Results 121 to 130 of about 2,282 (176)

Dimethylnitrosamine Demethylase and the Mutagenicity of Dimethylnitrosamine

1984
Although the Ames Salmonella plate incorporation assay(1) is the most widely used method for screening chemicals for potential carcinogenicity, it is well known that many carcinogens are not detected in this test. Some of these “false negative” compounds, such as highly chlorinated organic carcinogens, are also difficult to detect in other mutagenicity
Michael J. Prival, Valerie D. Mitchell
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Hepatotoxicity of dimethylnitrosamine in cats and lizards

Toxicology Letters, 1981
The hepatotoxic effects of the oral administration of a single dose of 50 mg dimethylnitrosamine (DMN)/kg and daily doses of 5 mg and 1 mg/kg, respectively, to cats and lizards were studied by light microscopy. Centrilobular necrosis was the main alteration detected in the liver of cats as in other animal species studied. The lizards, however, appeared
Maduagwu, E. N., Anosa, Victor O.
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Dimethylnitrosamine in the Human Vaginal Vault

Nature, 1973
THE high frequency of cancer of the uterine cervix in southern Africans1 and the general epidemiological features of the disease2 suggest that chemical carcinogens might be found in infected discharge from the human cervix.
J S, Harington, J R, Nunn, L, Irwig
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Alkylation of messenger RNA by dimethylnitrosamine

Chemico-Biological Interactions, 1976
Rats were treated with radioactive dimethylnitrosamine or methyl methanesulphonate and the alkylation of various RNA fractions was determined 4 h later. It was found that after administration of dimethylnitrosamine, hepatic messenger RNA (isolated by binding to oligo(dT)-cellulose) and nuclear RNA were alkylated slightly, but significantly less than ...
A E, Pegg, A, Jackson
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Effects of Dimethylnitrosamine

1987
The possibility that chemicals found in the environment can suppress certain immune responses is one of the cornerstones of immunotoxicology. The nitrosamines represent an environmentally important group of compounds that includes dimethylnitrosamine (DMN, N-Nitrosodimethylamine).
A. E. Munson, M. P. Holsapple, S. S. Duke   +2 more
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Dimethylnitrosamine in Chinese marine salt fish

Food and Cosmetics Toxicology, 1973
Abstract Samples of marine salt fish from the markets in Hong Kong were analysed for N , N -dimethylnitrosamine (DMNA). Significant amounts of this compound, commonly in the 0·05-0·3 ppm range, were detected by gas chromatography and were confirmed in several samples by gas chromatography-mass spectrometry.
Y Y, Fong, W C, Chan
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Schwingungsspektren isotoper dimethylnitrosamine

Spectrochimica Acta Part A: Molecular Spectroscopy, 1971
Abstract Vibrational spectra of seven isotopic dimethylnitrosamines in different states of aggregation and solvents have been obtained. An assignment of the observed frequencies to the normal vibrations is given, which is based essentially on the isotopic frequency shifts.
P. Rademacher, W. Lüttke
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Repair synthesis and sedimentation analysis of DNA of human cells exposed to dimethylnitrosamine and activated dimethylnitrosamine

Biochemical and Biophysical Research Communications, 1973
Abstract The capacity of dimethylnitrosamine(DMN), and of DMN activated by a NADPH-fortified mouse liver microsomal preparation, to elicit DNA alterations in cultured human fibroblasts was examined. A maximum induction of DNA repair synthesis, estimated by unscheduled incorporation of tritiated thymidine, occurred following 60-minute incubation of ...
B A, Laishes, H F, Stich
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Regulation of dimethylnitrosamine metabolism by androgenic hormones

Environmental Mutagenesis, 1980
AbstractHormonal regulation of dimethylnitrosamine (DMN) metabolism by mouse kidney microsomes was investigated using an in vitro mutagenesis system that detects bioactive metabolites of this procarcinogen by measuring reverse mutation in Salmonella typhimurium his auxotrophs.
K, Bakshi, D, Brusick, L P, Bullock, C W, Bardin   +3 more
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Kinetics of the nitrosation of aminopyrine to give dimethylnitrosamine

Zeitschrift f�r Krebsforschung und Klinische Onkologie, 1974
The initial rate of nitrosation of aminopyrine (AP, Pyramidon) to give dimethyl nitrosamine (DMN) showed maxima at pH 2.0 and 3.1. At pH 2, initial rate was proportional to nitrite concentration squared down to 6 mM, below which it decreased rapidly.
S S, Mirvish, B, Gold, M, Eagen, S, Arnold   +3 more
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