Results 21 to 30 of about 5,801 (161)

Nucleoside Diphosphate Prodrugs [PDF]

Nucleic Acids Symposium Series, 2008
Nucleoside analogs are widely applied in antiviral and antitumor therapy. A severe limitation of these compounds arises from the need of biotransformation to the eventually active nucleoside triphosphates by stepwise addition of phosphate by kinases. This problem can be circumvented by employing reversibly masked nucleotides (prodrugs).
Meier, Chris, Jessen, Henning, Balzarini, Jan   +2 more
openaire   +3 more sources

Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids

Beilstein Journal of Organic Chemistry, 2019
8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly ...
Melodi Demiray, David J. Miller, Rudolf K. Allemann   +2 more
doaj   +1 more source

Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. [PDF]

PLoS Biology, 2014
Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport ...
Hua Huang, Elena J Levin, Shian Liu, Yonghong Bai, Steve W Lockless, Ming Zhou   +5 more
doaj   +1 more source

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

Nature Communications, 2019
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are ...
Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran, Xingming Deng   +12 more
doaj   +1 more source

1-β-d-Arabinofuranosylcytosine-5′-alkylphosphonophosphates and diphosphates: new orally active derivatives of ara-C

Journal of Lipid Research, 1998
ara-Cytidine-5′-alkylphosphonophosphates and the corresponding -diphosphates were found to be cytostatically active in vitro against the human mammary epithelial cell line H184 A1N4 and the human mammary tumor cell line MaTu.
H. Brachwitz, J. Bergmann, I. Fichtner, Y. Thomas, C. Vollgraf, P. Langen, W.E. Berdel   +6 more
doaj   +1 more source

Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status.

PLoS ONE, 2015
BackgroundRibonucleotide reductase catalyzes the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. The functional enzyme consists of two subunits - one large (RRM1) and one small (RRM2 or RRM2b) subunit.
Vei Mah, Mohammad Alavi, Diana C Márquez-Garbán, Erin L Maresh, Sara R Kim, Steve Horvath, Lora Bagryanova, Sara Huerta-Yepez, David Chia, Richard Pietras, Lee Goodglick   +10 more
doaj   +1 more source

Interactions between the transmembrane domains of CD39: identification of interacting residues by yeast selection.

ScienceOpen Research, 2014
Rat CD39, a membrane-bound ectonucleoside triphosphate diphosphohydrolase that hydrolyzes extracellular nucleoside tri- and diphosphates, is anchored to the membrane by two transmembrane domains at the two ends of the molecule.
Guido Guidotti, Sari Paavilainen
doaj   +1 more source

Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication. [PDF]

PLoS Computational Biology, 2011
Using a computational model, we simulated mitochondrial deoxynucleotide metabolism and mitochondrial DNA replication. Our results indicate that the output from the mitochondrial salvage enzymes alone is inadequate to support a mitochondrial DNA ...
Vishal V Gandhi, David C Samuels
doaj   +1 more source

The Product Specificities of Maize Terpene Synthases TPS4 and TPS10 Are Determined Both by Active Site Amino Acids and Residues Adjacent to the Active Site

Plants, 2020
Terpene synthases make up a large family of enzymes that convert prenyl diphosphates into an enormous variety of terpene skeletons. Due to their electrophilic reaction mechanism—which involves the formation of carbocations followed by hydride shifts and ...
Tobias G. Köllner, Jörg Degenhardt, Jonathan Gershenzon   +2 more
doaj   +1 more source

Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis

Beilstein Journal of Organic Chemistry, 2019
Aromatic prenyltransferases (PTases) are enzymes that catalyze Friedel–Crafts reactions between aromatic compounds and isoprenoid diphosphates. In hapalindole biosynthesis, the aromatic PTases AmbP1 and AmbP3 exhibit surprisingly plastic selectivities ...
Takayoshi Awakawa, Ikuro Abe
doaj   +1 more source