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Formulation of Sustained-Release Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules

Pharmaceutical Development and Technology, 2008
Semisolid matrix capsule formulations of verapamil HCl and diltiazem HCl prepared by hot-melt capsule filling are an especially appealing and simple way to make sustained-release formulations. Semisolid matrices of Gelucire 50/13 and stearic acid combination eroded and disintegrated at various rates, depending on the combination of waxes, and drug ...
Chien N, Nguyen   +2 more
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Liposomal diltiazem HCl as ocular drug delivery system for glaucoma

Drug Development and Industrial Pharmacy, 2013
In this study, unilamellar liposomal vesicles of diltiazem HCl (DH) were prepared using either reversed phase evaporation (REV) or proliposome methods. Soya phosphatidylcholine (SPC) was used for preparing the liposomes, and the vesicles were rigidified using cholesterol (Chol) or cetyl alcohol (CA) in different molarities.
Mahmoud, Mokhtar Ibrahim   +2 more
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Chronotherapy of Cardiac Diseases using Diltiazem HCl-A Review

Research Journal of Pharmacy and Technology, 2015
Hypertension is associated with increased cardio and cerebrovascular morbidity and mortality; antihypertensive drugs have been shown to reduce the risk of adverse cardio and cerebrovascular events. These events tend to be more common during the morning hours, a time when both normo and hypertensives show a circadian peak in blood pressure (BP ...
V. Kamalakkannan   +3 more
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Validation of manufacturing process of Diltiazem HCl tablets by NIR spectrophotometry (NIRS)

Journal of Pharmaceutical and Biomedical Analysis, 2007
The goal of this study was to apply the Process Analytical Technology FDA's initiative in pharmaceutical tablets manufacturing. Near Infrared Spectrophotometry (NIRS) was used as a non-destructive, very fast technique requiring no sample preparation. Direct compression powder blends containing Diltiazem HCl as a model drug were pressed into tablets for
Bodson, Cédric   +5 more
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New colorimetric methods for the determination of trazodone HCl, famotidine, and diltiazem HCl in their pharmaceutical dosage forms

Analytical and Bioanalytical Chemistry, 2003
Two sensitive and simple spectrophotometric methods are developed for the determination of trazodone HCl, famotidine, and diltiazem HCl in pure and pharmaceutical preparations. The methods are based on the oxidation of the cited drugs with iron(III) in acidic medium.
Magda M, Ayad   +3 more
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