Results 61 to 70 of about 4,456 (181)
Clinical Pharmacology &Therapeutics, Volume 116, Issue 2, Page 448-459, August 2024.The global rise in polypharmacy has increased both the necessity and complexity of drug–drug interaction (DDI) assessments, given the growing potential for interactions involving more than two drugs. Leveraging large‐scale healthcare claims data, we piloted a semi‐automated, high‐throughput case‐crossover‐based approach for drug–drug–drug interaction ...
Emily K. Acton +7 more
wiley +1 more source
Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials [PDF]
, 2016 The antihypertensive effect of magnesium (Mg) supplementation remains controversial. We aimed to quantify the effect of oral Mg supplementation on blood pressure (BP) by synthesizing available evidence from randomized, double-blind, placebo-controlled ...
Del Gobbo, Liana C. +6 more
core +1 more source
Environmental Toxicology and Chemistry, Volume 43, Issue 8, Page 1894-1902, August 2024.Abstract Though bioaccumulation of pharmaceuticals by aquatic organisms continues to receive scientific attention, the internal disposition of these contaminants among different tissue compartments of fish species has been infrequently investigated, particularly among fish at different trophic positions. We tested a human to fish biological read‐across
Jaylen L. Sims +8 more
wiley +1 more source
The impact of fish oil fatty-acids on post-prandial vascular reactivity. [PDF]
, 2014 Progressive loss of vascular reactivity and increased vascular tone with age are being increasingly recognised as significant cardiovascular disease (CVD) risk factors.
Mcmanus, Sean
core
Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study [PDF]
, 2017 Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C-4 ...
Edraki, N. +7 more
core +1 more source
Clinical Pharmacology in Drug Development, Volume 13, Issue 4, Page 367-379, April 2024.Abstract Etripamil, a fast‐acting nondihydropyridine L‐type calcium channel blocker, is under investigation for potential self‐administration for the acute treatment of supraventricular tachyarrhythmias in a medically unsupervised setting. We report detailed pharmacokinetics and pharmacodynamics of intranasally administered etripamil in healthy adults ...
James E. Ip +5 more
wiley +1 more source
Optimization and Characterization of Fenugreek Seed Polymer Nanoparticles Loaded with Diltiazem HCl Nanoparticles by Desolvation Method [PDF]
, 2019 The main aim of the present investigation is to optimize and evaluate the fenugreek seed polymer nanoparticles using Diltiazem HCl as a model drug because Diltiazem HCl has short half-life.
Akki, Rajesh +2 more
core +2 more sources
Effect of solvent on retarding the release of diltiazem HCl from Polyox-based liquisolid tablets
Journal of Pharmacy and Pharmacology, 2016 Abstract Objectives The aim of this work was to investigate the use of liquisolid technique to sustain the release of a model highly soluble drug, diltiazem HCl, from liquisolid matrices containing Polyox, a recently proposed matrix-forming hydrophilic polymer as an alternative to hypromellose.
Kaialy, Waseem +3 more
openaire +4 more sources
Journal of Medical Virology, Volume 96, Issue 4, April 2024.Abstract Hepatitis B virus (HBV) infection poses a significant burden on global public health. Unfortunately, current treatments cannot fully alleviate this burden as they have limited effect on the transcriptional activity of the tenacious covalently closed circular DNA (cccDNA) responsible for viral persistence.
Yu Zhang +9 more
wiley +1 more source
Pleiotropic Effects of Calcium Channel Blockers [PDF]
, 2012 Clinical trials have reported reduced cardiovascular events with certain antihypertensive agents at a rate that could not be predicted by changes in brachial arterial pressure alone.
Mason, R. Preston
core +2 more sources