Results 41 to 50 of about 6,648 (299)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

ENZYMATIC-SYNTHESIS OF UNIFORMLY P-32-LABELED POLYRIBONUCLEOTIDES AND HIGH-SPECIFIC-ACTIVITY RIBONUCLEOSIDE 5'-[ALPHA-P-32]DIPHOSPHATES

, 1985
Uniformly 32P-labeled polyribonucleotides of high specific activity can be rapidly and easily synthesized from commercially available ribonucleoside 5-[alpha-32P]triphosphates by using two enzymes in sequence.
Kang, Changwon, Cantor, CR
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Potent Anti‐HIV Activity of Alkyl‐Modified DiPPro‐Nucleotides

Small Structures
Two convergent approaches for synthesizing a new class of nucleoside diphosphate prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides comprise an acyloxybenzyl group in combination with a lipophilic alkyl residue at ...
Xiao Jia, Dominique Schols, Chris Meier
doaj   +1 more source

Triclinic–Cubic Phase Transition and Negative Expansion in the Actinide IV (Th, U, Np, Pu) Diphosphates

, 2016
The AnP2O7 diphosphates (An = Th, U, Np, Pu) have been synthesized by various routes depending on the stability of the AnIV cation and its suitability for the unusual octahedral environment.
Gilles Wallez (1355916), Nicolas Clavier (1565191), Rudy J. M. Konings (1355904), Philippe E. Raison (1355925), Laurent Delevoye (1475662), Karin Popa (2098396), Andrew N. Fitch (1810882), Nicolas Dacheux (1565194), Denis Bykov (2098399), Damien Bregiroux (2098393)   +9 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Golgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulence. [PDF]

PLoS Neglected Tropical Diseases, 2014
Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate diphosphohydrolases (NTPDases) which hydrolyze a broad range of nucleoside tri- and diphosphates.
Fiona M Sansom, Julie E Ralton, M Fleur Sernee, Alice M Cohen, David J Hooker, Elizabeth L Hartland, Thomas Naderer, Malcolm J McConville   +7 more
doaj   +1 more source

An integrated approach to evaluate acetamiprid-induced oxidative damage to tRNA in human cells based on oxidized nucleotide and tRNA profiling

Environment International, 2023
Acetamiprid is poisonous to mammals due to severe acetamiprid-induced oxidative stress that could cause mitochondrial dysfunctions, lipid and protein oxidation, inflammation, apoptosis, and DNA damage.
Hui-Xia Zhang, Dian Yu, Jian-Feng Sun, Ling Zeng, Cai-Yun Wang, Li-Ping Bai, Guo-Yuan Zhu, Zhi-Hong Jiang, Wei Zhang   +8 more
doaj   +1 more source

Données cristallographiques sur deux diphosphates mixtes de cadmium˗potassium : Cd K2P2O7 et Cd K2P2O7 • 4H2O

, 1972
Averbuch Marie-Thérèse. Données cristallographiques sur deux diphosphates mixtes de cadmium˗potassium : Cd K2P2O7 et Cd K2P2O7 • 4H2O. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 95, 4, 1972. pp.
Averbuch-Pouchot, Marie-Thérèse, Marie-Thérèse Averbuch   +1 more
core   +1 more source