Results 21 to 30 of about 7,026 (202)

Potentiating Vγ9Vδ2 T cell proliferation and assessing their cytotoxicity towards adherent cancer cells at the single cell level

open access: yesBiology Open, 2022
Vγ9Vδ2 T cells is the dominant γδ T cell subset in human blood. They are cytotoxic and activated by phosphoantigens whose concentrations are increased in cancer cells, making the cancer cells targets for Vγ9Vδ2 T cell immunotherapy.
Chenxiao Liu   +3 more
doaj   +1 more source

A Trichome-Specific, Plastid-Localized Tanacetum cinerariifolium Nudix Protein Hydrolyzes the Natural Pyrethrin Pesticide Biosynthetic Intermediate trans-Chrysanthemyl Diphosphate

open access: yesFrontiers in Plant Science, 2020
Tanacetum cinerariifolium flowers synthesize six pyrethrins that function as effective insecticides. trans-Chrysanthemol is an early intermediate in the synthesis of the monoterpene moiety of pyrethrins.
Wei Li   +8 more
doaj   +1 more source

Engineered geranyl diphosphate methyltransferase produces 2-methyl-dimethylallyl diphosphate as a noncanonical C6 unit for terpenoid biosynthesis

open access: yesSynthetic and Systems Biotechnology, 2023
Terpenoids constitute the largest class of natural products with complex structures, essential functions, and versatile applications. Creation of new building blocks beyond the conventional five-carbon (C5) units, dimethylallyl diphosphate (DMAPP) and ...
Chen-Yang Xia   +5 more
doaj   +1 more source

Isopentenyl Diphosphate Isomerase. Mechanism-Based Inhibition by Diene Analogues of Isopentenyl Diphosphate and Dimethylallyl Diphosphate [PDF]

open access: yesJournal of the American Chemical Society, 2005
Isopentenyl diphosphate isomerase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This is an essential step in the mevalonate entry into the isoprenoid biosynthetic pathway. The isomerization catalyzed by type I IDI involves protonation of the carbon-carbon double bond in IPP or DMAPP to form ...
Wu, Zheng   +2 more
openaire   +3 more sources

Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics

open access: yesNanomaterials, 2019
Diphosphate compounds (KYP2O7) co-doped with Yb3+ and Er3+ ions were obtained by one step urea assisted combustion synthesis. The experimental parameters of synthesis were optimized using an experimental design approach related to co-dopants ...
Adam Watras   +5 more
doaj   +1 more source

Lipophilic Nucleoside Triphosphate Prodrugs of Anti‐HIV Active Nucleoside Analogs as Potential Antiviral Compounds

open access: yesAdvanced Science, 2023
Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate prodrugs of different nucleoside analogs is disclosed.
Xiao Jia, Dominique Schols, Chris Meier
doaj   +1 more source

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

open access: yesmBio, 2022
Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well as longer ...
Melissa A. Sleda   +9 more
doaj   +1 more source

Transcriptional profile of genes involved in the production of terpenes and glyceollins in response to biotic stresses in soybean [PDF]

open access: yesGenetics and Molecular Biology, 2020
Terpenes produced by plants comprise a diverse range of secondary metabolites, including volatile organic compounds (VOCs). Terpene VOC production may be altered after damage or by biological stimuli such as bacterial, fungal and insects, and subsequent ...
Talitta Regina Parmezan   +9 more
doaj   +1 more source

A Novel Method for the Preparation of Nucleoside Diphosphates

open access: yes, 2016
Sugar nucleoside diphosphates have been prepared using an efficient phosphate coupling reaction that employs a highly reactive zwitterionic phosphoramidate intermediate as the phosphorylating ...
Caren L. Freel Meyers (2026792)   +1 more
core   +2 more sources

Formation of diphosphates. A NMR study on the mechanism and stereochemistry of diphosphate formation from chiral dioxaphosphorinanes [PDF]

open access: yes, 2000
During the use of chiral 2-oxo-1,3,2-dioxaphosphorinanes as derivatizing reagents in the enantiomeric excess determination of amines, alcohols, and unprotected amino acids, minor traces of side reaction products were observed by 1 H and 31 P NMR ...
Feringa, B.L.   +23 more
core   +1 more source

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