Challenges of Diphtheria Toxin Detection [PDF]
ToxinsDiphtheria toxin (DT) is the main virulence factor of Corynebacterium diphtheriae, C. ulcerans and C. pseudotuberculosis. Moreover, new Corynebacterium species with the potential to produce diphtheria toxin have also been described.
Marta Prygiel +6 more
doaj +4 more sources
New Corynebacterium Species with the Potential to Produce Diphtheria Toxin [PDF]
Pathogens, 2022 Only three Corynebacterium species are known to produce a lethal exotoxin called diphtheria toxin. These are C. diphtheriae, C. ulcerans and C. pseudotuberculosis.
Marta Prygiel +5 more
doaj +2 more sources
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages [PDF]
Nature Communications, 2017 Diphtheria toxin selectively kills cells engineered to express the diphtheria toxin receptor (DTR). Here the authors report a PEGylated version of diphtheria toxin that does not enter the brain, allowing for ablation of only peripheral cells when using ...
Mafalda M. A. Pereira +10 more
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Mutation and Diversity of Diphtheria Toxin in Corynebacterium ulcerans [PDF]
Emerging Infectious Diseases, 2019 Corynebacterium ulcerans infection is emerging in humans. We conducted phylogenetic analyses of C. ulcerans and C. diptheriae, which revealed diverse diphtheria toxin in C. ulcerans.
Ken Otsuji +3 more
doaj +2 more sources
The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells [PDF]
Scientific Reports, 2017 Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be ...
Manuel Schuster +16 more
doaj +2 more sources
Production of IgY polyclonal antibody against diphtheria toxin and evaluation of its neutralization effect by Vero cell assay [PDF]
BMC Biotechnology, 2021 Background Diphtheria is a bacterial disease which is caused by Corynebacterium diphtheriae. The symptoms are due to the diphtheria toxin produced by the bacteria.
Morteza Rezaeifard +4 more
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Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain [PDF]
Toxins, 2020 Diphtheria toxin, an exotoxin secreted by Corynebacterium that causes disease in humans by inhibiting protein synthesis, enters the cell via receptor-mediated endocytosis. The subsequent endosomal acidification triggers a series of conformational changes,
Mykola V. Rodnin +5 more
doaj +2 more sources
Repurposing FDA-approved disulfiram for targeted inhibition of diphtheria toxin and the binary protein toxins of Clostridium botulinum and Bacillus anthracis [PDF]
Frontiers in PharmacologyMany bacteria act pathogenic by the release of AB-type protein toxins that efficiently enter human or animal cells and act as enzymes in their cytosol.
Joscha Borho +3 more
doaj +2 more sources
Screening strategy to identify Cas9 variants with higher HDR activity based on diphtheria toxin. [PDF]
J Biomed SciMatsumoto D +6 more
europepmc +2 more sources
The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles. [PDF]
Pharmaceutics, 2022 Voltà-Durán E +6 more
europepmc +3 more sources