Liu, Yuanfen Gao, Yaliang Shi, Wei Li, Dili Lai, Mengyu Zhao, Rintu Jha, Hui Zhao, Guangsheng Li, Chaonan Guan, Shuai Shao, Jingjun Ruan, Sun Hee Woo, Yinan Ouyang, Muriel Quinet, Milen I. Georgiev, Alisdair R. Fernie, Congcong Hou, Kaixuan Zhang, Xu Liu, Meiliang Zhou   +23 more
wiley   +1 more source

Kur'an'da Benzetmelerin Dili

Journal of Turkish Studies, 2018
Bu makale, yüce Allah’ın Kur’ân-ı Kerîm’de dinî emirleri, olayları ve ilgili ortamlarda yer alan insanların tutum ve davranışlarını anlatırken yer verdiği benzetmelerin ifade ettiği hakikatler üzerinde duracaktır. Kur’an’da dinî emirler, olaylar ve davranış biçimleri üzerinden ifade edilen hakikatlerin anlaşılmasında benzetmelerin anlama katkısı, dil ...
openaire   +3 more sources