Results 51 to 60 of about 5,306 (202)

Development and validation of a stability indicating HPLC method to determine diltiazem hydrochloride in tablets and compounded capsules

Brazilian Journal of Pharmaceutical Sciences, 2017
A stability indicating HPLC method to determine diltiazem hydrochloride (DTZ) in tablets and compounded capsules was developed and validated according to Brazilian and the International Conference on Harmonization (ICH) guidelines.
Mateus Araújo Castro e Souza, Carlos Eduardo de Oliveira Pereira, Fernando Henrique Andrade Nogueira, Gerson Antônio Pianetti   +3 more
doaj   +1 more source

Maternal Apocynin During Experimental Preeclampsia Prevents BBB Permeability and Increased Vascular Tone of Cerebral Arteries in Male but Not Female Rat Adult Offspring

Microcirculation, Volume 33, Issue 1, January 2026.
ABSTRACT Objective We examined if exposure to experimental preeclampsia (ePE) impacts vascular permeability and reactivity of posterior cerebral arteries (PCAs) in adult offspring, and if maternal antioxidant treatment prevents these effects in adult male and female offspring. Methods Offspring (F1) from rats with Normal pregnancy (NormPreg_F1), ePE_F1
Milena Esposito, Sarah M. Tremble, Marilyn J. Cipolla   +2 more
wiley   +1 more source

Aortic Stiffness in L-NAME Treated C57Bl/6 Mice Displays a Shift From Early Endothelial Dysfunction to Late-Term Vascular Smooth Muscle Cell Dysfunction

Frontiers in Physiology, 2022
Introduction and Aims: Endothelial dysfunction is recognized as a cardiovascular aging hallmark. Administration of nitric oxide synthase blocker N-Ω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) constitutes a well-known small animal model of ...
Sofie De Moudt, Jhana O. Hendrickx, Cédric Neutel, Dorien De Munck, Arthur Leloup, Guido R.Y. De Meyer, Wim Martinet, Paul Fransen   +7 more
doaj   +1 more source

Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1 [PDF]

, 2016
Among the dysfunctions and pathologies associated with sepsis, the underlying molecular mechanisms of sepsis-induced acute lung injury (ALI) are poorly understood.
Akhtar Shila, Hideaki Sakuramoto, Hizawa Nobuyuki, Inoue Yoshiaki, Jesmin Subrina, Kawano Satoru, Khatun Tanzila, Kiwamoto Takumi, Matsuishi Yujiro, Mizutani Taro, Mowa Chishimba Nathan, Shimojo Nobutake, Tsunoda Yoshiya, Zaedi Sohel, 下條 信威, 井上 貴昭, 松石 雄二朗, 檜澤 伸之, 水谷 太郎, 河野 了, 際本 拓未   +20 more
core   +1 more source

Prevalence and Duration of Potential Drug–Drug Interactions Among US Nursing Home Residents, 2018–2020

Journal of the American Geriatrics Society, Volume 73, Issue 12, Page 3766-3777, December 2025.
ABSTRACT Background Nursing home (NH) residents are at increased risk of drug–drug interactions (DDIs) due to multimorbidity and polypharmacy. While prior research suggests that many DDIs lead to adverse drug events in older adults, the extent of exposure to potentially clinically relevant DDIs among United States (US) NH residents is largely unknown ...
Laura A. Reich, Lori A. Daiello, Sarah D. Berry, Adam M. D'Amico, Douglas P. Kiel, Daniel A. Harris, Kaleen N. Hayes, Charles E. Leonard, Yu‐Chia (Sam) Hsu, Andrew R. Zullo   +9 more
wiley   +1 more source

Coronary arterial spasm detected by coronary computed tomography angiography and confirmed by intravascular ultrasound

Radiology Case Reports, 2018
A 40-year-old man was admitted to our hospital for chest pain after smoking. Coronary computed tomography angiography showed severe stenosis in the left anterior descending artery.
Masafumi Nakayama, MD, Masaharu Hirano, MD, Sonoka Goto, MD, Akifumi Watanabe, MD, Takashi Uchiyama, MD   +4 more
doaj   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, Volume 35, Issue 35, August 28, 2025.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Development of sustained-release floating tablets of diltiazem hydrochloride

Vietnam Journal of Science, Technology and Engineering
Diltiazem hydrochloride (DTZ), utilised for cardiovascular conditions, possesses a short half-life, necessitating frequent dosing. To enhance compliance, sustainedrelease (SR) floating tablets were developed using a Quality by Design (QbD) approach ...
Hung Pham Van, Tung Nguyen Thanh, Nhat Hoang Thi Anh, Hieu Bui Trung, Uyen Dinh Thi Thu, Duyen Nguyen Thi Thanh   +5 more
doaj   +3 more sources

Determination of Diltiazem Hydrochloride using Paperbased ECL sensor

Journal of Research in Pharmacy, 2022
In this study, a paper-based electrochemiluminescence (ECL) sensor was developed for the determinationof diltiazem hydrochloride (DTZ-HCl), which is a vasodilator of the calcium channel blocker. Herein, the ability of DTZto act as a co-reactant for Ru(bpy)32+ in the ECL system was utilized.
openaire   +4 more sources

Critical insights into analytical methodologies for lidocaine hydrochloride and diltiazem hydrochloride: a comparative review

Future Journal of Pharmaceutical Sciences
Background This study focuses on a fixed-dose combination of lidocaine hydrochloride and diltiazem hydrochloride for the treatment of anal fissures, where lidocaine acts as an anesthetic and diltiazem serves as a slow calcium channel blocker.
Shivani Patel, Archita Patel, Chandni Chandarana, Bhavesh Patel, Mehul Patel, Umang Shah, Swayamprakash Patel, Nilay Solanki, Drashti Shah, Ashish Patel   +9 more
doaj   +1 more source