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New Corynebacterium Species with the Potential to Produce Diphtheria Toxin [PDF]
Pathogens, 2022 Only three Corynebacterium species are known to produce a lethal exotoxin called diphtheria toxin. These are C. diphtheriae, C. ulcerans and C. pseudotuberculosis.
Marta Prygiel +5 more
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Challenges of Diphtheria Toxin Detection [PDF]
ToxinsDiphtheria toxin (DT) is the main virulence factor of Corynebacterium diphtheriae, C. ulcerans and C. pseudotuberculosis. Moreover, new Corynebacterium species with the potential to produce diphtheria toxin have also been described.
Marta Prygiel +6 more
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Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis. [PDF]
J Exp Med, 2023 This work demonstrates that diphtheria toxin is a potent trigger for the ZAKα-dependent ribotoxic stress response and the NLRP1 inflammasome in human skin cells. ZAKα inhibition is effective at limiting the skin damage caused by diphtheria toxin in vitro.
Robinson KS +13 more
europepmc +2 more sources
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
Nature Communications, 2017 Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using ...
Mafalda M. A. Pereira +10 more
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The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells
Scientific Reports, 2017 Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be ...
Manuel Schuster +16 more
doaj +2 more sources
THE PRODUCTION OF DIPHTHERIA TOXIN [PDF]
Journal of Experimental Medicine, 1896 Toxin of sufficient strength to kill a 400-gramme guinea-pig in three days and a half in a dose of 0·cubic centimetre developed in suitable bouillon, contained in ordinary Erlenmeyer flasks, within a period of twenty-four hours. In such boullon the toxin reached its greatest strength in from four to seven days (0·005 cubic centimetre killing a 500 ...
W H, Park, A W, Williams
openaire +3 more sources
Toxins, 2016 Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from ...
Leonie Schnell +5 more
doaj +2 more sources
Targeted Diphtheria Toxin-Based Therapy: A Review Article. [PDF]
Front Microbiol, 2019 Cancer remains one of the leading causes of death worldwide. Conventional therapeutic strategies usually offer limited specificity, resulting in severe side effects and toxicity to normal tissues.
Shafiee F +2 more
europepmc +2 more sources
Mutation and Diversity of Diphtheria Toxin in Corynebacterium ulcerans [PDF]
Emerging Infectious Diseases, 2019 Corynebacterium ulcerans infection is emerging in humans. We conducted phylogenetic analyses of C. ulcerans and C. diptheriae, which revealed diverse diphtheria toxin in C. ulcerans.
Ken Otsuji +3 more
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Corynebacterium diphtheriae: Diphtheria Toxin, the tox Operon, and Its Regulation by Fe2+ Activation of apo-DtxR. [PDF]
Microbiol Spectr, 2019 Diphtheria is one of the most well studied of all the bacterial infectious diseases. These milestone studies of toxigenic Corynebacterium diphtheriae along with its primary virulence determinant, diphtheria toxin, have established the paradigm for the ...
Parveen S, Bishai WR, Murphy JR.
europepmc +2 more sources