Results 31 to 40 of about 7,026 (202)

Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa

Communications Chemistry, 2023
The large superfamily of labdane-related diterpenoids is defined by the cyclization of linear geranylgeranyl pyrophosphate (GGPP), catalyzed by copalyl diphosphate synthases (CPSs) to form the basic decalin core, the copalyl diphosphates (CPPs).
Xiaoli Ma, Haifeng Xu, Yuru Tong, Yunfeng Luo, Qinghua Dong, Tao Jiang   +5 more
doaj   +1 more source

Nucleoside Diphosphate Prodrugs [PDF]

Nucleic Acids Symposium Series, 2008
Nucleoside analogs are widely applied in antiviral and antitumor therapy. A severe limitation of these compounds arises from the need of biotransformation to the eventually active nucleoside triphosphates by stepwise addition of phosphate by kinases. This problem can be circumvented by employing reversibly masked nucleotides (prodrugs).
Meier, Chris, Jessen, Henning, Balzarini, Jan   +2 more
openaire   +3 more sources

Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids

Beilstein Journal of Organic Chemistry, 2019
8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly ...
Melodi Demiray, David J. Miller, Rudolf K. Allemann   +2 more
doaj   +1 more source

Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. [PDF]

PLoS Biology, 2014
Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport ...
Hua Huang, Elena J Levin, Shian Liu, Yonghong Bai, Steve W Lockless, Ming Zhou   +5 more
doaj   +1 more source

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

Nature Communications, 2019
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are ...
Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran, Xingming Deng   +12 more
doaj   +1 more source

1-β-d-Arabinofuranosylcytosine-5′-alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C

Journal of Lipid Research, 1998
ara-Cytidine-5′-alkylphosphonophosphates and the corresponding -diphosphates were found to be cytostatically active in vitro against the human mammary epithelial cell line H184 A1N4 and the human mammary tumor cell line MaTu.
H. Brachwitz, J. Bergmann, I. Fichtner, Y. Thomas, C. Vollgraf, P. Langen, W.E. Berdel   +6 more
doaj   +1 more source

Formation of Diphosphates. A NMR Study on the Mechanism and Stereochemistry of Diphosphate Formation from Chiral Dioxaphosphorinanes

, 2016
During the use of chiral 2-oxo-1,3,2-dioxaphosphorinanes as derivatizing reagents in the enantiomeric excess determination of amines, alcohols, and unprotected amino acids, minor traces of side reaction products were observed by 1H and 31P NMR ...
Ben L. Feringa (1429174), Huub Kooijman (2370253), Ron Hulst (2648005), Robert W. J. Zijlstra (2674444), Anthony L. Spek (1913542), Wilberth Smeets (3008220), Johanna M. Visser (3008217)   +6 more
core   +2 more sources

Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status.

PLoS ONE, 2015
BackgroundRibonucleotide reductase catalyzes the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. The functional enzyme consists of two subunits - one large (RRM1) and one small (RRM2 or RRM2b) subunit.
Vei Mah, Mohammad Alavi, Diana C Márquez-Garbán, Erin L Maresh, Sara R Kim, Steve Horvath, Lora Bagryanova, Sara Huerta-Yepez, David Chia, Richard Pietras, Lee Goodglick   +10 more
doaj   +1 more source

NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity [PDF]

, 2009
The human NUDT5 protein catalyzes the hydrolysis of 8-hydroxy-dGDP. To examine its substrate specificity, four oxidized deoxyribonucleotides (2-hydroxy-dADP, 8-hydroxy-dADP, 5-formyl-dUDP, and 5-hydroxy-dCDP) were incubated with the NUDT5 protein ...
Hori, Mika, Harashima, Hideyoshi, Arimori, Takao, Yamagata, Yuriko, Kamiya, Hiroyuki, Sekiguchi, Mutsuo   +5 more
core   +1 more source

Interactions between the transmembrane domains of CD39: identification of interacting residues by yeast selection.

ScienceOpen Research, 2014
Rat CD39, a membrane-bound ectonucleoside triphosphate diphosphohydrolase that hydrolyzes extracellular nucleoside tri- and diphosphates, is anchored to the membrane by two transmembrane domains at the two ends of the molecule.
Guido Guidotti, Sari Paavilainen
doaj   +1 more source