Results 131 to 140 of about 2,282 (176)

Induction of microsomal dimethylnitrosamine demethylase by pyrazole

Biochemical Pharmacology, 1982
Pyrazole, a potent inhibitor of alcohol dehydrogenase, was found to be a potent inducer of the activity of low Km dimethylnitrosamine demethylase (DMN-d). One injection of pyrazole (200 mg/kg body wt) to weanling Wistar rats changed the microsomal DMN demethylase activity by 1.7, 1.9 and 2.5 times the control values at 6, 12 and 24 hr after the ...
R P, Evarts, E, Haliday, M, Negishi, L M, Hjelmeland   +3 more
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Pathology of dimethylnitrosamine poisoning in pekin ducklings

Toxicology and Applied Pharmacology, 1966
Summary Pekin ducklings were fed a purified diet containing dimethylnitrosamine at levels of 0.02% and 0.0175%. The level of 0.02% was acutely toxic, weight gains were significantly reduced, and feeding was discontinued after 3 weeks. Abdominal distention was observed in some ducks fed 0.0175% dimethylnitrosamine for 4 weeks. A nonhemorrhagic ascites
W W, Carlton, J E, Lord, L, Friedman
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Induction of nephroblastomas in the rat with dimethylnitrosamine

Zeitschrift f�r Krebsforschung, 1968
Highly anaplastic renal tumors (nephroblastoma type) have been induced regularly in rats fed dimethylnitrosamine. In the course of carcinogenesis, proliferative lesions — renal oval cell proliferation — have been commonly observed in the contralateral kidney.
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Investigations into the hepatic metabolism of dimethylnitrosamine in the rat

Life Sciences, 1975
Abstract In this paper we report the detection and identification of methanol as an intermediate formed during both the in vivo and the in vitro metabolism of dimethylnitrosamine (DMN) in the rat. Methanol was formed in both hepatic 10,000 g av.
B G, Lake, M J, Minski, J C, Phillips, S D, Gangolli, A G, Lloyd   +4 more
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Dimethylnitrosamine demethylase activity in Drosophila,melanogaster

Biochemical and Biophysical Research Communications, 1982
A dimethylnitrosamine (DMN) demethylase with levels of activity comparable to that in uninduced rat liver was demonstrated in both larval and adult forms of the Hikone-R strain of Drosophila. A microsomal enzyme, it has many properties of a cytochrome P-450-containing mixed-function oxidase.
L C, Waters, C E, Nix, J L, Epler
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Effect of ethanol on microsomal metabolism of dimethylnitrosamine

Journal of Cancer Research and Clinical Oncology, 1980
Rat liver microsomes were prepared from male and female controls and from animals pretreated for 3 weeks with ethanol, and incubated with dimethylnitrosamine (DMN) and an NADPH-regenerating system. The formation of formaldehyde and nitrite as well as the alkylation of microsomal protein were found to be greatly enhanced, especially in the low DMN ...
M, Schwarz, K E, Appel, D, Schrenk, W, Kunz   +3 more
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Suppression of dimethylnitrosamine mutagenicity by sodium nitrite

Mutation Research, 1974
Summary Doses of NaNO2 as low as 25 mg/kg were found to lower the frequency of observed mutants produced by dimethy1nitrosamine (DMN) in S. typhimurium G46 in the host-mediated assay. The degree of reduction of mutant frequency (MIT) was greatest when NaNO2 administration preceded DNIN treatment by 45 min.
D B, Couch, M A, Friedman
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Oxidative metabolism of dimethylnitrosamine: Correlation with toxicity

Journal of Toxicology and Environmental Health, 1978
The relationship between oxidative metabolism and acute toxicity of dimethylnitrosamine (DMN) was examined in neonatal and adult rats to take advantage of developmental changes in activity of the metabolizing enzymes. The objective was to determine the extent to which CO2 production from DMN is correlated with toxicity.
M, Ruchirawat, R C, Shank
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Metabolism of dimethylnitrosamine by amphibians and fish in vitro

Experientia, 1973
On a examine le metabolism de la (C14)-DMN par des coupes de foie de truite, de poisson rouge et de trois especes d'amphibiens, ainsi que l'excretion du cancerogene apres injection par voie intraperitoneale chez le triton et le poisson rouge. La relation entre le metabolisme et l'activite toxique et/ou cancerogene est discutee.
R, Montesano, A J, Ingram, P N, Magee
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N-Dimethylnitrosamine in Tobacco Smoke Condensate

Nature, 1972
THE possible presence of N-nitrosamines in cigarette smoke and/or condensate has been of interest for some years. Druckrey and Preussmann1 postulated that N-nitrosamines could be produced in burning tobacco, but the difficulty of measuring these compounds prevented the testing of this postulate.
J W, Rhoades, D E, Johnson
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