Results 71 to 80 of about 105,621 (227)

Pharmacogenetic Testing as a Tool to Prevent Isoniazid-Induced Hepatotoxicity in Pulmonary Tuberculosis Therapy: A Case Report

Безопасность и риск фармакотерапии
INTRODUCTION. Hepatotoxicity is the leading cause of isoniazid discontinuation, significantly reducing the efficacy of antituberculosis therapy, increasing the risk of disease relapse, and contributing to secondary drug resistance in Mycobacterium ...
N. M. Krasnova, E. A. Emelyanova, A. A. Egorova, E. S. Prokopyev, A. I. Vengerovskii, D. A. Sychev   +5 more
doaj   +1 more source

Hepatic macrophages in drug-induced liver injury

Liver Research, 2019
Drug-induced liver injury (DILI) is a major public health concern. Intrinsic DILI, for example, acetaminophen overdose accounts for half of acute liver failure in the United States.
Zhao Shan, Cynthia Ju
doaj   +1 more source

Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]

, 2010
This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique, De Bus, Liesbet, Depuydt, Pieter, Libbrecht, Louis, NOLLET, JOKE, Van Vlierberghe, Hans, Vandekerckhove, Linos, Vogelaers, Dirk   +7 more
core   +1 more source

Chemical Profiling and Biological Activity of Copaiba Oil‐Resin Samples and Development of HPLC‐DAD Method for the Analysis of β‐Caryophyllene

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT The Copaifera species are traditionally used for their anti‐inflammatory, antiseptic and healing properties. The objective of this study was to compare the chromatographic profiles of seven samples of copaiba oil‐resin with respect to chromatographic and physicochemical properties and to evaluate their biological activities.
Gabriel de A. P. Graça, Cláudia G. Silva, Denise de O. Scoaris, Juliana Rodrigues de Vasconcelos, André Santos Alkimim, Vanessa C. F. Mosqueira, Luciana S. Salomon, Pietra Piotto Marcellini, Isabelle Renata Martins da Silva, Janete S. C. Santos, Andreia Fonseca Silva, Carolina P. S. Moreira, Júlio C. D. Lopes, Vera L. de Almeida   +13 more
wiley   +1 more source

The Influence of Regional Government and Community Participation on the Development of Spiritual Tourism in Pante Makasar, Timor-Leste

International Journal of Home Economics, Hospitality and Allied Research
This study examines the role of government and community participation in the development of spiritual tourism in Pante Makassar, Oe-Cusse Municipality, Timor-Leste.
Cevat Tosun, Jacinto Colo, Helio Brites da Silva   +2 more
doaj   +1 more source

Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

Frontiers in Pharmacology, 2020
Drug-induced liver injury (DILI) is one of the major reasons for termination of drug development. Due to the importance of predicting DILI in early phases of drug development, diverse in silico models have been developed to filter out DILI-causing ...
Hyun Kil Shin, Myung-Gyun Kang, Daeui Park, Daeui Park, Tamina Park, Tamina Park, Seokjoo Yoon, Seokjoo Yoon   +7 more
doaj   +1 more source

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1016-1024, April 2026.
Fezolinetant is a first‐in‐class, selective, non‐hormonal, neurokinin 3 receptor antagonist that is approved for the treatment of moderate to severe vasomotor symptoms due to menopause. In a phase 2b clinical study (n = 352), nine study participants experienced elevations in serum transaminases exceeding three times the upper limit of normal.
Jace C. Nielsen, Jeffrey L. Woodhead, Brett A. Howell, Lisl K. M. Shoda, Dolly A. Parasrampuria, Jiayin Huang, Megumi Iwai, Faith D. Ottery, Xuegong Wang, Marci English, Kentaro Miyazaki, Paul B. Watkins   +11 more
wiley   +1 more source

Üniversitelerdeki Türk Dili Derslerinin Dünü, Bugünü, Yarını (Sorunlar-Çözüm Önerileri) Çalıştayı

Skad, 2023
Bu yazı Sakarya Üniversitesi Rektörlük-Türk Dili Bölümü tarafından 26 Eylül 2023 tarihinde yapılan "Üniversitelerdeki Türk Dili derslerinin Dünü, Bugünü, Yarını (Sorunlar-Çözüm Önerileri)" adlı çalıştayı konu almaktadır.
Hürdünya Şahan, Özlem Düzlü
doaj  

The "empty shell" approach: the setup process of international administrations in Timor-Leste and Kosovo, its consequences and lessons [PDF]

, 2011
State-building under the aegis of international administrations has faced various hurdles and obstacles in Kosovo and Timor-Leste — failures that came to full light in March 2004 in Kosovo and in May 2006 in Timor-Leste.
Lemay-Hebert, Nicolas
core   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

ChemistryOpen, Volume 15, Issue 4, April 2026.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz, Rubel Hasan, Mst Muslima Khatun, Mokammel Hossain Tito, Md Shadin, Ranjit Chakma, Mohammed Asiri, Faisal H. Altemani, Abdullah H. Altemani, Md Shimul Bhuia, Muhammad Torequl Islam   +10 more
wiley   +1 more source