Results 31 to 40 of about 6,648 (299)
NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity [PDF]
, 2009 The human NUDT5 protein catalyzes the hydrolysis of 8-hydroxy-dGDP. To examine its substrate specificity, four oxidized deoxyribonucleotides (2-hydroxy-dADP, 8-hydroxy-dADP, 5-formyl-dUDP, and 5-hydroxy-dCDP) were incubated with the NUDT5 protein ...
Hori, Mika +5 more
core +1 more source
ScienceOpen Research, 2014 Rat CD39, a membrane-bound ectonucleoside triphosphate diphosphohydrolase that hydrolyzes extracellular nucleoside tri- and diphosphates, is anchored to the membrane by two transmembrane domains at the two ends of the molecule.
Guido Guidotti, Sari Paavilainen
doaj +1 more source
Plants, 2020 Terpene synthases make up a large family of enzymes that convert prenyl diphosphates into an enormous variety of terpene skeletons. Due to their electrophilic reaction mechanism—which involves the formation of carbocations followed by hydride shifts and ...
Tobias G. Köllner +2 more
doaj +1 more source
Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication. [PDF]
PLoS Computational Biology, 2011 Using a computational model, we simulated mitochondrial deoxynucleotide metabolism and mitochondrial DNA replication. Our results indicate that the output from the mitochondrial salvage enzymes alone is inadequate to support a mitochondrial DNA ...
Vishal V Gandhi, David C Samuels
doaj +1 more source
Efficient One-Step Syntheses of Isoprenoid Conjugates of Nucleoside 5‘-Diphosphates
, 2016 Isoprenoid conjugates of nucleoside 5‘-diphosphates were efficiently synthesized by one-step nucleophilic displacement reactions of either isoprenyl chlorides or isopentenyl tosylate with nucleoside 5 ...
A. Ian Scott (2533291) +1 more
core +1 more source
Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis
Beilstein Journal of Organic Chemistry, 2019 Aromatic prenyltransferases (PTases) are enzymes that catalyze Friedel–Crafts reactions between aromatic compounds and isoprenoid diphosphates. In hapalindole biosynthesis, the aromatic PTases AmbP1 and AmbP3 exhibit surprisingly plastic selectivities ...
Takayoshi Awakawa, Ikuro Abe
doaj +1 more source
Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A
Redox Biology, 2021 The metastasis suppressor protein NME1 is an evolutionarily conserved and multifunctional enzyme that plays an important role in suppressing the invasion and metastasis of tumour cells.
Bess Yi Kun Yu +12 more
doaj +1 more source
, 2012 International audienceThe AnP2O7 diphosphates (An = Th, U, Np, Pu) have been synthesized by various routes depending on the stability of the AnIV cation and its suitability for the unusual octahedral environment.
Dacheux, Nicolas +9 more
core +2 more sources
Transcriptome analysis of bitter acid biosynthesis and precursor pathways in hop (
BMC Plant Biology, 2013 Background Bitter acids (e.g. humulone) are prenylated polyketides synthesized in lupulin glands of the hop plant (Humulus lupulus) which are important contributors to the bitter flavour and stability of beer.
Clark Shawn M +4 more
doaj +1 more source
Emulsifiers in ultra-processed foods in the UK food supply
Public Health Nutrition, 2023 Objective: Ultra-processed foods (UPF), including those containing food additive emulsifiers, have received research attention due to evidence implicating them in the pathogenesis of certain diseases.
Alicia Sandall +3 more
doaj +1 more source