Results 71 to 80 of about 100,813 (283)

Kur'an'da Benzetmelerin Dili

Journal of Turkish Studies, 2018
Bu makale, yüce Allah’ın Kur’ân-ı Kerîm’de dinî emirleri, olayları ve ilgili ortamlarda yer alan insanların tutum ve davranışlarını anlatırken yer verdiği benzetmelerin ifade ettiği hakikatler üzerinde duracaktır. Kur’an’da dinî emirler, olaylar ve davranış biçimleri üzerinden ifade edilen hakikatlerin anlaşılmasında benzetmelerin anlama katkısı, dil ...
openaire   +4 more sources

In Vitro Assessment of Drug‐Induced Liver Injury Using Three‐Dimensional Cultured HepaSH Cells Derived From Chimeric Mouse Model With Humanized Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Drug‐induced liver injury (DILI) is a serious adverse event and a common cause of postmarketing drug withdrawal. Despite nonclinical assessments of DILI risk, which are predominantly conducted in experimental animals, DILI remains a frequent adverse event, highlighting the need to improve nonclinical assessments.
Xingming Liu, Yuichiro Higuchi, Yuta Sakamoto, Shota Yanagida, Shotaro Uehara, Hiroshi Suemizu, Yasunari Kanda, Hiroyuki Kawagishi   +7 more
wiley   +1 more source

Antibiotic-Associated Drug-Induced Liver Injury in Critically Ill Children: A Prospective Observational Study

Безопасность и риск фармакотерапии
INTRODUCTION. Drug-induced liver injury (DILI) is associated, among other things, with the use of antibiotics. Children with DILI are at risk of acute liver failure and even death. However, the literature on the subject provides little information on the 
A. V. Vlasova, Yu. F. Shubina, D. A. Sychev   +2 more
doaj   +1 more source

Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

Frontiers in Pharmacology, 2020
Drug-induced liver injury (DILI) is one of the major reasons for termination of drug development. Due to the importance of predicting DILI in early phases of drug development, diverse in silico models have been developed to filter out DILI-causing ...
Hyun Kil Shin, Myung-Gyun Kang, Daeui Park, Daeui Park, Tamina Park, Tamina Park, Seokjoo Yoon, Seokjoo Yoon   +7 more
doaj   +1 more source

Drug‐induced liver injury associated with selective androgen receptor modulators in an adolescent patient

JPGN Reports, EarlyView.
ABSTRACT Selective androgenic receptor modulators (SARMs) have similar properties to anabolic steroids but bind to androgen receptors in a tissue‐specific manner. Studies have investigated the benefits of SARMs in promoting bone and muscle growth while limiting the adverse effects of androgenic stimulation of other organs.
David J. Katibian, Laura E. Bauman, Katayoon Shayan, D. Brent Polk   +3 more
wiley   +1 more source

Pharmacogenetic Testing as a Tool to Prevent Isoniazid-Induced Hepatotoxicity in Pulmonary Tuberculosis Therapy: A Case Report

Безопасность и риск фармакотерапии
INTRODUCTION. Hepatotoxicity is the leading cause of isoniazid discontinuation, significantly reducing the efficacy of antituberculosis therapy, increasing the risk of disease relapse, and contributing to secondary drug resistance in Mycobacterium ...
N. M. Krasnova, E. A. Emelyanova, A. A. Egorova, E. S. Prokopyev, A. I. Vengerovskii, D. A. Sychev   +5 more
doaj   +1 more source

"Sılası Yitik" Bir Münzevi Ziya Osman Saba

Mukaddime, 2017
Beyhan Kanter tarafından kaleme alınan “Sılası Yitik” Bir Münzevi Ziya Osman Saba” adlı eser, Edebiyat Ortamı Yayınlarından çıkmıştır. Eser, “Sunuş”, “Hayatı” , “Eserleri” ve “Sonuç” bölümlerinden oluşur.
Şakire Balıkçı
doaj   +1 more source

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man [PDF]

, 2016
The current test systems employed by pharmaceutical industry are poorly predictive for drug-induced liver injury (DILI). The ‘MIP-DILI’ project addresses this situation by the development of innovative preclinical test systems which are both mechanism ...
Dragovic, Sanja, Gerets, Helga H, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Juhila, Satu, Park, B Kevin, Snoeys, Jan, Vermeulen, Nico PE, Weaver, Richard J   +8 more
core   +1 more source

Discovery of Potential GPRC5D Inhibitors through Virtual Screening and Molecular Dynamics Simulations

ChemistryOpen, EarlyView.
A systematic computational workflow integrates Protein–Ligand Affinity prediction NETwork (PLANET), a GPU‐accelerated version of AutoDock Vina (Vina‐GPU), molecular mechanics/generalized born surface area (MM/GBSA), absorption distribution metabolism excretion toxicity prediction (admetSAR 3.0), molecular dynamics (MD), and absolute binding free energy
Xi Chen, Xinle Yang, Roufen Chen, Lei Xu, Xiaowu Dong, Zhen Cai   +5 more
wiley   +1 more source

KARAY YAZI DİLİ

Littera Turca Journal of Turkish Language and Literature, 2015
M.S. 8. yuzyilda Musevilik inancinin bir mezhebi olarak ortaya cikan Karailik, zamanla bu toplulugun adi olmustur. Karay olarak adlandirilan bu toplulugun buyuk cogunlugu Hazar bakiyesi Turklerden olusmus ve gun gectikce de topluluk tamamen Turklesmistir. Karay Turkleri, inanclarina bagli olarak Ibrani alfabesini kullanmaya baslamislardir.
openaire   +3 more sources