Results 81 to 90 of about 5,927 (259)

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Optical detection of di- and triphosphate anions with mixed monolayer-protected gold nanoparticles containing zinc(II)–dipicolylamine complexes

Beilstein Journal of Organic Chemistry, 2020
Gold nanoparticles covered with a mixture of ligands of which one type contains solubilizing triethylene glycol residues and the other peripheral zinc(II)–dipicolylamine (DPA) complexes allowed the optical detection of hydrogenphosphate, diphosphate, and
Lena Reinke, Julia Bartl, Marcus Koch, Stefan Kubik   +3 more
doaj   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Biosynthese des vollständig gesättigten C16‐Homosesquiterpens Descartan durch Deprotonierung mit Cyclopropanierung

Angewandte Chemie, EarlyView.
Eine nicht‐kanonische C16‐Sesquiterpensynthase aus Morganella morganii produziert das ungewöhnliche Grundgerüst Descartan. Ihr Cyclisierungsmechanismus wurde mittels Isotopenmarkierungsexperimenten und DFT‐Berechnungen aufgeklärt. Gezielte Mutagenese veränderte die Enzymfunktion und führte zu alternativen Produkten, darunter Voltairen, dessen ...
Kexin Yang, Philip Troycke, Bernd Goldfuss, Michael Groll, Jeroen S. Dickschat   +4 more
wiley   +1 more source

The 8-MOP identification and isolation from the plant material and percutaneous permeation in the modified Flynn’s cell

Current Issues in Pharmacy and Medical Sciences
Xanthotoxin (8-methoxypsoralen, methoxsalen) is a natural furanocoumarin consisting of coumarin annulated with furan. It’s biosynthetic route in plants continues with the activation of dimethylallylpyrophosphate (DMAPP), produced via the mevalonate ...
Elwira Sieniawska, Joanna Fliszkiewicz, Katarzyna Borowska, Tomasz Baj, Zofia Ulz, Kazimierz Głowniak   +5 more
doaj  

Zirkuläre, Photogeschützte mRNA für Lichtinduzierte Aktivierung der Translation zu späten Zeitpunkten

Angewandte Chemie, EarlyView.
Eine klickbare, photogeschützte 5′‐Kappe (CyCliCap) zur Herstellung von zyklischer, Click‐Cap enthaltender mRNA (Cyclic Click Cap‐mRNA), die bis zur Bestrahlung beachtlich stabil und translational stumm ist, ermöglicht die Aktivierung der Translation in Zellen zu späten Zeitpunkten mittels Lichts. ZUSAMMENFASSUNG mRNA ist eine neue Impfstofftechnologie
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

A prebiotic basis for ATP as the universal energy currency

PLoS Biology, 2022
ATP is universally conserved as the principal energy currency in cells, driving metabolism through phosphorylation and condensation reactions. Such deep conservation suggests that ATP arose at an early stage of biochemical evolution. Yet purine synthesis
Silvana Pinna, Cäcilia Kunz, Aaron Halpern, Stuart A. Harrison, Sean F. Jordan, John Ward, Finn Werner, Nick Lane   +7 more
doaj  

Biosynthesis of the Fully Saturated C16 Homosesquiterpene Descartane Through Deprotonation With Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
A non‐canonical C16 sesquiterpene synthase from Morganella morganii produces the unusual scaffold descartane. Its cyclisation mechanism was rationalised by isotopic labelling experiments and DFT calculations. Site‐directed mutagenesis altered enzyme function, resulting in alternative products, including voltairene, which requires a different ...
Kexin Yang, Philip Troycke, Bernd Goldfuss, Michael Groll, Jeroen S. Dickschat   +4 more
wiley   +1 more source