Results 111 to 120 of about 25,787 (305)
BMEMat, EarlyView.ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning +10 more
wiley +1 more source
A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machinery [PDF]
, 2008 Background: Several human pathologies, including neoplasia and ischemic cardiovascular diseases, course with an unbalance between oxygen supply and demand ( hypoxia).
Alcaide-German, ML +4 more
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Structure of the 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP. [PDF]
, 2014 The enzyme 2,4'-dihydroxyacetophenone dioxygenase (DAD) catalyses the conversion of 2,4'-dihydroxyacetophenone to 4-hydroxybenzoic acid and formic acid with the incorporation of molecular oxygen. Whilst the vast majority of dioxygenases cleave within the
Cooper, JB +7 more
core +1 more source
RORγt‐APCs: The New Masters of Oral Tolerance
Barrier Immunity, EarlyView.ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley +1 more source
Biodegradation of paracetamol by Amycolatopsis sp. Poz 14
BMC Research NotesObjective Paracetamol is widely used throughout the world and its high consumption has led to its detection in the environment as an emerging contaminant. In this work, the actinobacterium Amycolatopsis sp.
Janet Jan-Roblero +5 more
doaj +1 more source
The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures. [PDF]
, 2020 Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation.
Brown, Anthony P, Ji, Hong, Zhu, Tao
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European Journal of Inorganic Chemistry, EarlyView.The concept of scorpionate ligands has evolved significantly since the introduction of tris(pyrazolyl)borate. By integrating a biological supramolecular ligand scaffold with the classic scorpionate architecture, researchers have made notable strides in mimicking the active sites of nitrogenase and advancing homogeneous catalysis.
Austin Winfield Medley +1 more
wiley +1 more source
Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer
Clinical Epigenetics, 2018 Background 5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases.
Ding Peng +16 more
doaj +1 more source
Ring-hydroxylating dioxygenases involved in PAH biodegradation : structure, function, biodiversity [PDF]
, 2011 International audienceThe first step in the biodegradation of PAHs by aerobic bacteria is catalyzed by metalloenzymes known as ring-hydroxylating dioxygenases (RHDs). Because of the hydrophobic nature and chemical resistance of PAHs, their initial attack
Jouanneau, Yves +3 more
core +1 more source
European Journal of Inorganic Chemistry, EarlyView.The correlation between the structures of metal complexes immobilized in the mesopores of hydrophobically modified silicate supports was examined in relation to the catalytic activities toward C‐H oxidation. On the alkene oxidation with H2O2, the iron catalyst bearing bis(imidazolyl)methane ligand promotes allylic oxidation, whereas the mononuclear ...
Yuta Akizawa +8 more
wiley +1 more source