Results 101 to 110 of about 55,716 (280)

Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

Nature Cell Biology, 2021
Lei-lei Chen, Carmen Morcelle, Zhou-Li Cheng, Xiufei Chen, Yan-ping Xu, Yajing Gao, Junbin Song, Zhijun Li, Matthew D. Smith, Miao Shi, Yezhang Zhu, Neng Zhou, Meng Cheng, Chenxi He, Kwei‐Yan Liu, Guo-xiong Lu, Lei Zhang, Cheng Zhang, Jinye Zhang, Yiping Sun, Tuan Qi, Yingying Lyu, Zhizhong Ren, Xiankui Tan, Jiayong Yin, F. Lan, Ying Liu, Hui Yang, Maoxiang Qian, C. Duan, X. Chang, Yufeng Zhou, Liguo Shen, A. Baldwin, K. Guan, Y. Xiong, D. Ye   +36 more
semanticscholar   +1 more source

Catalytic mechanism of cofactor-free dioxygenases and how they circumvent spin-forbidden oxygenation of their substrates.

Journal of the American Chemical Society, 2015
Dioxygenases catalyze a diverse range of biological reactions by incorporating molecular oxygen into organic substrates. Typically, they use transition metals or organic cofactors for catalysis.
Aitor Hernández‐Ortega, M. Quesne, S. Bui, D. Heyes, R. Steiner, N. Scrutton, S. D. de Visser   +6 more
semanticscholar   +1 more source

A nonradioactive restriction enzyme-mediated assay to detect DNA repair by Fe(II)/2-oxoglutarate-dependent dioxygenase [PDF]

, 2014
The Escherichia coli DNA repair enzyme AlkB belongs to the Fe(II)/2-oxoglutarate-dependent dioxygenase family. It removes methyl groups from 1-methyl adenine (1-meA) and 3-methyl cytosine (3-meC) lesions present in single-stranded DNA by oxidative ...
K, Naveena, Roy, Anindya, S, Gururaj
core   +1 more source

Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-β-lactamase Superfamily*

Journal of Biological Chemistry, 2015
Background: Persulfide dioxygenases (PDOs), which belong to the metallo-β-lactamase (MBL) enzyme superfamily, oxidize glutathione persulfide (GSSH). Results: Crystal structures and ITC data provide information on ligand binding by PDOs.
S. A. Sattler, Xia Wang, K. Lewis, P. J. DeHan, Chung-Min Park, Yufeng Xin, Honglei Liu, M. Xian, L. Xun, C. Kang   +9 more
semanticscholar   +1 more source

Plasmids and aromatic degradation in Sphingomonas for bioremediation : Aromatic ring cleavage genes in soil and rhizosphere [PDF]

, 2009
Microbial degradation pathways play a key role in the detoxification and the mineralization of polyaromatic hydrocarbons (PAHs), which are widespread pollutants in soil and constituents of petroleum hydrocarbons.
Sipilä, Timo
core  

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +3 more sources

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Background: Little is known about the impact of nutrients on cellular transcriptional responses, especially in face of environmental stressors such as oxygen deprivation.
Alvina G. Lai, Donall Forde, Wai Hoong Chang, Fang Yuan, Xiaodong Zhuang, Claudia Orbegozo Rubio, Chun-Xiao Song, Jane A. McKeating   +7 more
doaj   +1 more source

Isolation and characterization of two novel halotolerant Catechol 2, 3-dioxygenases from a halophilic bacterial consortium

Scientific Reports, 2015
Study of enzymes in halophiles will help to understand the mechanism of aromatic hydrocarbons degradation in saline environment. In this study, two novel catechol 2,3-dioxygenases (C23O1 and C23O2) were cloned and overexpressed from a halophilic ...
Guang Guo, Tingting Fang, Chongyang Wang, Yong Huang, Fang Tian, Qijia Cui, Hui Wang   +6 more
semanticscholar   +1 more source

1,N 6 -α-hydroxypropanoadenine, the acrolein adduct to adenine, is a substrate for AlkB dioxygenase [PDF]

, 2017
1,N6-α-hydroxypropanoadenine (HPA) is an exocyclic DNA adduct of acrolein – an environmental pollutant and endocellular oxidative stress product. Escherichia coli AlkB dioxygenase belongs to the superfamily of α-ketoglutarate (αKG)- and iron-dependent ...
Dylewska, Małgorzata, Kusmierek, Jaroslaw T., Maciejewska, Agnieszka M., Pilżys, Tomasz, Poznański, Jarosław   +4 more
core   +1 more source

Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression

Frontiers in Oncology, 2014
Ascorbate is a specific co-factor for a large family of enzymes known as the Fe- and 2-oxoglutarate-dependent dioxygenases. These enzymes are found throughout biology and catalyze the addition of a hydroxyl group to various substrates.
Caroline Kuiper, M. Vissers
semanticscholar   +1 more source