Results 61 to 70 of about 7,026 (202)

The effect of phosphonylmethyl analogs of ribonucleoside 5'-diphosphates on (E. coli) polynucleotide phosphorylase catalyzed reactions

, 1987
Ribonucleoside 5'-O-phosphorylphosphonylmethyl ethers (I) are not substrates of Escherichia coli polynucleoside phosphorylase in the presence of either Mg2+- or Mn2+-ions.
Masahiko Nishizawa, Antonín Holý, Ivan Rosenberg, Ivan Votruba   +3 more
core   +1 more source

Synthesis of Isotopically Labelled Oligoprenyl Diphosphates and Their Application in Mechanistic Investigations of Terpene Cyclases

, 2014
A flexible, efficient and robust method for the synthesis of isotopically labelled oligoprenyl diphosphates was developed. The method makes use of just a few building blocks (acetone, triethyl phosphonoacetate, and ethyl acetoacetate) from which several ...
Patrick Rabe, Barra, Lena, Hoshino, Tsutomu, Jeroen S. Dickschat, Citron, Christian A., Lena Barra, Chiaki Nakano, Christian A. Citron, Tsutomu Hoshino, Rabe, Patrick, Dickschat, Jeroen S., Nakano, Chiaki   +11 more
core   +1 more source

Molecular Studies of the Protein Complexes Involving Cis-Prenyltransferase in Guayule (Parthenium argentatum), an Alternative Rubber-Producing Plant

Frontiers in Plant Science, 2019
Guayule (Parthenium argentatum) is a perennial shrub in the Asteraceae family and synthesizes a high quality, hypoallergenic cis-1,4-polyisoprene (or natural rubber; NR).
Adam M. Lakusta, Moonhyuk Kwon, Moonhyuk Kwon, Eun-Joo G. Kwon, Solomon Stonebloom, Henrik V. Scheller, Dae-Kyun Ro   +6 more
doaj   +1 more source

Stereoselective Chemical Synthesis of Sugar Nucleotides via Direct Displacement of Acylated Glycosyl Bromides

, 2016
The use of Leloir glycosyltransferases to prepare biologically relevant oligosaccharides and glycoconjugates requires access to sugar nucleoside diphosphates, which are notoriously difficult to efficiently synthesize and purify.
David L. Jakeman (1411447), Shannon C. Timmons (2421427)   +1 more
core   +1 more source

Antibacterial effects of commercially available phosphates on selected microorganisms

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2008
In the food industry, phosphates, polyphosphates and their salts are used, for example, as emul­si­fying agents in the production of processed cheese.
Leona Buňková, Pavel Pleva, František Buňka, Pavel Valášek, Stanislav Kráčmar   +4 more
doaj   +1 more source

Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase. [PDF]

PLoS ONE, 2008
Deoxynucleoside triphosphates (dNTPs) are the normal substrates for DNA synthesis catalyzed by polymerases such as HIV-1 reverse transcriptase (RT). However, substantial amounts of deoxynucleoside diphosphates (dNDPs) are also present in the cell. Use of
Scott J Garforth, Michael A Parniak, Vinayaka R Prasad   +2 more
doaj   +1 more source

5'-Phosphoramidates and 5'-diphosphates of 2'-O-allyl-β-D- arabinofuranosyl-uracil, -cytosine, and -adenine: Inhibition of ribonucleotide reductase

, 1999
Continuing our studies on ribonucleotide reductase (RNR) mechanism-based inhibitors, we have now prepd. the diphosphates (DP) of 2'-O-allyl-1-β-D-arabinofuranosyl-uracil and -cytosine and 2'-O-allyl-9-β-D-arabinofuranosyl-adenine and evaluated their ...
DURINI, Elisa, VERTUANI, Silvia, BALZARINI JAN, BARALDI, Pier Giovanni, KARLSSON ANNA, BUZZONI VALENTINA, THELANDER LARS, DE CLERCQ ERIK, MANFREDINI, Stefano, Balzarini, J, Durini, E, De, Clercq E, Karlsson, A,, Vertuani, S, Manfredini, S, Buzzoni, V, Baraldi, PG, Thelander, L, Lars Thelander, Stefano Manfredini, Erik De Clercq, Valentina Buzzoni, Pier Giovanni Baraldi, Jan Balzarini, Anna Karlsson, Silvia Vertuani, Elisa Durini   +26 more
core   +1 more source

Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl- arabinofuranosyl nucleosides

, 1999
The diphosphates of a series of 2'-O-allyl-1-beta-D-arabinofuranosyl derivatives, previously obtained by us, have been prepared and tested for their inhibitory activity in an in vitro assay using R1 and R2 subunits of the purified recombinant mouse ...
KARLSSON A., DE CLERCQ E., BARALDI, Pier Giovanni, DURINI E., BALZARINI J., THELANDER L., MANFREDINI, Stefano, BUZZONI V., Balzarini, J, Durini, E, De, Clercq E, Karlsson, A,, Manfredini, S, Buzzoni, V, Baraldi, PG, Thelander, L   +15 more
core   +1 more source

In vitro degradation of guanosine 5'-diphosphate, 3'-diphosphate. [PDF]

Proceedings of the National Academy of Sciences, 1977
The degradation of guanosine 5'-diphosphate,3'-diphosphate (ppGpp) by the "crude" ribosomal fraction of Escherichia coli CP78 (rel+, spoT+) was demonstrated and characterized. When the 3'-pyrophosphoryl group of ppGpp was hydrolyzed, the primary degradation product was 5'-GDP. Phosphorylation of ppGpp to guanosine 5'-triphosphate,3'-diphosphate (pppGpp)
openaire   +2 more sources

NM23-H1: a Metastasis-Associated Gene

Taiwanese Journal of Obstetrics & Gynecology, 2006
The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates.
Yi-Torng Tee, Gin-Den Chen, Long-Yau Lin, Jiunn-Liang Ko, Po-Hui Wang   +4 more
doaj   +1 more source