Results 121 to 130 of about 14,709 (260)

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

2-Hydroxyglutarate in onco-pathway: a metabolic driver of proto-oncogene activation. [PDF]

Front Oncol
Thamim M, Dhabal D, Balamurali MM, Thirumoorthy K.   +3 more
europepmc   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

How Does Tuning of the Primary Coordination Sphere Around Ferryl-Oxo Intermediates Affect Structure and Reactivity? Insights into Axial and Equatorial Ligand Field Effects. [PDF]

JACS Au
Mukherjee G, Panwar P, Sastri CV, Satpathy JK, de Visser SP.   +4 more
europepmc   +1 more source

Prebiotic aqueous reactions catalyzed by native nickel without hydrogen

The FEBS Journal, EarlyView.
Serpentinizing (H2‐producing) hydrothermal vents are candidate environments for metabolic origin. They generate highly reducing conditions that convert CO2 to formate and methane in abiotic reactions resembling reactions of the acetyl‐CoA pathway of CO2 fixation. They also contain natural catalysts. Native nickel (Ni0), like Fe0, Co0, and their alloys,
Carolina Garcia Garcia, Max Brabender, William F. Martin   +2 more
wiley   +1 more source

Structural and mechanistic basis of sulfolytic C-S bond cleavage by an Fe(ii)/α-ketoglutarate-dependent sulfoquinovose dioxygenase. [PDF]

Chem Sci
Lee M, Ho HNN, Maher MJ, Jameson GNL, Williams SJ.   +4 more
europepmc   +1 more source

Loss of DNA methylation is not associated with venetoclax–hypomethylating agents synergy in acute myeloid leukaemia cells

British Journal of Haematology, EarlyView.
Aida Selimović‐Pašić, Lisa Haglund, Maike Bensberg, Júlia Goldmann, Padraig D'arcy, Sandra Hellberg, Colm E. Nestor   +6 more
wiley   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Whole-genomic and transcriptomic analyses elucidate <i>p</i>-cresol and styrene degradation metabolism in <i>Rhodococcus opacus</i> 1CP. [PDF]

Appl Environ Microbiol
Kumaran S, Heine T, Gröning JAD, Schlömann M, Albersmeier A, Busche T, Kalinowski J, Rückert-Reed C, Schaffert L, Tischler D.   +9 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source