Experimental Basis for the High Oral Toxicity of Dinophysistoxin 1: A Comparative Study of DSP [PDF]
Toxins, 2014 Okadaic acid (OA) and its analogues, dinophysistoxin 1 (DTX1) and dinophysistoxin 2 (DTX2), are lipophilic and heat-stable marine toxins produced by dinoflagellates, which can accumulate in filter-feeding bivalves.
Diego A. Fernández +5 more
doaj +8 more sources
Specification of the Okadaic Acid Equivalent for Okadaic Acid, Dinophysistoxin-1, and Dinophysistoxin-2 Based on Protein Phosphatase 2A Inhibition and Cytotoxicity Assays Using Neuro 2A Cell Line [PDF]
Journal of Marine Science and Engineering, 2021 Diarrhetic shellfish poisoning (DSP) is a globally occurring disease threatening public health and trade. The causative toxins, okadaic acid (OA), dinophysistoxin-1 (DTX1), and dinophysistoxin-2 (DTX2) are collectively called OAs, and are quantified ...
Tsuyoshi Ikehara +2 more
doaj +3 more sources
Toxic Action Reevaluation of Okadaic Acid, Dinophysistoxin-1 and Dinophysistoxin-2: Toxicity Equivalency Factors Based on the Oral Toxicity Study [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Okadaic acid (OA) and the structurally related compounds dinophysistoxin-1 (DTX1) and dinophysistoxin-2 (DTX2) are marine phycotoxins that cause diarrheic shellfish poisoning (DSP) in humans due to ingestion of contaminated shellfish. In
Paula Abal +8 more
doaj +5 more sources
A Dinophysistoxin 2-like Okadaic Acid Isomer Present in Bivalves and Water Column: Temporal and Spatial Distribution in the Northwest Iberian Peninsula [PDF]
ToxinsA previously overlooked isomer of okadaic acid (OA), which is structurally related to dinophysistoxin-2 (DTX2), was identified in bivalves and water columns from the Northwest Iberian Peninsula.
Juan Blanco +5 more
doaj +3 more sources
Identification of 24-O-β-d-Glycosides and 7-Deoxy-Analogues of Okadaic Acid and Dinophysistoxin-1 and -2 in Extracts from Dinophysis Blooms, Dinophysis and Prorocentrum Cultures, and Shellfish in Europe, North America and Australasia [PDF]
Toxins, 2021 Two high-mass polar compounds were observed in aqueous side-fractions from the purification of okadaic acid (1) and dinophysistoxin-2 (2) from Dinophysis blooms in Spain and Norway.
Alistair L. Wilkins +12 more
doaj +2 more sources
Total Synthesis of Dinophysistoxin‐2 and 2‐ epi ‐Dinophysistoxin‐2 and Their PPase Inhibition [PDF]
Angewandte Chemie, 2011 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86962/1/ange_201101741_sm_miscellaneous_information.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/86962/2/7773_ftp ...
Yucheng Pang +9 more
core +7 more sources
A structural basis for the reduced toxicity of dinophysistoxin-2
Chemical Research in Toxicology, 2009 Okadaic acid (OA), dinophysistoxin-1 (DTX-1), and dinophysistoxin-2 (DTX-2) are algal toxins that can accumulate in shellfish and cause diarrhetic shellfish poisoning.
Cox, Neil R. +8 more
core +4 more sources
Toxins, 2015 For the first time the presence of dinophysistoxin-1 (DTX-1) in a culture of Prorocentrum foraminosum was revealed in cells and in the culture medium. The clone was isolated from coastal waters of the Sea of Japan and identified by molecular analyses of ...
Polina A. Kameneva +3 more
doaj +2 more sources
Integrated Multi-Omics Analysis Reveals Complex Cytotoxicity-Associated Molecular Response Patterns of Representative Toxins from Four Classes of Lipophilic Algal Toxins in Neuro-2a Cells [PDF]
ToxinsLipophilic marine toxins (LMTs) are important toxic risk factors in marine ecosystems and seafood safety, yet the comparative cytotoxicity-associated molecular responses of different LMT classes remain unclear.
Xueru Wei +5 more
doaj +2 more sources
Toxicon, 1999 Non-toxic scallops Patinopecten yessoensis were reared for 5 days with the toxic dinoflagellate Dinophysis fortii sampled from the sea. The total cell number ingested by five scallops during the feeding experiment was approximately 682 x 10(3). Okadaic acid (OA), dinophysistoxin-1 (DTX1) and esterified toxins of OA and DTX1 in D.
Toshiyuki Suzuki +2 more
core +3 more sources