Results 41 to 50 of about 5,306 (202)

In situ monitoring of powder blending by non-invasive Raman spectrometry with wide area illumination [PDF]

, 2013
A 785 nm diode laser and probe with a 6 mm spot size were used to obtain spectra of stationary powders and powders mixing at 50 rpm in a high shear convective blender.
Allan, Pamela, Andrews, John, Bellamy, Luke J., Dallin, Paul, Littlejohn, David, Nordon, Alison   +5 more
core   +1 more source

Diltiazem hydrochloride: New technologies and evolution of diltiazem [PDF]

Clinical Cardiology, 2009
Graded extended-release diltiazem (CARDIZEM® LA) (GRD) is a new formulation of diltiazem engineered to provide more precise blood pressure control than traditional antihypertensive agents. Unlike other diltiazem once-daily formulations, CARDIZEM® LA is a tablet formulation. Its pharmacokinetic profile differs from that of CARDIZEM® CD, another extended-
openaire   +1 more source

Niacin-induced clotting factor synthesis deficiency with coagulopathy [PDF]

, 1992
Although coagulopathy is a well-known complication of severe niacin- induced hepatotoxic reaction, it is not found in patients with minimal aminotransferase level elevations.
Dearing, Brian D., Genton, Edward, Lavie, Carl J., Lohmann, Thomas P.   +3 more
core   +1 more source

Case Report: Oxaliplatin-Induced Third-Degree Atrioventricular Block: First Discovery of an Important Side-Effect

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe adverse effects of anticancer therapy in patients with malignancies and cardiovascular diseases are complicated. Oxaliplatin is one of the most commonly used chemotherapy drugs for gastric and colorectal cancers, and oxaliplatin-induced ...
Xi Chen, Hui Wang, Zijin Zhang, Yan Xu, Xuanqi An, Xin Ai, Lin Li   +6 more
doaj   +1 more source

Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion [PDF]

, 2015
YesWe present hot melt extrusion (HME) for the design of floating multiparticulates. Metoprolol succinate was selected as the model drug. Our foremost objective was to optimize the components Eudragit® RS PO, polyethylene oxide (PEO) and hydroxypropyl ...
Devarajan, P.V., Malode, V.N., Paradkar, Anant R.   +2 more
core   +1 more source

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Pediatric antiarrhythmics and toxicity: A clinical review. [PDF]

J Am Coll Emerg Physicians Open
Abstract Antiarrhythmic medications are fundamental in the acute and chronic management of pediatric arrhythmias. Particularly in the pediatric patient population, associated antiarrhythmic toxicities represent important potential adverse effects. Emergency medicine clinicians must be skilled in the detection, workup, and management of antiarrhythmic ...
Geanacopoulos AT, Zielonka B, Fox MT, Kerr S, Chambers KD, Przybylski R, Burns MM.   +6 more
europepmc   +2 more sources

Improved crystal structure solution from powder diffraction data by the use of conformational information [PDF]

, 2017
The effect of introducing conformational information to the DASH implementation of crystal structure determination from powder diffraction data is investigated using 51 crystal structures, with the aim of allowing increasingly complex crystal structures ...
Adrian C. Williams, Allen, Bauer, Bekö, Borea, Bortolotti, Boultif, Bruno, Bruno, Burley, Burley, Bushmarinov, Carpy, Chernyshev, Chernyshev, Cole, David, David, DiMaio, Dinnebier, Donaldson, Dorokhov, Elena A. Kabova, Fernandes, Fernandes, Fernandes, Florence, Florence, Florence, Freer, Gadret, Griffin, Groom, Helmholdt, Ivashevskaya, Jason C. Cole, Johnston, Kennedy, Kenneth Shankland, Kojicprodic, Lefebvre, Llinàs, Maccaroni, Macrae, Majumder, Middleton, Nishibori, Noguchi, Nowell, Oliver Korb, Rukiah, Scapin, Shankland, Shin, Sorrenti, Streek, Yatsenko   +56 more
core   +1 more source

Anogenital Contact Dermatitis in Spain: A REIDAC Study of Patients Undergoing Patch Testing in 2019–2024

Contact Dermatitis, Volume 94, Issue 3, Page 272-285, March 2026.
Allergic contact dermatitis is very common in patients with anogenital lesions referred for patch testing in Spain. Key allergens include fragrances, preservatives and topical treatments like anaesthetics and steroids. Emerging sensitisers including benzisothiazolinone and sodium metabisulphite are also relevant.
Mercè Grau‐Pérez, Pedro Mercader‐García, Ana María Giménez‐Arnau, Tatiana Sanz‐Sánchez, Violeta Zaragoza Ninet, Susana Córdoba Guijarro, Francisco Javier Miquel Miquel, Juan Francisco Silvestre Salvador, Ricardo González‐Pérez, Inmaculada Ruíz González, Esther Serra Baldrich, José Manuel Carrascosa, Francisco Javier Ortiz de Frutos, Mercedes Rodríguez Serna, María Elena Gatica Ortega, Carmen Paredes Suárez, Francisco José Navarro Triviño, Pablo Chicharro, Marta Andreu, Araceli Sánchez Gilo, José Juan Pereyra Rodríguez, María Antonia Pastor Nieto, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua‐González, Mónica Munera‐Campos, Fátima Tous Romero, Miguel Ángel Descalzo, Leopoldo Borrego   +29 more
wiley   +1 more source

A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila [PDF]

, 2007
It has been shown that presenilin is involved in maintaining Ca(2+) homeostasis in neurons, including regulating (ER) Ca(2+) storage. From studies of primary cultures and cell lines, however, its role in stress-induced responses is still controversial ...
Fortini, M. E., Hong, Y., Lu, Y., Lv, Y., Wang, Y., Xie, Z., Ye, Y., Zhong, Y.   +7 more
core   +1 more source