Challenges of Diphtheria Toxin Detection [PDF]
ToxinsDiphtheria toxin (DT) is the main virulence factor of Corynebacterium diphtheriae, C. ulcerans and C. pseudotuberculosis. Moreover, new Corynebacterium species with the potential to produce diphtheria toxin have also been described.
Marta Prygiel +6 more
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New Corynebacterium Species with the Potential to Produce Diphtheria Toxin [PDF]
Pathogens, 2022 Only three Corynebacterium species are known to produce a lethal exotoxin called diphtheria toxin. These are C. diphtheriae, C. ulcerans and C. pseudotuberculosis.
Marta Prygiel +5 more
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Mutation and Diversity of Diphtheria Toxin in Corynebacterium ulcerans [PDF]
Emerging Infectious Diseases, 2019 Corynebacterium ulcerans infection is emerging in humans. We conducted phylogenetic analyses of C. ulcerans and C. diptheriae, which revealed diverse diphtheria toxin in C. ulcerans.
Ken Otsuji +3 more
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Production of IgY polyclonal antibody against diphtheria toxin and evaluation of its neutralization effect by Vero cell assay [PDF]
BMC Biotechnology, 2021 Background Diphtheria is a bacterial disease which is caused by Corynebacterium diphtheriae. The symptoms are due to the diphtheria toxin produced by the bacteria.
Morteza Rezaeifard +4 more
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Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain [PDF]
Toxins, 2020 Diphtheria toxin, an exotoxin secreted by Corynebacterium that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes,
Mykola V. Rodnin +5 more
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Repurposing FDA-approved disulfiram for targeted inhibition of diphtheria toxin and the binary protein toxins of Clostridium botulinum and Bacillus anthracis [PDF]
Frontiers in PharmacologyMany bacteria act pathogenic by the release of AB-type protein toxins that efficiently enter human or animal cells and act as enzymes in their cytosol.
Joscha Borho +3 more
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BIOLOGICAL PROPERTIES AND MEDICAL APPLICATION OF DIPHTHERIA TOXIN DERIVATIVES [PDF]
Biotechnologia Acta, 2018 The aim of the review was to analyze the literature data related to the application of a variety of diphtheria toxin derivatives. Although studies of the diphtheria toxin interaction with sensitive and resistant mammalian cells have been held for a ...
Manoilov K.Y.
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IMMUNOBIOLOGY OF DIPHTHERIA. RECENT APPROACHES FOR THE PREVENTION, DIAGNOSIS, AND TREATMENT OF DISEASE [PDF]
Biotechnologia Acta, 2013 Diphtheria is a highly contagious life-threatening disease caused by the toxi genic strains of Corynebacterium diphtheria, which are transformed by a bacteriophage carrying the toxin gene.
D. V. Kolybo +6 more
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Assay of Diphtheria Vaccine Potency by Intradermal Challenge Test
Эпидемиология и вакцинопрофилактика, 2023 Relevance. Modern identifying potency (immunogenicity) of diphtheria toxoid tests are based on determining immunized animals resistance for administration challenge toxin or evaluation of protective antibodies level in serum.
E. I. Komarovskaya, О. V. Perelygyna
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INTERACTION OF RECOMBINANT DIPHTHERIA TOXOIDS WITH CELLULAR RECEPTORS in vitro [PDF]
Biotechnologia Acta, 2016 The aim of the research was to compare in vitro characteristics of reception of the natural diphtheria toxin — DT and its nontoxic recombinant analogs — toxoids.
K. Yu. Manoilov +4 more
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