Urea Transporter Inhibitor 25a Reduces Ascites in Cirrhotic Rats [PDF]
Biomedicines, 2023 Ascites is a typical symptom of liver cirrhosis that is caused by a variety of liver diseases. Ascites severely affects the life quality of patients and needs long-term treatment.
Yi Ying +9 more
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Effects of Isosakuranetin on Pharmacokinetic Changes of Tofacitinib in Rats with N-Dimethylnitrosamine-Induced Liver Cirrhosis [PDF]
Pharmaceutics, 2022 Tofacitinib, a Janus kinase 1 and 3 inhibitor, is used to treat rheumatoid arthritis. It is mainly metabolized by the cytochromes p450 (CYP) 3A1/2 and CYP2C11 in the liver.
Sung Hun Bae +5 more
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Granulocyte-macrophage colony-stimulating factor (GM-CSF) shows therapeutic effect on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. [PDF]
PLoS ONE, 2022 This study was undertaken to investigate the inhibitory effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on dimethylnitrosamine (DMN)-induced liver fibrosis in rats.
Mrigendra Bir Karmacharya +4 more
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Integrative Transcriptomic Analysis Reveals Upregulated Apoptotic Signaling in Wound-Healing Pathway in Rat Liver Fibrosis Models [PDF]
Antioxidants, 2023 Liver fibrosis, defined by the aberrant accumulation of extracellular matrix proteins in liver tissue due to chronic inflammation, represents a pressing global health issue.
Jihyun Kim +6 more
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Preclinical approaches to studying liver and kidney fibrosis: models and methodologies [PDF]
Frontiers in PharmacologyOrgan fibrosis, notably affecting the liver and kidneys, remains a major contributor to global morbidity. This review examines the pathophysiology, molecular mechanisms, and preclinical models used to study hepatic and renal fibrosis.
Abhilasha Tiwari +5 more
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Species-specific renal and liver responses during infection with food-borne trematodes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis. [PDF]
PLoS ONEThree food-borne trematodes-Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis-are closely related epidemiologically important species.
Oxana G Zaparina +5 more
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Retraction Note: Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats [PDF]
BMC Gastroenterology, 2022 Cheng Liu +7 more
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Research progress on detection methods of N-dimethylnitrosamine in foods
Zhongguo shipin weisheng zazhi, 2023 N-dimethylnitrosamine is one of the most toxic nitrosamine compounds and can be produced in the process of food processing or storage. The detection methods are various with tedious operation and low accuracy. QuEChERS pretreatment combined with GC/LC-MS
SHEN Xiangzhen +7 more
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THE PROTECTIVE EFFECT OF N-ACETYLCYSTEINE (NAC) AGAINST OXIDATIVE STRESS ENZYME AND LIPID PROFILE FOR TOXICITY MALE RATS BY DIMETHYLNITROSAMINE [PDF]
Basrah Journal of Veterinary Research, 2020 The present study is conduct to evaluated the deleterious effects ofadministration of dimethylnitrosamine (DMN) on the some oxidative stress and lipidprofile parameters of laboratory male rats (Rattus rattus), we used eighteen adult malerats randomly ...
Mohammed younis et al.,
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Drug Delivery, 2022 Cranberry extract (CBE) is a major source of the antioxidant polyphenolics but suffers from limited bioavailability. The goal of this research was to encapsulate the nutraceutical (CBE), into bile salt augmented liposomes (BSALs) as a promising oral ...
Sara M. Soliman +4 more
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