New Corynebacterium Species with the Potential to Produce Diphtheria Toxin [PDF]
Pathogens, 2022 Only three Corynebacterium species are known to produce a lethal exotoxin called diphtheria toxin. These are C. diphtheriae, C. ulcerans and C. pseudotuberculosis.
Marta Prygiel +5 more
doaj +3 more sources
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages [PDF]
Nature Communications, 2017 Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using ...
Mafalda M. A. Pereira +10 more
doaj +3 more sources
Mutation and Diversity of Diphtheria Toxin in Corynebacterium ulcerans [PDF]
Emerging Infectious Diseases, 2019 Corynebacterium ulcerans infection is emerging in humans. We conducted phylogenetic analyses of C. ulcerans and C. diptheriae, which revealed diverse diphtheria toxin in C. ulcerans.
Ken Otsuji +3 more
doaj +3 more sources
The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells [PDF]
Scientific Reports, 2017 Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be ...
Manuel Schuster +16 more
doaj +3 more sources
Challenges of Diphtheria Toxin Detection [PDF]
ToxinsDiphtheria toxin (DT) is the main virulence factor of Corynebacterium diphtheriae, C. ulcerans and C. pseudotuberculosis. Moreover, new Corynebacterium species with the potential to produce diphtheria toxin have also been described.
Marta Prygiel +6 more
doaj +4 more sources
Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis. [PDF]
J Exp Med, 2023 This work demonstrates that diphtheria toxin is a potent trigger for the ZAKα-dependent ribotoxic stress response and the NLRP1 inflammasome in human skin cells. ZAKα inhibition is effective at limiting the skin damage caused by diphtheria toxin in vitro.
Robinson KS +13 more
europepmc +2 more sources
Epitope Mapping of the Diphtheria Toxin and Development of an ELISA-Specific Diagnostic Assay. [PDF]
Vaccines (Basel), 2021 Background: The diphtheria toxoid antigen is a major component in pediatric and booster combination vaccines and is known to raise a protective humoral immune response upon vaccination.
De-Simone SG +5 more
europepmc +2 more sources
Human antibodies neutralizing diphtheria toxin in vitro and in vivo. [PDF]
Sci Rep, 2020 Diphtheria is an infectious disease caused by Corynebacterium diphtheriae. The bacterium primarily infects the throat and upper airways and the produced diphtheria toxin (DT), which binds to the elongation factor 2 and blocks protein synthesis, can ...
Wenzel EV +9 more
europepmc +2 more sources
Toxins, 2016 Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from ...
Leonie Schnell +5 more
doaj +2 more sources
Detection and Characterization of Diphtheria Toxin Gene-Bearing Corynebacterium Species through a New Real-Time PCR Assay. [PDF]
J Clin Microbiol, 2020 Respiratory diphtheria, characterized by a firmly adherent pseudomembrane, is caused by toxin-producing strains of Corynebacterium diphtheriae, with similar illness produced occasionally by toxigenic Corynebacterium ulcerans or, rarely, Corynebacterium ...
Williams MM +11 more
europepmc +2 more sources