Results 21 to 30 of about 6,648 (299)
Nucleoside Diphosphate Prodrugs [PDF]
Nucleic Acids Symposium Series, 2008 Nucleoside analogs are widely applied in antiviral and antitumor therapy. A severe limitation of these compounds arises from the need of biotransformation to the eventually active nucleoside triphosphates by stepwise addition of phosphate by kinases. This problem can be circumvented by employing reversibly masked nucleotides (prodrugs).
Meier, Chris +2 more
openaire +3 more sources
A Novel Method for the Preparation of Nucleoside Diphosphates
, 2016 Sugar nucleoside diphosphates have been prepared using an efficient phosphate coupling reaction that employs a highly reactive zwitterionic phosphoramidate intermediate as the phosphorylating ...
Caren L. Freel Meyers (2026792) +1 more
core +2 more sources
Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa
Communications Chemistry, 2023 The large superfamily of labdane-related diterpenoids is defined by the cyclization of linear geranylgeranyl pyrophosphate (GGPP), catalyzed by copalyl diphosphate synthases (CPSs) to form the basic decalin core, the copalyl diphosphates (CPPs).
Xiaoli Ma +5 more
doaj +1 more source
Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids
Beilstein Journal of Organic Chemistry, 2019 8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly ...
Melodi Demiray +2 more
doaj +1 more source
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. [PDF]
PLoS Biology, 2014 Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport ...
Hua Huang +5 more
doaj +1 more source
Acetylation regulates ribonucleotide reductase activity and cancer cell growth
Nature Communications, 2019 Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are ...
Guo Chen +12 more
doaj +1 more source
Journal of Lipid Research, 1998 ara-Cytidine-5′-alkylphosphonophosphates and the corresponding -diphosphates were found to be cytostatically active in vitro against the human mammary epithelial cell line H184 A1N4 and the human mammary tumor cell line MaTu.
H. Brachwitz +6 more
doaj +1 more source
, 2020 Three thallium(I) diphosphates with compositions Tl4P2O7, Tl2H2P2O7, Tl2H2P2O7(H2O)0.5 and the mixed-valent thallium(I,III) diphosphate Tl2P2O7 (= TlITlIIIP2O7) were obtained from aqueous solutions using an ion-exchange resin (Tl4P2O7), through thermal ...
Weil, Matthias; orcid: +1 more
core +1 more source
, 2016 During the use of chiral 2-oxo-1,3,2-dioxaphosphorinanes as derivatizing reagents in the enantiomeric excess determination of amines, alcohols, and unprotected amino acids, minor traces of side reaction products were observed by 1H and 31P NMR ...
Ben L. Feringa (1429174) +6 more
core +2 more sources
PLoS ONE, 2015 BackgroundRibonucleotide reductase catalyzes the conversion of ribonucleotide diphosphates to deoxyribonucleotide diphosphates. The functional enzyme consists of two subunits - one large (RRM1) and one small (RRM2 or RRM2b) subunit.
Vei Mah +10 more
doaj +1 more source