Isopentenyl Diphosphate Isomerase. Mechanism-Based Inhibition by Diene Analogues of Isopentenyl Diphosphate and Dimethylallyl Diphosphate [PDF]
Journal of the American Chemical Society, 2005 Isopentenyl diphosphate isomerase (IDI) catalyzes the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This is an essential step in the mevalonate entry into the isoprenoid biosynthetic pathway. The isomerization catalyzed by type I IDI involves protonation of the carbon-carbon double bond in IPP or DMAPP to form ...
Wu, Zheng +2 more
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A procedure for the preparation and isolation of nucleoside-5’-diphosphates
Beilstein Journal of Organic Chemistry, 2015 Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5’-tosylnucleosides to afford nucleoside-5’-diphosphates. Selective precipitation permitted the direct isolation of
Heidi J. Korhonen +2 more
doaj +1 more source
Isolation and characterization of Pisum sativum apyrases, PsNTP9 and PsNTP9-DM, cloned and expressed in Escherichia coli [PDF]
, 2019 Adenosine triphosphate (ATP) is widely known as a fuel source for many biochemical processes, and to a lesser degree also as a signaling molecule in plants and animals.
Wallen, Michael Andrew, Jr
core +1 more source
Structural and functional investigations of syn-copalyl diphosphate synthase from Oryza sativa
Communications Chemistry, 2023 The large superfamily of labdane-related diterpenoids is defined by the cyclization of linear geranylgeranyl pyrophosphate (GGPP), catalyzed by copalyl diphosphate synthases (CPSs) to form the basic decalin core, the copalyl diphosphates (CPPs).
Xiaoli Ma +5 more
doaj +1 more source
Spectroscopic and theoretical approaches for studying radical reactions in class I ribonucleotide reductase [PDF]
, 2005 Ribonucleotide reductases (RNRs) catalyze the production of deoxyribonucleotides, which are essential for DNA synthesis and repair in all organisms.
Atkin +17 more
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Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids
Beilstein Journal of Organic Chemistry, 2019 8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly ...
Melodi Demiray +2 more
doaj +1 more source
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. [PDF]
PLoS Biology, 2014 Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport ...
Hua Huang +5 more
doaj +1 more source
Acetylation regulates ribonucleotide reductase activity and cancer cell growth
Nature Communications, 2019 Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are ...
Guo Chen +12 more
doaj +1 more source
Journal of Lipid Research, 1998 ara-Cytidine-5′-alkylphosphonophosphates and the corresponding -diphosphates were found to be cytostatically active in vitro against the human mammary epithelial cell line H184 A1N4 and the human mammary tumor cell line MaTu.
H. Brachwitz +6 more
doaj +1 more source
Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues [PDF]
, 2008 RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents ...
Barr, Eric W. +11 more
core +4 more sources