Results 71 to 80 of about 7,026 (202)

Rational development of nucleoside diphosphate prodrugs: DiPPro-compounds

, 2015
The bio-reversible protection of nucleoside diphosphates is summarized. The design, the hydrolysis behavior, and the antiviral activity of these prodrugs of NDPs are described.
Meier, C., Weinschenk, L., Schulz, T., Pertenbreiter, F., Meier, Chris, Jessen, Henning, Balzarini, Jan, Jessen, H.J.   +7 more
core   +1 more source

Biological functions and clinical implications of the CMPK2 across multisystemic diseases

Cell & Bioscience
Cytidine/Uridine monophosphate kinase 2 (CMPK2) is a crucial enzyme responsible for the phosphorylation of nucleotides, specifically converting cytidine monophosphate (CMP) and uridine monophosphate (UMP) into their respective diphosphates, known as ...
Jia Li, Qing Liu, Jie Yang, Ziyi Yang, Mingxin Zhang, Jie Zhang, Chao Sun   +6 more
doaj   +1 more source

Interference of Nucleoside Diphosphates and Inorganic Phosphate with Nucleoside‐Triphosphate‐Dependent Calcium Fluxes and Calcium‐Dependent Nucleoside‐Triphosphate Hydrolysis in Membranes of Sarcoplasmic‐Reticulum Vesicles

, 1981
Calcium fluxes across the membranes of the sarcoplasmic reticulum vesicles supported by ATP and by GTP were analyzed with respect to the effects of the reaction products nucleoside diphosphate, Pi and intravesicular calcium. Calcium fluxes and hydrolysis
Waas, W., Hasselbach, W.
core   +1 more source

Bis(benzoyloxybenzyl)-DiPPro Nucleoside Diphosphates of Anti-HIV Active Nucleoside Analogues

, 2015
Nucleoside analogues are extensively used as antiviral and anticancer agents. Their efficiency is dependent on their metabolism into the ultimately active nucleoside triphosphates.
Schols, Dominique, Weinschenk, Lina, Meier, Chris, Gollnest, Tristan, Balzarini, Jan   +4 more
core   +1 more source

Chemistry of a-aminonitriles. Aldomerization of glycolaldehyde phosphate to rac-hexose 2,4,6-triphosphates and (in presence of formaldehyde) rac-pentose 2,4-diphosphates: rac-allose 2,4,6-triphosphate and rac-ribose 2,4-diphosphate are the main reaction products

, 2004
Glycoaldehyde phosphate aldomerizes in aq. NaOH to a product mixt. contg. the racemates of two diastereomeric tetrose 2,4-diphosphates and 8 hexose 2,4,5-triphosphates.
Mueller, Daniel, Pitsch, Stefan, Kittaka, Atsushi, Eschenmoser, Albert, Wagner, Ernst, Wintner, Claude E.   +5 more
core   +2 more sources

Functional mechanistic diversity of the NUDIX effectors in fungal pathogens

Phytopathology Research
NUcleoside Diphosphate-linked to moiety X (NUDIX) hydrolases are ubiquitous enzymes that maintain metabolic homeostasis by hydrolyzing potentially toxic nucleoside diphosphates.
Vijai Bhadauria, Guangjun Li
doaj   +1 more source

Optical detection of di- and triphosphate anions with mixed monolayer-protected gold nanoparticles containing zinc(II)–dipicolylamine complexes

Beilstein Journal of Organic Chemistry, 2020
Gold nanoparticles covered with a mixture of ligands of which one type contains solubilizing triethylene glycol residues and the other peripheral zinc(II)–dipicolylamine (DPA) complexes allowed the optical detection of hydrogenphosphate, diphosphate, and
Lena Reinke, Julia Bartl, Marcus Koch, Stefan Kubik   +3 more
doaj   +1 more source

New biocatalysts for one pot multistep enzymatic synthesis of pyrimidine nucleoside diphosphates from readily available reagents

, 2015
Since the preparation of nucleoside 5′-diphosphates by classical methodologies is complex, multistep enzymatic systems were explored to synthesize pyrimidine nucleoside 5′-diphosphates starting from readily available reagents.
Valino, Ana Laura, Iribarren, Adolfo Marcelo, Lewkowicz, Elizabeth Sandra   +2 more
core   +1 more source

Conformational studies on pyrimidine 5'-monophosphates and 3',5'-diphosphates. Effect of the phosphate groups on the backbone conformation of polynucleotides

, 1973
In continuation of our studies on the effect of the base and the phosphate groups on the glycosyl and the sugar-phosphate backbone conformation, we have carried out semi-empirical potential energy calculations on the common 5'- and 3'5'-ribopyrimidine ...
Sundaralingam, M., Yathindra, N.
core   +1 more source

Electronic structure and atomic structure peculiarities of isomorphic modified zinc diphosphates

, 2014
Effects of partial substitution of Zn by Mn on the electronic and atomic structure of diphosphates Zn₂₋xMnxP₂O₇⋅5H₂O (x = 0.0, 0.7) have been studied out by X-ray photoelectron spectroscopy, IR spectroscopy, NMR and thermogravimetric analysis.
Smolyak, S.S., Karbivskyy, V.L., Kasiyanenko, V.H.   +2 more
core   +1 more source