Results 11 to 20 of about 6,648 (299)

A procedure for the preparation and isolation of nucleoside-5’-diphosphates

Beilstein Journal of Organic Chemistry, 2015
Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5’-tosylnucleosides to afford nucleoside-5’-diphosphates. Selective precipitation permitted the direct isolation of
Heidi J. Korhonen, Hannah L. Bolt, David R. W. Hodgson   +2 more
doaj   +3 more sources

A Trichome-Specific, Plastid-Localized Tanacetum cinerariifolium Nudix Protein Hydrolyzes the Natural Pyrethrin Pesticide Biosynthetic Intermediate trans-Chrysanthemyl Diphosphate

Frontiers in Plant Science, 2020
Tanacetum cinerariifolium flowers synthesize six pyrethrins that function as effective insecticides. trans-Chrysanthemol is an early intermediate in the synthesis of the monoterpene moiety of pyrethrins.
Wei Li, Wei Li, Daniel B. Lybrand, Haiyang Xu, Haiyang Xu, Fei Zhou, Robert L. Last, Robert L. Last, Eran Pichersky   +8 more
doaj   +1 more source

Engineered geranyl diphosphate methyltransferase produces 2-methyl-dimethylallyl diphosphate as a noncanonical C6 unit for terpenoid biosynthesis

Synthetic and Systems Biotechnology, 2023
Terpenoids constitute the largest class of natural products with complex structures, essential functions, and versatile applications. Creation of new building blocks beyond the conventional five-carbon (C5) units, dimethylallyl diphosphate (DMAPP) and ...
Chen-Yang Xia, Bo-Wen Lu, Ji-Yun Cui, Bai-Yang Wang, Yue-Yang Sun, Fei Gan   +5 more
doaj   +1 more source

Isopentenyl Diphosphate Isomerase. Mechanism-Based Inhibition by Diene Analogues of Isopentenyl Diphosphate and Dimethylallyl Diphosphate [PDF]

Journal of the American Chemical Society, 2005
Isopentenyl diphosphate isomerase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This is an essential step in the mevalonate entry into the isoprenoid biosynthetic pathway. The isomerization catalyzed by type I IDI involves protonation of the carbon-carbon double bond in IPP or DMAPP to form ...
Wu, Zheng, Wouters, Johan, Poulter, C. Dale   +2 more
openaire   +3 more sources

Formation of Diphosphates. A NMR Study on the Mechanism and Stereochemistry of Diphosphate Formation from Chiral Dioxaphosphorinanes [PDF]

, 2000
During the use of chiral 2-oxo-1,3,2-dioxaphosphorinanes as derivatizing reagents in the enantiomeric excess determination of amines, alcohols, and unprotected amino acids, minor traces of side reaction products were observed by 1H and 31P NMR ...
Zijlstra, Robert W.J., de Vries, N. Koen, Visser, Johanna M.,, Spek, Anthony L.,, Feringa, Ben L., Vries, N. Koen de,, Kooijman, Huub,, Smeets, Wilberth,, Smeets, Wilberth, Feringa, Ben L.,, Hulst, Ron,, Hulst, Ron, Zijlstra, Robert W.J.,, Visser, Johanna M., Kooijman, Huub, Spek, Anthony L.   +15 more
core   +3 more sources

Investigation of Pyrophosphates KYP₂O₇Co-Doped with Lanthanide Ions Useful for Theranostics

Nanomaterials, 2019
Diphosphate compounds (KYP2O7) co-doped with Yb3+ and Er3+ ions were obtained by one step urea assisted combustion synthesis. The experimental parameters of synthesis were optimized using an experimental design approach related to co-dopants ...
Adam Watras, Marta Wujczyk, Michael Roecken, Katarzyna Kucharczyk, Krzysztof Marycz, Rafal J. Wiglusz   +5 more
doaj   +1 more source

Lipophilic Nucleoside Triphosphate Prodrugs of Anti‐HIV Active Nucleoside Analogs as Potential Antiviral Compounds

Advanced Science, 2023
Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate prodrugs of different nucleoside analogs is disclosed.
Xiao Jia, Dominique Schols, Chris Meier
doaj   +1 more source

Making Molecules with Clay: Layered Double Hydroxides, Pentopyranose Nucleic Acids and the Origin of Life

Life, 2019
A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions.
Harold S. Bernhardt
doaj   +1 more source

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

mBio, 2022
Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well as longer ...
Melissa A. Sleda, Zhu-Hong Li, Ranjan Behera, Baihetiya Baierna, Catherine Li, Jomkwan Jumpathong, Satish R. Malwal, Makoto Kawamukai, Eric Oldfield, Silvia N. J. Moreno   +9 more
doaj   +1 more source

Transcriptional profile of genes involved in the production of terpenes and glyceollins in response to biotic stresses in soybean [PDF]

Genetics and Molecular Biology, 2020
Terpenes produced by plants comprise a diverse range of secondary metabolites, including volatile organic compounds (VOCs). Terpene VOC production may be altered after damage or by biological stimuli such as bacterial, fungal and insects, and subsequent ...
Talitta Regina Parmezan, Salvador Lima Brito Júnior, Kenia de Carvalho, Moisés de Aquino, Michael Birkett, John Pickett, Estela de Oliveira Nunes, Ricardo Vilela Abdelnor, Clara Beatriz Hoffmann Campo, Francismar Corrêa Marcelino-Guimarães   +9 more
doaj   +1 more source