Results 151 to 160 of about 25,787 (305)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Structural and mechanistic basis of sulfolytic C-S bond cleavage by an Fe(ii)/α-ketoglutarate-dependent sulfoquinovose dioxygenase. [PDF]

Chem Sci
Lee M, Ho HNN, Maher MJ, Jameson GNL, Williams SJ.   +4 more
europepmc   +1 more source

Losartan Enhances Radiosensitivity by Reversing Immunosuppressive Tumor Microenvironment Induced by Radiotherapy in TNBC

Cancer Science, EarlyView.
Our study demonstrates that the angiotensin receptor blocker losartan enhances the efficacy of radiotherapy in triple‐negative breast cancer by reversing the immunosuppressive tumor microenvironment. Losartan reprograms tumor‐associated macrophages, inhibits myeloid‐derived suppressor cell function, and boosts CD8+ T‐cell activity.
Xu Wang, Cuiwei Liu, Zihan Xia, Ting Hu, Yuting Li, Dan Han, Yunjie Song, Yuxi Ma, Yanxia Zhao   +8 more
wiley   +1 more source

Whole-genomic and transcriptomic analyses elucidate <i>p</i>-cresol and styrene degradation metabolism in <i>Rhodococcus opacus</i> 1CP. [PDF]

Appl Environ Microbiol
Kumaran S, Heine T, Gröning JAD, Schlömann M, Albersmeier A, Busche T, Kalinowski J, Rückert-Reed C, Schaffert L, Tischler D.   +9 more
europepmc   +1 more source

Lactate‐Induced Liquid–Liquid Phase Separation of HIF‐1α Drives Myeloid Cell Polarization and Immune Evasion in Colorectal Cancer

Cell Proliferation, EarlyView.
Lactate‐Induced Liquid‐Liquid Phase Separation of HIF‐1α Drives Myeloid Cell Polarization and Immune Evasion in Colorectal Cancer.
Chenhao Fu, Xiang Chen, Haoyu Huang, Lipeng Zhang, Haonan Huang, Fan Jiang, Fayang Lei, Honglong Yu, Jibiao Liu, Houping Zhang, Kan Dai, Zhixiong Wu, Huizi Li, Xi‐jian Dai, Shengxun Mao   +14 more
wiley   +1 more source

Unlocking microbial potential: advances in omics and bioinformatics for aromatic hydrocarbon degradation. [PDF]

World J Microbiol Biotechnol
Vidal-Silva IM, Loza A, Gutierrez-Rios RM.   +2 more
europepmc   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, EarlyView.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Asphaltene biodegradation and transcriptome responses of hydrocarbon degradation genes in soil by a novel tolerant fungal consortium. [PDF]

Environ Sci Pollut Res Int
Barrera MS, Marín C, Cortés-Espinosa DV, Zafra G.   +3 more
europepmc   +1 more source

Genome sequence of the plant growth promoting endophytic yeast Rhodotorula graminis WP1. [PDF]

, 2015
Andrea eFirrincieli, Asaf eSalamov, Erika eLindquist, Igor V. Grigoriev, Jeremy eSchmutz, Jeremy eSchmutz, Neil David Fleck, Regina S. Redman, Robert eOtillar, Sharon Lafferty Doty, Zareen eKhan   +10 more
core   +3 more sources

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source