Results 31 to 40 of about 5,801 (161)

Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A

Redox Biology, 2021
The metastasis suppressor protein NME1 is an evolutionarily conserved and multifunctional enzyme that plays an important role in suppressing the invasion and metastasis of tumour cells.
Bess Yi Kun Yu, Maria-Armineh Tossounian, Stefan Denchev Hristov, Ryan Lawrence, Pallavi Arora, Yugo Tsuchiya, Sew Yeu Peak-Chew, Valeriy Filonenko, Sally Oxenford, Richard Angell, Jerome Gouge, Mark Skehel, Ivan Gout   +12 more
doaj   +1 more source

Emulsifiers in ultra-processed foods in the UK food supply

Public Health Nutrition, 2023
Objective: Ultra-processed foods (UPF), including those containing food additive emulsifiers, have received research attention due to evidence implicating them in the pathogenesis of certain diseases.
Alicia Sandall, Leanne Smith, Erika Svensen, Kevin Whelan   +3 more
doaj   +1 more source

Transcriptome analysis of bitter acid biosynthesis and precursor pathways in hop (Humulus lupulus)

BMC Plant Biology, 2013
Background Bitter acids (e.g. humulone) are prenylated polyketides synthesized in lupulin glands of the hop plant (Humulus lupulus) which are important contributors to the bitter flavour and stability of beer.
Clark Shawn M, Vaitheeswaran Vinidhra, Ambrose Stephen J, Purves Randy W, Page Jonathan E   +4 more
doaj   +1 more source

Potent Anti‐HIV Activity of Alkyl‐Modified DiPPro‐Nucleotides

Small Structures
Two convergent approaches for synthesizing a new class of nucleoside diphosphate prodrugs bearing different nucleoside analogs are reported herein. The DiPPro‐nucleotides comprise an acyloxybenzyl group in combination with a lipophilic alkyl residue at ...
Xiao Jia, Dominique Schols, Chris Meier
doaj   +1 more source

Golgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulence. [PDF]

PLoS Neglected Tropical Diseases, 2014
Parasitic protozoa, such as Leishmania species, are thought to express a number of surface and secreted nucleoside triphosphate diphosphohydrolases (NTPDases) which hydrolyze a broad range of nucleoside tri- and diphosphates.
Fiona M Sansom, Julie E Ralton, M Fleur Sernee, Alice M Cohen, David J Hooker, Elizabeth L Hartland, Thomas Naderer, Malcolm J McConville   +7 more
doaj   +1 more source

An integrated approach to evaluate acetamiprid-induced oxidative damage to tRNA in human cells based on oxidized nucleotide and tRNA profiling

Environment International, 2023
Acetamiprid is poisonous to mammals due to severe acetamiprid-induced oxidative stress that could cause mitochondrial dysfunctions, lipid and protein oxidation, inflammation, apoptosis, and DNA damage.
Hui-Xia Zhang, Dian Yu, Jian-Feng Sun, Ling Zeng, Cai-Yun Wang, Li-Ping Bai, Guo-Yuan Zhu, Zhi-Hong Jiang, Wei Zhang   +8 more
doaj   +1 more source

Comparative analysis and validation of the malachite green assay for the high throughput biochemical characterization of terpene synthases

MethodsX, 2014
Terpenes are the largest group of natural products with important and diverse biological roles, while of tremendous economic value as fragrances, flavours and pharmaceutical agents.
Maria Vardakou, Melissa Salmon, Juan A. Faraldos, Paul E. O’Maille   +3 more
doaj   +1 more source

Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria

Current Research in Structural Biology
Class I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism.
Lumbini R. Yadav, Vasudha Sharma, Maheswaran Shanmugam, Shekhar C. Mande   +3 more
doaj   +1 more source

Guanosine 5‘-diphosphate-3‘-diphosphate inhibition of adenylosuccinate synthetase.

Journal of Biological Chemistry, 1979
The mechanism of ppGpp inhibition of adenylosuccinate synthetase (EC 6.3.4.4) was examined. Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP. This is in contrast to an earlier report (Gallant, J., Irr, J., and Cashel, M. (1971) J. Biol. Chem.
M M, Stayton, H J, Fromm
openaire   +2 more sources

Demonstration of an oligosaccharide-diphosphodolichol diphosphatase activity whose subcellular localization is different than those of dolichyl-phosphate-dependent enzymes of the dolichol cycle

Journal of Lipid Research, 2016
Oligosaccharyl phosphates (OSPs) are hydrolyzed from oligosaccharide-diphosphodolichol (DLO) during protein N-glycosylation by an uncharacterized process.
Ahmad Massarweh, Michaël Bosco, Soria Iatmanen-Harbi, Clarice Tessier, Nicolas Auberger, Patricia Busca, Isabelle Chantret, Christine Gravier-Pelletier, Stuart E.H. Moore   +8 more
doaj   +1 more source