Results 1 to 10 of about 5,287 (189)

Antimicrobial activities of Diltiazem Hydrochloride: drug repurposing approach [PDF]

PeerJ
Background The growing concern of antibiotic-resistant microbial strains worldwide has prompted the need for alternative methods to combat microbial resistance.
Omar K. Alduaij, Rageh K. Hussein, Sharif Abu Alrub, Sabry A. H. Zidan   +3 more
doaj   +5 more sources

Controlled Release Technologies for Diltiazem Hydrochloride: A Comprehensive Review of Solid Dosage Innovations [PDF]

Pharmaceutics
Introduction: Diltiazem hydrochloride (DH) is a calcium channel blocker used in the treatment of hypertension, angina pectoris, and arrhythmias. Its short half-life and frequent dosing requirements limit patient adherence and cause plasma concentration ...
Estefanía Troches-Mafla, Constain H. Salamanca, Yhors Ciro   +2 more
doaj   +2 more sources

Stability study of common vasoactive drugs diluted in five types of solutions [PDF]

Frontiers in Pharmacology
BackgroundVasoactive drugs are widely used during the perioperative period. Different vasoactive drugs have specific recommended solutions for dilution as stated in their instructions, but non-recommended solutions are sometimes used in clinical practice.
Han Yang, Bingbing Xiang, Deiying Gong, Guoyan Zhao, Wensheng Zhang, Wensheng Zhang   +5 more
doaj   +2 more sources

Validated gradient stability indicating HPLC method for determining Diltiazem Hydrochloride and related substances in bulk drug and novel tablet formulation [PDF]

Journal of Pharmaceutical Analysis, 2012
A stability-indicating liquid chromatographic method has been developed and validated for the determination of Diltiazem Hydrochloride (DTZ) together with its six related substances (Diltiazem sulphoxide, Imp-A, Imp-B, Imp-D, Imp-E, and Imp-F) in a ...
Vivekanand A. Chatpalliwar, Pawan K. Porwal, Neeraj Upmanyu   +2 more
doaj   +2 more sources

Diltiazem Hydrochloride Protects Against Myocardial Ischemia/Reperfusion Injury in a BNIP3L/NIX-Mediated Mitophagy Manner [PDF]

Journal of Inflammation Research
Xing Zhou,1,* Quan Lu,2,* Qiu Wang,2,* Wenxin Chu,2 Jianhao Huang,2 Jinming Yu,2 Yuechou Nong,2 Wensheng Lu2,* 1Pharmacy Department, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region ...
Zhou X, Lu Q, Wang Q, Chu W, Huang J, Yu J, Nong Y, Lu W   +7 more
doaj   +2 more sources

Design and development of controlled porosity osmotic tablet of diltiazem hydrochloride

Journal of Advanced Pharmaceutical Technology & Research, 2012
The present work aims towards the design and development of extended release formulation of freely water-soluble drug diltiazem hydrochloride (DLTZ) based on osmotic technology by using controlled porosity approach.
Sadhana R Shahi, Nityanand S Zadbuke, Bhushan Gulecha, Shantanu S Shivanikar, Shivram B Shinde   +4 more
doaj   +3 more sources

Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride

Journal of Advanced Pharmaceutical Technology & Research, 2012
Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action.
Afifa Bathool, D V Gowda, Mohammed S Khan, Ayaz Ahmed, S L Vasudha, K Rohitash   +5 more
doaj   +2 more sources

Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2013
The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not
Xi-Qing Yan, Zhi-Gang Chen, Rong-Liang Wang, Jun Yang, Fang Ai, Yan-Juan Pan, Pei-Yong Qiu, Da-Xin Wang   +7 more
doaj   +5 more sources

Employing intrinsic fluorone-dye fluorescence in a quenching-based (“on-off”) strategy for diltiazem determination in tablets and capsules [PDF]

BMC Chemistry
A novel green spectrofluorometric method was developed for the quantification of diltiazem hydrochloride (DLZ), a benzothiazepine-class calcium channel blocker with vasodilatory properties.
Ahmed A. Abu-hassan
doaj   +2 more sources

Development and evaluation of diltiazem hydrochloride controlled-release pellets by fluid bed coating process

Journal of Advanced Pharmaceutical Technology & Research, 2013
The aim of the present study was to develop controlled-release pellets of diltiazem HCl with ethyl cellulose and hydroxylpropyl methylcellulose phthalate as the release rate retarding polymers by fluid bed coating technique.
Mikkilineni Bhanu Prasad, Suryadevara Vidyadhara, Reddyvalam Lankapalli C Sasidhar, Talamanchi Balakrishna, Pavuluri Trilochani   +4 more
doaj   +2 more sources