Results 101 to 110 of about 20,669 (341)

Occurrence of guanosine-5'-diphosphate-3'-diphosphate and adenosine-5'-triphosphate-3'-diphosphate in Streptomyces galilaeus.

Agricultural and Biological Chemistry, 1980
Synthetic activity and existence of ppGpp and pppApp in an anthracycline-producing strain Streptomyces galilaeus were determined by radioimmunoassay and 32P-labeling method during cultivation under both the antibiotic productive and non-productive conditions. The cellular ppGpp(pppGpp)-synthesizing activity was highest at the end of exponential growth,
Akihiro Yoshimoto, Yasutaro Hamagishi, Taiji Inui, Toshikazu Oki   +3 more
openaire   +3 more sources

Modulation of Phenol Oxidation in Cofacial Dyads [PDF]

, 2015
The presentation of two phenols on a xanthene backbone is akin to the tyrosine dyad (Y[subscript 730] and Y[subscript 731]) of ribonucleotide reductase. X-ray crystallography reveals that the two phenol moieties are cofacially disposed at 4.35 Å.
Halbach, Robert L., Huynh, Michael, Koo, Bon Jun, Nocera, Daniel G., Stubbe, JoAnne   +4 more
core   +3 more sources

Coulomb Interaction as the Source of Muscle Force [PDF]

arXiv, 2007
Myosin motor is the machine, which performs mechanical work in the course of adenosine triphosphate molecule hydrolysis and myosin head conformations accompanying this process. For displacement of individual fragments of large molecule relative to each other to arise and work to be performed, force must be born inside protein.
arxiv  

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei [PDF]

, 1992
Tissue-specific patterns of methylated deoxycytidine residues in the mammalian genome are preserved by postreplicative methylation of newly synthesized DNA. DNA methyltransferase (MTase) is here shown to associate with replication foci during S phase but
Alsner, Altschul, Ascoli, Beck, Bensch, Bestor, Bestor, Bestor, Bestor, Bestor, Brancolini, Bravo, Carmo-Fonseca, Carter, Cook, Czank, D'Andrea, Fox, Fu, Gauthier-Rouvière, Goldman, Gruenbaum, Hatton, Huang, Kaiser, Kambach, Kumar, Lasko, Lauster, Lawrence, Li, Li, Matthias, Meier, Mills, Morris, Nakamura, Nakayasu, Noguchi, O'Keefe, Ottiger, Peculis, Posfai, Roise, Sambrook, Saunders, Spector, Tomkinson, Tubo, Vissel, Wang, Weier   +51 more
core   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

A prebiotic basis for ATP as the universal energy currency

PLoS Biology, 2022
ATP is universally conserved as the principal energy currency in cells, driving metabolism through phosphorylation and condensation reactions. Such deep conservation suggests that ATP arose at an early stage of biochemical evolution. Yet purine synthesis
Silvana Pinna, Cäcilia Kunz, Aaron Halpern, Stuart A. Harrison, Sean F. Jordan, John Ward, Finn Werner, Nick Lane   +7 more
doaj  

Metabolic engineering of Escherichia coli for production of mixed isoprenoid alcohols and their derivatives

Biotechnology for Biofuels, 2018
Background Current petroleum-derived fuels such as gasoline (C5–C12) and diesel (C15–C22) are complex mixtures of hydrocarbons with different chain lengths and chemical structures.
Bakht Zada, Chonglong Wang, Ji-Bin Park, Seong-Hee Jeong, Ju-Eon Park, Hawaibam Birla Singh, Seon-Won Kim   +6 more
doaj   +1 more source

Получение дифосфатов МР2О7 (M = Nb, Ta, Re, Mo, W) в условиях высоких давлений и каталитическая активность систем Pt(Pd)/MP₂O₇ в реакции окисления водорода [PDF]

, 2012
Сообщается о получении в условиях термобарической обработки дифосфатов MP₂O₇ (M = W, Mo, Nb, Ta, Re) как исходных матриц для каталитических водородно-окисляющих систем Pt(Pd)/MP₂O₇.Повідомляється про отримання в умовах термобаричної обробки дифосфатів ...
Болдырева, О.Ю., Лесняк, В.В., Сафонова, В.В., Стратийчук, Д.А.   +3 more
core  

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

Angewandte Chemie International Edition, Accepted Article.
Pseudouridine‐5’‐triphosphate (ΨTP) and the N1‐methylated derivative (m1ΨTP) are critical monomer building blocks of the currently used mRNA vaccines, yet efficient methods of their synthesis from readily accessible substrates remain underdeveloped. We herein report notably atom‐economic and high‐yielding biocatalytic route toward ΨTP (83% yield) and ...
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source