Results 121 to 130 of about 4,332 (163)

Stability of Diosgenin

Journal of Pharmaceutical Sciences, 1968
The decomposition of 25α-Δ 5 -spirosten-3β-ol (diosgenin) has been studied by various physical techniques in the solid state, in contact with both 2 N hydrochloric acid and 2 N sodium carbonate solution, and in solution in both chloroform and benzene.
G, Blunden, C T, Rhodes
openaire   +2 more sources

Effect of diosgenin on cholesterol metabolism

Journal of Atherosclerosis Research, 1962
Summary In chickens fed a stock diet with 2 % cholesterol, the addition of 0.2–2.0 % diosgenin ( Δ 5 -22 ɛ -spirosten-3 β -ol) prevented the resulting hypercholesterolemia. Animals were followed up from 22 to 100 days and at the end of the experimental period, serum cholesterol values averaged about 110–180 mg% in control animals, 700–850 mg% in the ...
J, LAGUNA   +3 more
openaire   +2 more sources

Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells

European Journal of Pharmacology, 2020
(25R)-spirost-5-en-3β-ol, also known as diosgenin (DSG), exerts antiproliferative activity on diverse cell lines, induces apoptosis, and acts as a chemopreventative agent. However, the relationship between DSG glycosides and apoptotic, necrotic, and antiproliferative activity remains unclear.
José Misael Vicente, Hernández-Vázquez   +8 more
openaire   +2 more sources

Microbial modification of diosgenin and hecogenin

Journal of the Chemical Society, Perkin Transactions 1, 1973
On incubation with an unidentified bacterium diosgenin [(25R)-spirost-5-en-3β-ol](1) was converted into (25R)-9-oxode-AB-spirostane-8α-propionic acid (3). Incubation with Nocardia globerula produced the same oxo-acid (3) and also a small amount of its 1 7α-hydroxy-derivative.
R, Howe   +3 more
openaire   +2 more sources

Meiosis activating sterols derived from diosgenin

Bioorganic & Medicinal Chemistry Letters, 2002
Continuing research based on the meiosis activation properties of the endogenous sterol FF-MAS is reported. The synthesis and SAR of 16- and 26-substituted sterols are described, utilising diosgenin as starting material. Selected sterols were tested for their ability to induce oocyte maturation in hypoxanthine arrested mouse oocytes in vitro.
Anthony, Murray   +3 more
openaire   +2 more sources

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